Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Jeffery W. Walker"'
Autor:
David Dweck, Jeffery W. Walker, Jingsheng Liang, Raquel Sancho Solis, Ying Ge, James D. Potter, Zoraida Diaz-Perez, Yingcai Wang, Jose R. Pinto
Publikováno v:
Journal of Biological Chemistry. 287:2156-2167
The R21C substitution in cardiac troponin I (cTnI) is the only identified mutation within its unique N-terminal extension that is associated with hypertrophic cardiomyopathy (HCM) in man. Particularly, this mutation is located in the consensus sequen
Publikováno v:
Protein Science. 20:894-907
5′-AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that is activated when cellular AMP to ATP ratios rise, potentially serving as a key regulator of cellular energetics. Among the known targets of AMPK are catabolic and ana
Autor:
Jeffery W. Walker, Friederike Cuello, Jeffrey Robbins, Alexandra J. Rowland, Metin Avkiran, Sonya C. Bardswell, Jonathan C. Kentish, Mathias Gautel, Sakthivel Sadayappan
Publikováno v:
Journal of Biological Chemistry. 285:5674-5682
Protein kinase D (PKD), a serine/threonine kinase with emerging cardiovascular functions, phosphorylates cardiac troponin I (cTnI) at Ser(22)/Ser(23), reduces myofilament Ca(2+) sensitivity, and accelerates cross-bridge cycle kinetics. Whether PKD re
Publikováno v:
Biochemistry. 48:8161-8170
Cardiac troponin I (cTnI) is the inhibitory subunit of cardiac troponin, a key myofilament regulatory protein complex located on the thin filaments of the contractile apparatus. cTnI is uniquely specific for the heart and is widely used in clinics as
Publikováno v:
Journal of Muscle Research and Cell Motility. 29:203-212
Heterotrimeric cardiac troponin (cTn) is a critical component of the thin filament regulatory complex in cardiac muscle. Two of the three subunits, cTnI and cTnT, are subject to post-translational modifications such as proteolysis and phosphorylation
Publikováno v:
Molecular & Cellular Proteomics. 7:1838-1849
Cardiac troponin I (cTnI), the inhibitory subunit of the thin filament troponin-tropomyosin regulatory complex, is required for heart muscle relaxation during the cardiac cycle. Expressed only in cardiac muscle, cTnI is widely used in the clinic as a
Autor:
Nathan J. Evans, Jeffery W. Walker
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 86:526-535
G protein-coupled receptors (GPCRs), including endothelin receptor A (ETA) and B (ETB), may form dimers or higher-order oligomers that profoundly influence signaling. Here we examined a PDZ finger motif within the C-terminus of ETA and its role in he
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 294:H2391-H2399
Endothelin (ET)-1 regulates the contractility and growth of the heart by binding G protein-coupled receptors of the ET type A receptor (ETA)/ET type B (ETB) receptor family. ETA, the predominant ET-1 receptor subtype in myocardium, is thought to loca
Publikováno v:
Journal of Biological Chemistry. 282:25517-25526
Biological messengers can be "caged" by adding a single photosensitive group that can be photolyzed by a light flash to achieve spatially and temporally precise biochemical control. Here we report that photolysis of a double-caged form of the second
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H1273-H1281
Cardiac troponin I (TnI) knockout mice exhibit a phenotype of sudden death at 17–18 days after birth due to a progressive loss of TnI. The objective of this study was to gain insight into the physiological consequences of TnI depletion and the caus