Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jeffery L Smith"'
Autor:
Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Han Wee Ong, Yi Lang, William Richardson, Josie A Silvaroli, Frances M Bashore, Jeffery L Smith, Isabelle M Genereux, Kelvin Dempster, David H Drewry, Navlot S Pabla, Alex N Bullock, Tim A Benke, Sila K Ultanir, Alison D Axtman
Publikováno v:
eLife, Vol 12 (2023)
Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (CDKL5) cause CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder associated with severe and medically refractory early-life epilepsy, motor, cogniti
Externí odkaz:
https://doaj.org/article/1bf476386b1149818536f2b15c6067c9
Autor:
Zachary W. Davis-Gilbert, Andreas Krämer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Frances M. Bashore, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, Udo Oppermann, David H. Drewry, Alison D. Axtman
Publikováno v:
ACS Medicinal Chemistry Letters. 14:432-441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6c8409e0512fd44b783dd45f86d23ef
https://doi.org/10.1021/acsmedchemlett.2c00530
https://doi.org/10.1021/acsmedchemlett.2c00530
Autor:
Molly M. Simmons, Sonya Gabrielian, Thomas Byrne, Megan B. McCullough, Jeffery L. Smith, Thom J. Taylor, Tom P. O’Toole, Vincent Kane, Vera Yakovchenko, D. Keith McInnes, David A. Smelson
Publikováno v:
Implementation Science, Vol 12, Iss 1, Pp 1-10 (2017)
Abstract Background Homeless veterans often have multiple health care and psychosocial needs, including assistance with access to housing and health care, as well as support for ongoing treatment engagement. The Department of Veterans Affairs (VA) de
Externí odkaz:
https://doaj.org/article/52b6e87db61f48dab20abc604e4ab18b
Autor:
David H. Drewry, Frances M. Potjewyd, Armin Bayati, Jeffery L. Smith, Rebekah J. Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M. Min, Mohammad Anwar Hossain, Mark Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman
Publikováno v:
Journal of Medicinal Chemistry. 65:12860-12882
From a designed library of indolyl pyrimidinamines, we identified a highly potent and cell-active chemical probe (17) that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve). Comprehensive evaluation of inhibitor selectivity confirmed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d43a4012ef9586e714a008decfeffd9
https://doi.org/10.1021/acs.jmedchem.2c00697
https://doi.org/10.1021/acs.jmedchem.2c00697
Autor:
Xuan Yang, Han Wee Ong, Rebekah J. Dickmander, Jeffery L. Smith, Jason W. Brown, William Tao, Edcon Chang, Nathaniel J. Moorman, Alison D. Axtman, Timothy M. Willson
Publikováno v:
bioRxiv
3-cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines, including the chemical probe SGC-CK2-1, are potent and selective inhibitors of CSNK2A in cells but have limited utility in animal models due to their poor pharmacokinetic properties. While develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9729a48b7b203fcf0442ab3f1d93b3
https://europepmc.org/articles/PMC10245575/
https://europepmc.org/articles/PMC10245575/
Autor:
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, James D. Vasta, Matthew B. Robers, Timothy M. Willson
Publikováno v:
bioRxiv
Molecules; Volume 28; Issue 7; Pages: 2950
Molecules; Volume 28; Issue 7; Pages: 2950
PLK1 is a protein kinase that regulates mitosis and is both an important oncology drug target and a potential antitarget of drugs for the DNA damage response pathway or anti-infective host kinases. To expand the range of live cell NanoBRET target eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b9db4eef90bd369ed86b4803dc3bc0
https://europepmc.org/articles/PMC9980182/
https://europepmc.org/articles/PMC9980182/
Autor:
Han Wee Ong, Yi Liang, William Richardson, Emily R. Lowry, Carrow I. Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A. Silvaroli, Jeffery L. Smith, Hynek Wichterle, Navjot S. Pabla, Sila K. Ultanir, Alex N. Bullock, David H. Drewry, Alison D. Axtman
Publikováno v:
bioRxiv
Despite mediating several essential processes in the brain, including during development, cyclin-dependent kinase-like 5 (CDKL5) remains a poorly characterized human protein kinase. Accordingly, its substrates, functions, and regulatory mechanisms ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbfb1603d4bbbd78dfe7ffaa08e876
https://doi.org/10.1101/2023.02.09.527935
https://doi.org/10.1101/2023.02.09.527935
Autor:
Zachary W. Davis-Gilbert, Andreas Krämer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, Udo Oppermann, David H. Drewry, Alison D. Axtman
Naphthyridine-based inhibitors were synthesized to yield a potent and cell-active inhibitor of casein kinase 2 (CK2). Compound 2 selectively inhibits CK2⍺ and CK2⍺’ when profiled broadly, making it an exquisitely selective chemical probe for CK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6e3cb4f21086664bb345ae5a84821e
https://doi.org/10.26434/chemrxiv-2022-05jcz
https://doi.org/10.26434/chemrxiv-2022-05jcz
Phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ), which phosphorylates phosphatidylinositol-5-monophosphate (PI(5)P), is a human lipid kinase with intriguing roles in inflammation, T cell activation, autophagy regulation, immunity, heart fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99a64032e07025b59a864fd425f5093
https://doi.org/10.1101/2022.09.08.507203
https://doi.org/10.1101/2022.09.08.507203
Autor:
Frances M. Bashore, Ariana B. Marquez, Apirat Chaikuad, Stefanie Howell, Andrea S. Dunn, Alvaro A. Beltran, Jeffery L. Smith, David H. Drewry, Adriana S. Beltran, Alison D. Axtman
Tau tubulin kinase 1 and 2 (TTBK1/2) are highly homologous kinases that are expressed and mediate disease-relevant pathways predominantly in the brain. Distinct roles for TTBK1 and TTBK2 have been delineated. While efforts have been devoted to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e1ec78f08076ac35a871982ef767b3
https://doi.org/10.1101/2022.05.06.490937
https://doi.org/10.1101/2022.05.06.490937