Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jeffery J. Wheeler"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 68-81 (2022)
Abstract PB2452, a neutralizing monoclonal antibody fragment that binds the antiplatelet drug ticagrelor with high affinity, is being developed as a ticagrelor reversal agent. To identify a clinically useful intravenous (i.v.) reversal regimen, a sem
Externí odkaz:
https://doaj.org/article/3e7338ad061341cea154acaa06cfce5c
Autor:
Cheryl R. Killingsworth, Raymond E. Ideker, John K. Gibson, Donald McAfee, Jian Huang, Jeffery J Wheeler, Marlowe J. Schneidkraut, Jeff Bechard
Publikováno v:
Journal of Cardiovascular Pharmacology. 57:302-307
Vernakalant is a novel antiarrhythmic agent that has demonstrated clinical efficacy for the treatment of atrial fibrillation. Vernakalant blocks, to various degrees, cardiac sodium and potassium channels with a pattern that suggests atrial selectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab48dd383adf6c694f815c4ec0185008
https://doi.org/10.1097/fjc.0b013e3182073c94
https://doi.org/10.1097/fjc.0b013e3182073c94
Publikováno v:
Cancer Research. 65:1497-1504
Integrin-linked kinase (ILK) couples integrins and growth factors to downstream signaling pathways involving phosphatidylinositol 3-kinase, protein kinase B/Akt (PKB/Akt), and glycogen synthase kinase-3β. The anticancer effects of ILK inhibitor QLT0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d1cc5ba707853d6f2948ff19c6f0da
https://doi.org/10.1158/0008-5472.can-04-2940
https://doi.org/10.1158/0008-5472.can-04-2940
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1558-1564
A stable lipid-based carrier system containing a triacylglycerol core has been developed. This has been achieved by homogenization of corn oil (primarily triacylglycerol) in the presence of phosphatidylcholine (PC), preformed 100 nm liposomes prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee1f0268c1eb27e9236799cc40f8a1a
https://doi.org/10.1002/jps.2600831108
https://doi.org/10.1002/jps.2600831108
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1149:329-338
The uptake of the anticancer agent doxorubicin into large unilamellar vesicles (LUVs) exhibiting a transmembrane pH gradient (inside acidic) has been investigated using both kinetic and equilibrium approaches. It is shown that doxorubicin uptake into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce8422762fbe99322dd3e935b5a65ae
https://doi.org/10.1016/0005-2736(93)90218-o
https://doi.org/10.1016/0005-2736(93)90218-o
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1086:310-316
sn-1 Palmitoyl lysophosphatidylinositol is found in carrot suspension culture cells and can be phosphorylated to [32P]lysophosphatidylinositol monophosphate (LPIP) when [gamma 32P]ATP is added to isolated membranes. Based on in vivo labeling studies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836194d2b8e120574591d2d3960af144
https://doi.org/10.1016/0005-2760(91)90175-h
https://doi.org/10.1016/0005-2760(91)90175-h
Publikováno v:
Lipids. 25:328-334
Inositol phospholipids from carrot cell membranes grown in suspension cultured were purified by thinlayer chromatography (TLC) or column chromatography and tentatively identified by co-migration on TLC with animal inositol phospholipid standards. For
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a88003e93b92a8ed9c2b06d1252d4e
https://doi.org/10.1007/bf02544342
https://doi.org/10.1007/bf02544342
Publikováno v:
Journal of drug targeting. 7(6)
A previous study has shown that plasmid DNA can be encapsulated in lipid particles (SPLP, "stabilized plasmid lipid particles") of approximately 70 nm diameter composed of 1,2-dioleoyl-3-phosphatidyl-ethanolamine (DOPE), the cationic lipid N,N-dioleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a14c0f3779953c21f91b289f214766
https://pubmed.ncbi.nlm.nih.gov/10758914
https://pubmed.ncbi.nlm.nih.gov/10758914
Autor:
Paul Tardi, Peter Scherrer, Y P Zhang, Jeffery J. Wheeler, E C Leng, Laura Sekirov, R Sun, K Clow, Pieter R. Cullis, Edward G. Saravolac
Publikováno v:
Gene therapy. 6(8)
Previous work (Wheeler et al, Gene Therapy 1999; 6: 271-281) has shown that plasmid DNA can be entrapped in 'stabilized plasmid-lipid particles' (SPLP) containing the fusogenic lipid dioleoylphosphatidylethanolamine (DOPE), low levels (5-10 mol%) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a290835e4dffe2fcbfda33deb2b02f90
https://pubmed.ncbi.nlm.nih.gov/10467368
https://pubmed.ncbi.nlm.nih.gov/10467368
Autor:
Roger W. Graham, Ian MacLachlan, Jeffery J. Wheeler, Pieter R. Cullis, Y P Zhang, M. J. Hope, Peter Scherrer, Lorne R. Palmer, M. Ossanlou
Publikováno v:
Gene therapy. 6(2)
A detergent dialysis procedure is described which allows encapsulation of plasmid DNA within a lipid envelope, where the resulting particle is stabilized in aqueous media by the presence of a poly(ethyleneglycol) (PEG) coating. These 'stabilized plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a0554d74b1b593c0a440569b47d2b7
https://pubmed.ncbi.nlm.nih.gov/10435112
https://pubmed.ncbi.nlm.nih.gov/10435112