Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Jeffery S Cox"'
Autor:
Huntly M Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R Johnson, Guillaume R Golovkine, Samantha L Bell, Claire E Dodd, Erik Van Dis, Wandy L Beatty, Shally R Margolis, Teresa Repasy, Isaac Shaker, Angus Y Lee, Russell E Vance, Sarah A Stanley, Robert O Watson, Nevan J Krogan, Daniel A Portnoy, Bennett H Penn, Jeffery S Cox
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011088 (2023)
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta
Externí odkaz:
https://doaj.org/article/bb529b2bbf75461d932dc89cb0aeb02a
Autor:
Erik Van Dis, Douglas M Fox, Huntly M Morrison, Daniel M Fines, Janet Peace Babirye, Lily H McCann, Sagar Rawal, Jeffery S Cox, Sarah A Stanley
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010721 (2022)
The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ-independent CD4 T cell based control of M. tuberculosis infection
Externí odkaz:
https://doaj.org/article/27b7d1c2b0c840d09a6ae1ce61049d91
Autor:
Jonathan M Budzik, Danielle L Swaney, David Jimenez-Morales, Jeffrey R Johnson, Nicholas E Garelis, Teresa Repasy, Allison W Roberts, Lauren M Popov, Trevor J Parry, Dexter Pratt, Trey Ideker, Nevan J Krogan, Jeffery S Cox
Publikováno v:
eLife, Vol 9 (2020)
Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostasis, but how these distinct cellular fates are triggered by environmental cues is poorly understood. To uncover how primary murine macrophages respond to
Externí odkaz:
https://doaj.org/article/cde5e721c9b14b919299582e8f3eddb4
Autor:
Allison W Roberts, Lauren M Popov, Gabriel Mitchell, Krystal L Ching, Daniel J Licht, Guillaume Golovkine, Gregory M Barton, Jeffery S Cox
Publikováno v:
eLife, Vol 8 (2019)
Macrophages play critical roles in immunity, development, tissue repair, and cancer, but studies of their function have been hampered by poorly-differentiated tumor cell lines and genetically-intractable primary cells. Here we report a facile system
Externí odkaz:
https://doaj.org/article/fd6276c25bcd4e448a17af0bee440ba2
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000767 (2009)
Toxin-antitoxin (TA) systems, stress-responsive genetic elements ubiquitous in microbial genomes, are unusually abundant in the major human pathogen Mycobacterium tuberculosis. Why M. tuberculosis has so many TA systems and what role they play in the
Externí odkaz:
https://doaj.org/article/7c24f51ba05d404b848f86ea7ec61f1e
Autor:
Wilbert Bitter, Edith N G Houben, Daria Bottai, Priscille Brodin, Eric J Brown, Jeffery S Cox, Keith Derbyshire, Sarah M Fortune, Lian-Yong Gao, Jun Liu, Nicolaas C Gey van Pittius, Alexander S Pym, Eric J Rubin, David R Sherman, Stewart T Cole, Roland Brosch
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000507 (2009)
Externí odkaz:
https://doaj.org/article/1efeb760ec434933a447d9ab9dd83d1d
Autor:
Jess H Leber, Gregory T Crimmins, Sridharan Raghavan, Nicole P Meyer-Morse, Jeffery S Cox, Daniel A Portnoy
Publikováno v:
PLoS Pathogens, Vol 4, Iss 1, p e6 (2008)
How the innate immune system tailors specific responses to diverse microbial infections is not well understood. Cells use a limited number of host receptors and signaling pathways to both discriminate among extracellular and intracellular microbes, a
Externí odkaz:
https://doaj.org/article/f63b5b81d4704305a8d289bd10ccf7fd
Autor:
Bryant McLaughlin, Janet S Chon, Jason A MacGurn, Fredric Carlsson, Terri L Cheng, Jeffery S Cox, Eric J Brown
Publikováno v:
PLoS Pathogens, Vol 3, Iss 8, p e105 (2007)
Specialized secretion systems of pathogenic bacteria commonly transport multiple effectors that act in concert to control and exploit the host cell as a replication-permissive niche. Both the Mycobacterium marinum and the Mycobacterium tuberculosis g
Externí odkaz:
https://doaj.org/article/5b2a982e2b4542f296069f40257f8912
Autor:
Andrew E Greenstein, Jason A MacGurn, Christina E Baer, Arnold M Falick, Jeffery S Cox, Tom Alber
Publikováno v:
PLoS Pathogens, Vol 3, Iss 4, p e49 (2007)
Receptor Ser/Thr protein kinases are candidates for sensors that govern developmental changes and disease processes of Mycobacterium tuberculosis (Mtb), but the functions of these kinases are not established. Here, we show that Mtb protein kinase (Pk
Externí odkaz:
https://doaj.org/article/9bd8349551f84deeb318054388395c9b
Autor:
Madhulika Jain, Jeffery S Cox
Publikováno v:
PLoS Pathogens, Vol 1, Iss 1, p e2 (2005)
Virulent mycobacteria utilize surface-exposed polyketides to interact with host cells, but the mechanism by which these hydrophobic molecules are transported across the cell envelope to the surface of the bacteria is poorly understood. Phthiocerol di
Externí odkaz:
https://doaj.org/article/feeea32e42a54fd8bca50feadbaefb0e