Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Jeffery M, Schkeryantz"'
1
Structural Basis for (S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor
Autor: Joseph D. Ho, Michelle C. Vargas, Jing Wang, Junliang Hao, Shane Atwell, James A. Monn, Sheela Ashok, Mark G. Bures, Qi Chen, Jeffery M. Schkeryantz
Publikováno v: Journal of Medicinal Chemistry. 61:10040-10052
( S)-3,4-Dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu8 receptor, but the structural basis for its high selectivity is not well understood. We have solved a cocryst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33be9a640f18a032be5e1bd51cd0d5b7
https://doi.org/10.1021/acs.jmedchem.8b01120
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3
Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity
Autor: Jeffery M. Schkeryantz, Qi Chen, Joseph D. Ho, Shane Atwell, Aiping Zhang, Michelle C. Vargas, Jing Wang, James A. Monn, Junliang Hao
Publikováno v: Bioorganicmedicinal chemistry letters. 28(4)
L-2-Amino-4-phosphonobutyric acid (L-AP4) is a known potent and selective agonist for the Group III mGlu receptors. However, it does not show any selectivity among the individual group III mGlu subtypes. In order to understand the molecular basis for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662502c4305171f5c54aa8953f44db3f
https://pubmed.ncbi.nlm.nih.gov/29402739
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Plný text Recenzováno Digitální knihovna AV ČR
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