Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jeffim N. Kuznetsov"'
Autor:
Michael A. Durante, Daniel A. Rodriguez, Stefan Kurtenbach, Jeffim N. Kuznetsov, Margaret I. Sanchez, Christina L. Decatur, Helen Snyder, Lynn G. Feun, Alan S. Livingstone, J. William Harbour
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Uveal melanoma is highly metastatic and unresponsive to checkpoint immunotherapy. Here, the authors present single-cell transcriptomics of 59,915 cells in 8 primary and 3 metastatic samples, highlighting the diversity of the tumour microenvironment.
Externí odkaz:
https://doaj.org/article/44e8def81b794cf189b9ab19348ac21d
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
The ability to pair the regulation of metabolism and cellular energetics with oncogenes and tumor suppressor genes provides cancer cells with a growth and survival advantage over normal cells. We investigated the mechanism of cell death induced by 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11bc58bb06a7b0721f066cad99407c0
https://doi.org/10.1158/1541-7786.c.6541816
https://doi.org/10.1158/1541-7786.c.6541816
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
PDF file - 114K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad631281931f07e0561b902b3c819f1
https://doi.org/10.1158/1541-7786.22517752
https://doi.org/10.1158/1541-7786.22517752
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
PDF file - 707K, Salubrinal does not protect ALL from apoptosis induced by the inhibitors of N-linked glycosylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a86d1592439a9cc3edad0eb49baa9e
https://doi.org/10.1158/1541-7786.22517761
https://doi.org/10.1158/1541-7786.22517761
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
PDF file - 240K, Effects of D-mannose on ALL cytotoxicity induced by equimolar concentrations of 2-DG and 2-FDG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6068ab1d7f5a70648f9c7776c2e84381
https://doi.org/10.1158/1541-7786.22517755
https://doi.org/10.1158/1541-7786.22517755
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
PDF file - 1.3MB, Dose-response of 2-DG and AIX in CCRF-CEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afac50dd9fcc75f4720ef635a35b93d9
https://doi.org/10.1158/1541-7786.22517758.v1
https://doi.org/10.1158/1541-7786.22517758.v1
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
PDF file - 415K, Inhibition of mTOR with CCI-779 does not protect ALL cells from 2-DG-cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fb21591c4afc8c7f1cd1cd659f8a08
https://doi.org/10.1158/1541-7786.22517767
https://doi.org/10.1158/1541-7786.22517767
Autor:
Julio C. Barredo, Theodore J. Lampidis, Guy J. Leclerc, Gilles M. Leclerc, Jianfeng Du, Jeffim N. Kuznetsov, Joanna DeSalvo
PDF file - 385K, The AMP analogue AICAr does not significantly affect 2-DG-induced cytotoxicity in ALL cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6223cb2427579dd699cbf6bf9ddbd5
https://doi.org/10.1158/1541-7786.22517764
https://doi.org/10.1158/1541-7786.22517764
Autor:
J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
Purpose:The strong association between BAP1 mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on the DNA methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133dc3d6549bc8eb17c38f7345ba1ba8
https://doi.org/10.1158/1078-0432.c.6528020
https://doi.org/10.1158/1078-0432.c.6528020
Autor:
J. William Harbour, Stefan Kurtenbach, Christina L. Decatur, Karam A. Alawa, Louie Z. Cai, Parker L. Bussies, Jeffim N. Kuznetsov, Matthew G. Field
HyperMethvsDecGE_ChrLoc: Chromosomal loci enriched (FDR < 0.05) for hypermethylated/downregulated genes in Class 2 uveal melanomas compared to Class 1 uveal melanomas HypoMethvsIncGE_ChrLoc: Chromosomal loci enriched (FDR < 0.05) for hypomethylated/u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ff9c25d1c0f0f7711ed40f6b2e1878
https://doi.org/10.1158/1078-0432.22471814.v1
https://doi.org/10.1158/1078-0432.22471814.v1