Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jeffery L, Keene"'
Autor:
Kranti A. Mapuskar, Emily J. Steinbach, Amira Zaher, Dennis P. Riley, Robert A. Beardsley, Jeffery L. Keene, Jon T. Holmlund, Carryn M. Anderson, Diana Zepeda-Orozco, John M. Buatti, Douglas R. Spitz, Bryan G. Allen
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1329 (2021)
Cisplatin is a chemotherapy agent commonly used to treat a wide variety of cancers. Despite the potential for both severe acute and chronic side effects, it remains a preferred therapeutic option for many malignancies due to its potent anti-tumor act
Externí odkaz:
https://doaj.org/article/0021957feb484ccdac2aff962e27ea4a
Autor:
Shelton D. Caruthers, Samuel A. Wickline, Patrick M. Winter, Anne H. Schmieder, Huiying Zhang, Jeffery L. Keene, Gregory M. Lanza
Publikováno v:
The FASEB Journal. 22:2758-2767
Fumagillin suppresses angiogenesis in cancer models and clinical trials, but it is associated with neurotoxicity at systemic doses. In this study, ανβ3-targeted fumagillin nanoparticles were used to suppress the neovasculature and inhibit Vx-2 ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2ceba20c148bfdc4e41397b62b593e
https://doi.org/10.1096/fj.07-103929
https://doi.org/10.1096/fj.07-103929
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034
https://doi.org/10.1016/j.bmc.2007.03.034
Autor:
Srinivasan Nagarajan, Ish K. Libertyville Khanna, Tiffany Duffin, Alan F. Gasiecki, Jeffery L. Keene, Mihir D. Parikh, Michael Clare, Marisa M. Westlin, Maureen A. Nickols, Christina A. Steininger, Melanie L. Williams, Hwang-Fun Lu, Thomas Rogers, Jon A. Klover, Mary Beth Finn, V. Wayne Engleman, Sandra K. Freeman, William F. Westlin, Barbara B. Chen, G. Alan Nickols, Kristen E. Shannon, Mark A. Russell, Bipinchandra N. Desai
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3390-3412
The integrin alpha(v)beta(3) is expressed in a number of cell types and is thought to play a major role in several pathological conditions. Various small molecules that inhibit the integrin have been shown to suppress tumor growth and retinal angioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76977820b693cad5d5c26a6da2d6f596
https://doi.org/10.1016/j.bmc.2007.03.020
https://doi.org/10.1016/j.bmc.2007.03.020
Autor:
Tiffany Duffin, Maureen A. Nickols, Barbara B. Chen, Mary Beth Finn, Mark A. Russell, William F. Westlin, Steven L. Settle, Mark L. Boys, Randall K. Rader, Jon A. Klover, Wang Yaping, Thomas D. Penning, Jeffery L. Keene, V. Wayne Engleman, G. Allen Nickols, Christina N. Steininger, Sandra K. Freeman, Melanie L. Hanneke, Khilevich Albert, Marisa M. Westlin, Kristen E. Shannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3156-3161
We describe a series of pyrazole and isoxazole analogs as antagonists of the α v β 3 receptor. Compounds showed low to sub-nanomolar potency against α v β 3 , as well as good selectivity against α IIb β 3 . In HT29 cells, most analogs also demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e27cd8fc7dca2f6785f6b7c08e8bda4
https://doi.org/10.1016/j.bmcl.2006.03.045
https://doi.org/10.1016/j.bmcl.2006.03.045
Autor:
Mary Beth Finn, Hongwei Wu, Kristen E. Shannon, V. Wayne Engleman, Maureen A. Nickols, Jon A. Klover, Marissa Westlin, Tiffany Duffin, Christina N. Steininger, G. Allen Nickols, Thomas D. Penning, Melanie L. Hanneke, John A. Wendt, Heather Stenmark, Mark A. Russell, Jeffery L. Keene, Downs Victoria Leigh, William F. Westlin, Barbara B. Chen, Wang Yaping, Sandra K. Freeman, Mark L. Boys
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:845-849
We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the other integrins, such as alpha(IIb)beta3 and alpha(v)beta6. These analogs were demonstrated to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9341668d602c5606e629cc594893da77
https://doi.org/10.1016/j.bmcl.2005.11.017
https://doi.org/10.1016/j.bmcl.2005.11.017
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f9513e934e8bf576a289475c31d0e
https://doi.org/10.1016/j.bmcl.2005.11.008
https://doi.org/10.1016/j.bmcl.2005.11.008
Autor:
Christina M. Schmidt, David W. Griggs, Jeffery L. Keene, William F. Westlin, G. Allen Nickols, Steven L. Settle
Publikováno v:
Clinical and Experimental Metastasis. 17:537-544
Studies of metastasis can be accelerated and provide more mechanistic information using cell lines which reproducibly and aggressively metastasize, and which are accurately and easily detected in tissues at all stages of the metastatic process. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16894259a1da698e826b36eda484b8a8
https://doi.org/10.1023/a:1006719800907
https://doi.org/10.1023/a:1006719800907
Autor:
Tucker Collins, Jon J. Schmuke, Songmei Yin, James H. Williams, Kaizhi Guo, Eunhee S. Yi, Jeffery L. Keene, Joseph K. Welply, Daniel G. Remick, Thomas R. Ulich, Susan C. Howard, Christina N. Steininger
Publikováno v:
Inflammation. 18:389-398
E-selectin is an inducible endothelial adhesion molecule that binds neutrophils. E-selectin mRNA is not constitutively detectable in the lungs of rats. Intratracheal injection of LPS induces pulmonary E-selectin mRNA expression at 2–4 h. Intratrach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642b76cd542a45d3d15e72c711203ca4
https://doi.org/10.1007/bf01534436
https://doi.org/10.1007/bf01534436
Autor:
Michael J. Scott, Todd A. Williams, Samuel A. Wickline, John S. Allen, Gregory M. Lanza, Shelton D. Caruthers, Anne H. Schmieder, Jeffery L. Keene
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a2483190ce28ec2b4c04beaa0b22da4
https://doi.org/10.1096/fasebj.22.1_supplement.898.42
https://doi.org/10.1096/fasebj.22.1_supplement.898.42