Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeffery R. Deschamps"'
Autor:
Jenny Lam, Jeffery R. Deschamps, Adrian M. Guerrero, Greg H. Imler, Francisco O. Battiti, Alessandro Bonifazi, Sophie L. Cemaj, Rana Rais, Anver Basha Shaik, Barbara S. Slusher, Amy Hauck Newman
Publikováno v:
Journal of Medicinal Chemistry. 62:6287-6314
Because of the large degree of homology among dopamine D2-like receptors, discovering ligands capable of discriminating between the D2, D3, and D4 receptor subtypes remains a significant challenge....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3a86887c560fec57c3c2a409306d8d7
https://doi.org/10.1021/acs.jmedchem.9b00702
https://doi.org/10.1021/acs.jmedchem.9b00702
Autor:
Francisco O, Battiti, Sophie L, Cemaj, Adrian M, Guerrero, Anver Basha, Shaik, Jenny, Lam, Rana, Rais, Barbara S, Slusher, Jeffery R, Deschamps, Greg H, Imler, Amy Hauck, Newman, Alessandro, Bonifazi
Publikováno v:
J Med Chem
Due to the large degree of homology among dopamine D(2)-like receptors, discovering ligands capable of discriminating between the D(2), D(3) and D(4) receptor subtypes remains a significant challenge. Previous work has exemplified the use of bitopic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f80576bccab4763a3aff210449f6fbba
https://pubmed.ncbi.nlm.nih.gov/31257877
https://pubmed.ncbi.nlm.nih.gov/31257877
Autor:
Scott A. Walper, George M. Anderson, Kimhiro Susumu, Eunkeu Oh, Jeffery R. Deschamps, Carl W. Brown, Igor L. Medintz, Anthony P. Malanoski, Joyce C. Breger
Publikováno v:
Colloidal Nanoparticles for Biomedical Applications XIII.
Enhancement in enzymatic activity after attachment to nanoparticle surfaces has been observed in numerous enzyme systems, although the underlying mechanism for these enhancements remains largely unknown. This work explores the utility of a model base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c5b9cc1f9a2c3e67fd1fdcf719c92d4
https://doi.org/10.1117/12.2289988
https://doi.org/10.1117/12.2289988
Publikováno v:
Journal of Heterocyclic Chemistry. 50:949-954
4,4′-(Methylenediimino)bis-1,2,5-oxadiazole-3-carboxylic acid and 4,4′-(methylenediimino)bis-1,2,5-oxadiazole-3-carboxamide have been synthesized by the acid-catalyzed condensation of 4-amino-1,2,5-oxadiazole-3-carboxylic acid and 4-amino-1,2,5-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3977b72454a7bb7052a0c636a8a597a2
https://doi.org/10.1002/jhet.1547
https://doi.org/10.1002/jhet.1547
Autor:
Vineetha Vasukuttan, Yanyan Zhang, Jeffery R. Deschamps, Scott P. Runyon, Rangan Maitra, James B. Thomas, Ann M. Decker, Sanju Narayanan, Katherine Bortoff, Keith R. Warner
Publikováno v:
Bioorganicmedicinal chemistry. 24(16)
The apelinergic system includes a series of endogenous peptides apelin, ELABELA/TODDLER and their 7-transmembrane G-protein coupled apelin receptor (APJ, AGTRL-1, APLNR). The APJ receptor is an attractive therapeutic target because of its involvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb6971c1a3780852f6fb120c86af8e5
https://pubmed.ncbi.nlm.nih.gov/27369451
https://pubmed.ncbi.nlm.nih.gov/27369451
Autor:
Rodney L. Willer, Robson F. Storey, Damon A. Parrish, Frank J. J. Leusen, John Kendrick, Jeffery R. Deschamps
Publikováno v:
Crystal Growth & Design. 12:5292-5297
Spiro-cyclic compounds frequently have screw-type symmetry (C2) and are therefore optically active even though they do not contain an asymmetric carbon atom. (R/S)-1,6-Dinitro-3,8-dioxa-1,6-diazaspiro[4.4]nonane-2,7-dione is such a molecule. A blind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66d15e4572ef74408bdf879eea1ea84
https://doi.org/10.1021/cg300869z
https://doi.org/10.1021/cg300869z
Publikováno v:
Journal of Heterocyclic Chemistry. 49:227-231
The crystal structures of the two compounds reported to be 4-aminofurazan-3-carboxylic acid have been determined. The compound reported by Sheremetev et al. (J Heterocycl Chem 2005, 42, 519) is the actual 4-aminofurazan-3-carboxylic acid. The compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7485418904de9e150d14f89ee61ac638
https://doi.org/10.1002/jhet.821
https://doi.org/10.1002/jhet.821
Autor:
Weiming Luo, Nigel H. Greig, Arnold Brossi, Yazhou Li, Jeffery R. Deschamps, Damon A. Parrish, David Tweedie, Qian-Sheng Yu, Harold W. Holloway
Publikováno v:
Synthesis. 2008:3415-3422
A resurgence of interest in thalidomide has occurred as a consequence of its diverse immunomodulatory and anticancer actions, which has fuelled interest in synthetic analogues with higher potencies or less undesirable side effect profiles. Several no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17afac1f78d281c17d7e58883a584d9
https://doi.org/10.1055/s-0028-1083179
https://doi.org/10.1055/s-0028-1083179
Autor:
Jianming Yu, Xiaoxiang Liu, Xiangyu Z. Wearing, Hui Cao, Jeffery R. Deschamps, James M. Cook, Chunchun Zhang
Publikováno v:
Tetrahedron Letters. 44:8013-8017
The stereospecific synthesis of (−)-koumidine was realized by replacement of triphenylphosphine with tricyclohexylphosphine in the enolate driven palladium-catalyzed cross coupling process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79a7bb464df3183790eeb33431aef38
https://doi.org/10.1016/j.tetlet.2003.08.072
https://doi.org/10.1016/j.tetlet.2003.08.072
Autor:
Jianjing Cao, Vivek Kumar, Amy Hauck Newman, Ashwini K. Banala, Alessandro Bonifazi, Thomas M. Keck, Erick G. Garcia, Jeffery R. Deschamps
The improved chiral synthesis of the selective dopamine D3 receptor (D3R) antagonist (R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)1H-indole-2-carboxamide (( R )-PG648) is described. The same chiral secondary alcohol intermediate was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a329ba834b5c3e0ab54d921eb9f4de
https://europepmc.org/articles/PMC4060923/
https://europepmc.org/articles/PMC4060923/
