Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jeffery L. Wrana"'
Autor:
Paul A. Spagnuolo, Aaron D. Schimmer, Joe Quadrilatero, Jamie W. Joseph, Janusz Pawliszyn, Andrea Edginton, Jeffery L. Wrana, Alessandro Datti, Shrivani Sriskanthadevan, Mark Minden, Barbara Bojko, Ezel Boyaci, Marcela Gronda, Xiao Ming Wang, Rose Hurren, Andrew Mitchell, Thomas Hanlon, Sarah-Grace Rota, Leonard Angka, Eric A. Lee
Supplementary Figures S1-S9. Avocatin B is the most active avocado lipid analogue (S1); Kinetics of avocatin B-induced death (S2); Cell cycle analysis of avocatin B treated TEX cells (S3); Avocatin B increases DCFH-DA and DHE (S4); Avocatin B's activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605f187f076ac4f343e40bcbee551bc2
https://doi.org/10.1158/0008-5472.22405770.v1
https://doi.org/10.1158/0008-5472.22405770.v1
Autor:
Paul A. Spagnuolo, Aaron D. Schimmer, Joe Quadrilatero, Jamie W. Joseph, Janusz Pawliszyn, Andrea Edginton, Jeffery L. Wrana, Alessandro Datti, Shrivani Sriskanthadevan, Mark Minden, Barbara Bojko, Ezel Boyaci, Marcela Gronda, Xiao Ming Wang, Rose Hurren, Andrew Mitchell, Thomas Hanlon, Sarah-Grace Rota, Leonard Angka, Eric A. Lee
Legend for Supplementary Figures S1-S9.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ad24094a5421bfed1f3de42d7b75ba
https://doi.org/10.1158/0008-5472.22405773
https://doi.org/10.1158/0008-5472.22405773
Autor:
Paul A. Spagnuolo, Aaron D. Schimmer, Joe Quadrilatero, Jamie W. Joseph, Janusz Pawliszyn, Andrea Edginton, Jeffery L. Wrana, Alessandro Datti, Shrivani Sriskanthadevan, Mark Minden, Barbara Bojko, Ezel Boyaci, Marcela Gronda, Xiao Ming Wang, Rose Hurren, Andrew Mitchell, Thomas Hanlon, Sarah-Grace Rota, Leonard Angka, Eric A. Lee
Supplementary Tables S1-S3. Summary of EC50 values for avocatin B in a panel of AML cell lines (S1); AML patient sample details used for annexin/PI (S2); AML patient sample details used for colony formation assays (S3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16fda7d4d735fb11d6d5fe58353b192
https://doi.org/10.1158/0008-5472.22405764.v1
https://doi.org/10.1158/0008-5472.22405764.v1
Autor:
Paul A. Spagnuolo, Aaron D. Schimmer, Joe Quadrilatero, Jamie W. Joseph, Janusz Pawliszyn, Andrea Edginton, Jeffery L. Wrana, Alessandro Datti, Shrivani Sriskanthadevan, Mark Minden, Barbara Bojko, Ezel Boyaci, Marcela Gronda, Xiao Ming Wang, Rose Hurren, Andrew Mitchell, Thomas Hanlon, Sarah-Grace Rota, Leonard Angka, Eric A. Lee
Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c970e7d064c2dbafbd620b3cdacf2bbc
https://doi.org/10.1158/0008-5472.22405767.v1
https://doi.org/10.1158/0008-5472.22405767.v1
Autor:
Izzy Livne-bar, Monika Sangwan, Jeffery L. Wrana, Rod Bremner, Sean R. McCurdy, Danian Chen, Mohammad Ahmad
Publikováno v:
Oncogene
RB(+/-) individuals develop retinoblastoma and, subsequently, many other tumors. The Rb relatives p107 and p130 protect the tumor-resistant Rb(-/-) mouse retina. Determining the mechanism underlying this tumor suppressor function may expose novel str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a3cb185265fac258ee40aa5c02a850
https://doi.org/10.1038/onc.2011.654
https://doi.org/10.1038/onc.2011.654
Autor:
