Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeffery J. Nielsen"'
Autor:
Jeffery J. Nielsen, Stewart A. Low, Christopher Chen, Xinlan Li, Ephraim Mbachu, Lina Trigg, Siyuan Sun, Madeline Tremby, Rahul Hadap, Philip S. Low
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 612 (2024)
Spinal fusions are performed to treat congenital skeletal malformations, spondylosis, degenerative disk diseases, and other pathologies of the vertebrae that can be resolved by reducing motion between neighboring vertebrae. Unfortunately, up to 100,0
Externí odkaz:
https://doaj.org/article/a3b7071675f74c859133e0f99b3529a4
Autor:
Stewart A. Low, Jeffery J Nielsen
Publikováno v:
Curr Osteoporos Rep
PURPOSE OF REVIEW: Compared to the current standard of implanting bone anabolics for fracture repair, bone fracture targeted anabolics would be more effective, less invasive, less toxic and would allow for control over what phase of fracture healing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2643e075d6d63e1a600175ed68603f4c
https://doi.org/10.1007/s11914-020-00604-4
https://doi.org/10.1007/s11914-020-00604-4
Autor:
Philip S. Low, Jiliang Li, Diane R. Wagner, Matthias Clauss, Melissa A. Kacena, Jeffery J Nielsen, Sonali Karnik, Alanna Fennimore, Zachary J. Gunderson, Hunter J Promer, Jonathan W. Lowery, M. Terry Loghmani, Todd O. McKinley
Publikováno v:
World Journal of Stem Cells
Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that suppli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8db35d222dc0061d0ebc2e5784f88e
http://europepmc.org/articles/PMC6600851
http://europepmc.org/articles/PMC6600851
Autor:
Philip S. Low, Mingding Wang, Jeffery J Nielsen, Rahul V. Hadap, Nicholas A. Young, Stewart A. Low, Neal T. Ramseier
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 329
Purpose Although more than 18,000,000 fractures occur each year in the US, methods to promote fracture healing still rely primarily on fracture stabilization, with use of bone anabolic agents to accelerate fracture repair limited to rare occasions wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11defc0506ec6e8e1a278150522d17d4
https://pubmed.ncbi.nlm.nih.gov/33031877
https://pubmed.ncbi.nlm.nih.gov/33031877
Autor:
Philip S. Low, Mohamed S. A. Elsayed, Jeongho Park, Sungtae Park, Chang H. Kim, Jeffery J Nielsen, Yves Pommier, Qingyang Liu, Mark Cushman, Keli Agama
Publikováno v:
J Med Chem
The present account describes the discovery and development of a new benzo[c]pyrrolo[2,3-h][1,6]-naphthyridin-5-one (BPN) JAK inhibitory chemotype that has produced selective JAK inhibitors. Sequential palladium chemistry was optimized for the rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5ccc4eb8ec4a2384f3a80bb20c440b
https://doi.org/10.1021/acs.jmedchem.8b00510
https://doi.org/10.1021/acs.jmedchem.8b00510
Autor:
Mingding Wang, Yoonhee Nam, Madduri Srinivasarao, Stewart A. Low, Jeffery J Nielsen, Soie Park, Philip S. Low
Publikováno v:
Bioconjugate chemistry. 29(11)
Approximately 6.3 million bone fractures occur annually in the United States, resulting in considerable morbidity, deterioration in quality of life, loss of productivity and wages, and sometimes death (e.g., hip fractures). Although anabolic and anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dd7c0c4668f2fe8051651f9b69aef3
https://pubmed.ncbi.nlm.nih.gov/30380292
https://pubmed.ncbi.nlm.nih.gov/30380292
Publikováno v:
Journal of Clinical and Translational Science
OBJECTIVES/SPECIFIC AIMS: The primary objective of this study was to evaluate the performance of a bone fracture targeted systemically administrable bone anabolic as a potential therapeutic for bone fracture repair. Currently all bone fracture repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b45a226dff5c4679c4bf917ad36683
https://doi.org/10.1017/cts.2019.241
https://doi.org/10.1017/cts.2019.241
Autor:
Beverly L. Roeder, Paul R. Reynolds, Jason R. Gassman, Jeffery J Nielsen, Alonzo D. Cook, Nafiseh Poornejad, Ryan J. Morris
Publikováno v:
Journal of Biomaterials Applications. 30:1154-1167
Engineering whole organs from porcine decellularized extracellular matrix and human cells may lead to a plentiful source of implantable organs. Decontaminating the porcine decellularized extracellular matrix scaffolds is an essential step prior to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f1c4fbed6f72e286d1626e86975b8c
https://doi.org/10.1177/0885328215615760
https://doi.org/10.1177/0885328215615760
Autor:
Wang M; Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907 , United States., Park S; Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907 , United States., Nam Y; Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907 , United States., Nielsen J; College of Pharmacy , Purdue University , 575 Stadium Mall Drive , West Lafayette , Indiana 47907 , United States., Low SA; Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907 , United States., Srinivasarao M; Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907 , United States., Low PS; Department of Chemistry , Purdue University , 560 Oval Drive , West Lafayette , Indiana 47907 , United States.; Institute for Drug Discovery , Purdue University , 720 Clinic Drive , West Lafayette , Indiana 47907 , United States.
Publikováno v:
Bioconjugate chemistry [Bioconjug Chem] 2018 Nov 21; Vol. 29 (11), pp. 3800-3809. Date of Electronic Publication: 2018 Nov 09.