Výsledky vyhledávání - "Jeffery Mark Brown"

In Silico Reagent Design for Electron-Transfer Dissociation on a Q-TOF

Autor: Keith Richardson, Jeffery Mark Brown

Publikováno v: Journal of the American Society for Mass Spectrometry. 32:2092-2098

Electron-transfer dissociation is an important technique capable of probing the primary and higher order structure of a wide variety of biomolecules and yielding information that is often inaccessible using other common MS methods. The source of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb185df3b401284043dc105a88ef3189
https://doi.org/10.1021/jasms.0c00483

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Coupling 193 nm Ultraviolet Photodissociation and Ion Mobility for Sequence Characterization of Conformationally-Selected Peptides

Autor: Sophie R. Harvey, Vicki H. Wysocki, Bruno Bellina, Jeffery Mark Brown, Alyssa Q. Stiving, Perdita E. Barran, Benjamin J. Jones

Publikováno v: J Am Soc Mass Spectrom

Ultraviolet photodissociation (UVPD) has emerged as a useful technique for characterizing peptide, protein, and protein complex primary and secondary structure. 193 nm UVPD, specifically, enables extensive covalent fragmentation of the peptide backbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2193675d16b94c2b962920f02ce47962
https://doi.org/10.1021/jasms.0c00259

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Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer

Autor: Valery G. Voinov, Jeffery Mark Brown, Lindsay J. Morrison, Joseph S. Beckman, Frederik Lermyte, Jonathan P. Williams

Publikováno v: Anal Chem

Electron-based fragmentation methods have revolutionized biomolecular mass spectrometry, in particular native and top-down protein analysis. Here, we report the use of a new electromagnetostatic cell to perform electron capture dissociation (ECD) wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c359a84a3ecd0aaea992d8617b89f33
https://doi.org/10.1021/acs.analchem.9b04763

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Advancing Liquid Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Toward Ultrahigh-Throughput Analysis

Autor: Evita Hartmane, Henriette Krenkel, Cristian Piras, Rainer Cramer, Jeffery Mark Brown, Michael Morris

Publikováno v: Analytical Chemistry

Label-free high-throughput screening using mass spectrometry has the potential to provide rapid large-scale sample analysis at a speed of more than one sample per second. Such speed is important for compound library, assay and future clinical screeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92bf69d6502f6dc59170eb84b851d25
https://doi.org/10.1021/acs.analchem.9b05202

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Surface-induced dissociation of protein complexes on a cyclic ion mobility spectrometer

Autor: Jason Wildgoose, Darren Hewitt, Jeffery Mark Brown, Yu-Fu Lin, Dale Cooper-Shepherd, Dalton T. Snyder, Vicki H. Wysocki, James I. Langridge, Benjamin J. Jones

Publikováno v: The Analyst

We describe the implementation of a simple three-electrode surface-induced dissociation (SID) cell on a cyclic ion mobility spectrometer (cIMS) and demonstrate the utility of multipass mobility separations for resolving multiple conformations of prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d758fa1b8c91c02a2e67670112dc8cc6
https://pubmed.ncbi.nlm.nih.gov/34632987

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Characterization of native protein structure with ion mobility mass spectrometry, multiplexed fragmentation strategies and multivariant analysis

Autor: Jeffery Mark Brown, Alexey Barkhanskiy, Drupad K. Trivedi, Bruno Bellina, Rachelle Black, Lennart A I Ramakers, Alina Theisen, Perdita E. Barran

Publikováno v: Black, R, Barkhanskiy, A, Ramakers, L A I, Theisen, A, Brown, J M, Bellina, B, Trivedi, D K & Barran, P E 2021, ' Characterization of native protein structure with ion mobility mass spectrometry, multiplexed fragmentation strategies and multivariant analysis ', International Journal of Mass Spectrometry, vol. 464, pp. 116588 . https://doi.org/10.1016/j.ijms.2021.116588
International Journal of Mass Spectrometry

Activated ion mobility measurements provide insights to the stability of tertiary and quaternary structures of proteins and when coupled with dissociation strategies can delineate how the fold is disrupted. In this work, we use 213 nm photodissociati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e78d0a96808e377dd3acebc9317f7f2
https://www.research.manchester.ac.uk/portal/en/publications/characterization-of-native-protein-structure-with-ion-mobility-mass-spectrometry-multiplexed-fragmentation-strategies-and-multivariant-analysis(8f275383-44de-4f6d-bf73-e96f6ac16737).html

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Characterization of Protein Structure with Ion Mobility Mass Spectrometry, Multiplexed Fragmentation Strategies and Data Directed Analysis

Autor: Black R, Trivedi D, Jeffery Mark Brown, Alina Theisen, Perdita E. Barran, Ramakers L, Bruno Bellina, Barkhanskiy A

Activated ion mobility measurements provide Insights to the stability of tertiary and quaternary structures of proteins and pairing such approaches with fragmentation can delineate which part(s) of the primary sequence are disrupted from a folded str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f83f6e85f4bffa792637ad1d13998b48
https://doi.org/10.26434/chemrxiv.13205918.v1

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The matrix-assisted laser desorption/ionisation in-source decay of peptides using ion mobility enabled quadrupole-time-of-flight mass spectrometry

Autor: Martin Hubálek, Vladimír Vrkoslav, Jeffery Mark Brown, Josef Cvačka, Alexander Muck

Publikováno v: Rapid Communications in Mass Spectrometry. 32:2099-2105

RATIONALE In-source decay (ISD) matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry with a 1,5-diaminonaphthalene (1,5-DAN) matrix is used for the structural characterisation of peptides. However, MALDI spectra are intrinsically com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec24617428e4d814e6ebb58b9eb67e7e
https://doi.org/10.1002/rcm.8284

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Electron transfer with no dissociation ion mobility–mass spectrometry (ETnoD IM-MS). The effect of charge reduction on protein conformation

Autor: Rebecca Beveridge, Jonathan P. Williams, Jeffery Mark Brown, Eleanor R. Dickinson, Bruno Bellina, Jacquelyn R. Jhingree, Perdita E. Barran

Publikováno v: Jhingree, J, Beveridge, R, Dickinson, E, Williams, J P, Brown, J M, Bellina, B & Barran, P 2017, ' Electron transfer with no dissociation ion mobility-mass spectrometry (ETnoD IM-MS) The effect of charge reduction on protein conformation ', International Journal of Mass Spectrometry, vol. 413 . https://doi.org/10.1016/j.ijms.2016.08.006

A novel mass spectrometry approach is reported which investigate how ion-molecule charge reduction reactions between radical anions and protein cations modulate protein conformation. An electron transfer reagent (1,3-dicyanobenzene) transfers electro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43833476bf323b8f5043f9b3a419ee82
https://doi.org/10.1016/j.ijms.2016.08.006

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Electron Transfer Dissociation of All Ions at All Times, MSETD, in a Quadrupole Time-of-Flight (Q-ToF) Mass Spectrometer

Autor: Nick Tomczyk, Kim F. Haselmann, Jeffery Mark Brown, Christian N. Cramer, Peter Kresten Nielsen

Publikováno v: Journal of the American Society for Mass Spectrometry. 28:384-388

Data-independent mass spectral acquisition is particularly powerful when combined with ultra-performance liquid chromatography (LC) that provides excellent separation of most components present in a given sample. Data-independent analysis (DIA) consi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c71610165647e1a190d1aa826c1f8e2c
https://doi.org/10.1007/s13361-016-1538-2

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