Tabitha E. Wood, Xinliang Mao, Michael F. Moran, Wenjie Wang, Rose Hurren, Robert A. Batey, Yueping Jin, Alessandro Datti, Jiefei Tong, Xiaoming Wang, Jie Li, Biyin Cao, Jeffery L. Wrana, Wenxian Sun, Neil MacLean, Aaron D. Schimmer, Paul A. Spagnuolo
Publikováno v:
Blood. 117:1986-1997
D-cyclins are universally dysregulated in multiple myeloma and frequently overexpressed in leukemia. To better understand the role and impact of dysregulated D-cyclins in hematologic malignancies, we conducted a high-throughput screen for inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be75256ed171f9b3ddcfd29180074c7f
https://doi.org/10.1182/blood-2010-05-284810
https://doi.org/10.1182/blood-2010-05-284810
Autor:
E Walford, Payman Samavarchi-Tehrani, Jeffery L. Wrana, Sean P. Scully, Susanna P. Garamszegi, Nandor Garamszegi, M M Schneiderbauer
Publikováno v:
Oncogene. 29:2368-2380
Matrix remodeling, degradation, inflammation and invasion liberate peptide fragments that can subsequently interact with cells in an attachment-independent manner. Such 'soluble' matrix components, including collagens, fibronectin and laminin, induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09e1a44e3f21cdba61ad5eacf9ed47b
https://doi.org/10.1038/onc.2009.514
https://doi.org/10.1038/onc.2009.514
Autor:
Eric A. Lee, Janusz Pawliszyn, Rose Hurren, Sarah-Grace Rota, Shrivani Sriskanthadevan, Joe Quadrilatero, Thomas Hanlon, Marcela Gronda, Ezel Boyacı, Paul A. Spagnuolo, Jamie W. Joseph, Alessandro Datti, Jeffery L. Wrana, Andrew S. Mitchell, Aaron D. Schimmer, Xiaoming Wang, Barbara Bojko, Mark D. Minden, Andrea N. Edginton, Leonard Angka
Publikováno v:
Cancer research. 75(12)
Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a lipid derived from avocado fruit, as a novel compound with cytotoxic activity in AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a574e355ca182b40e576ccb3bb14f86d
https://pubmed.ncbi.nlm.nih.gov/26077472
https://pubmed.ncbi.nlm.nih.gov/26077472
Autor:
Neil MacLean, Rose Hurren, Lin Fh, Alessandro Datti, Jeffery L. Wrana, Marcela Gronda, Aaron D. Schimmer, Paul A. Spagnuolo, Xiaoming Wang, Basheer A
Parthenolide is selectively toxic to leukemia cells; however, it also activates cell protective responses that may limit its clinical application. Therefore, we sought to identify agents that synergistically enhance parthenolide's cytotoxicity. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef0b67d2427c25a70b8a03a5a232929
http://hdl.handle.net/11391/1069068
http://hdl.handle.net/11391/1069068
Autor:
James Kasper, Donna E. Hogge, Liliana Attisano, Anh Chau, Ratheesh Subramaniam, Methvin Isaac, Jeffery L. Wrana, Bryan W. Miller, Yulia Jitkova, Ahmed Aman, Solmaz Alizadeh, Aaron D. Schimmer, Marcela Gronda, Stephen Perusini, Siyuan Song, Babu Joseph, Rima Al-awar, Scott Weir, Rose Hurren, Tania Christova, Ren-Yue Bao
Publikováno v:
Cancer research. 71(24)
Excessive signaling from the Wnt pathway is associated with numerous human cancers. Using a high throughput screen designed to detect inhibitors of Wnt/β-catenin signaling, we identified a series of acyl hydrazones that act downstream of the β-cate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6e368beb831e902764ec07fc328ee8
https://pubmed.ncbi.nlm.nih.gov/22009536
https://pubmed.ncbi.nlm.nih.gov/22009536