Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jeffery J Prusakiewicz"'
Autor:
Terry P. Lybrand, Jeffery J. Prusakiewicz, Christopher W. Moth, Anna L. Blobaum, Dapo Akingbade, Shu Xu, Carol A. Rouzer, Aaron T. Jacobs, Kebreab Ghebreselasie, Lawrence J. Marnett, Mary E. Konkle
Publikováno v:
Biochemistry
The cyclooxygenase enzymes (COX-1 and COX-2) are the therapeutic targets of nonsteroidal anti-inflammatory drugs (NSAIDs). Neutralization of the carboxylic acid moiety of the NSAID indomethacin to an ester or amide functionality confers COX-2 selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2475c7870aa7487b80a363e356f89b57
https://doi.org/10.1021/acs.biochem.5b01222
https://doi.org/10.1021/acs.biochem.5b01222
Autor:
Hassan Rashidzadeh, Anneli Savinainen, Justine Oswald, Elizabeth Spencer, Marita Larsson Cohen, Zhen Lou, Jeffery J Prusakiewicz, Serene Josiah
Publikováno v:
Experimental Eye Research. 189:107836
TAK-639 is a topical, 9–amino acid, synthetic, C-type natriuretic peptide analog in development for the treatment of primary open-angle glaucoma and ocular hypertension. This study investigated the impact of TAK-639 on intraocular pressure (IOP), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff5b8e37f31eb2dfd600623e0ae3be5
https://doi.org/10.1016/j.exer.2019.107836
https://doi.org/10.1016/j.exer.2019.107836
Autor:
Justyna Korczynska, Lemy Tsikna, Zoe Hughes-Thomas, Richard Haworth, Christopher J. Roberts, John Warrack, Steven D. Sorden, Irene Papanicolaou, Rodd Polsky, Eric Dobrzynski, Edit Kurali, Timothy Streit, Thomas Wilde, Jeffery J Prusakiewicz, Brian J Christian, Peter C. Adamson, T Michael Nork, Ian Richard Catchpole, Craig Struble, Caroline Sychterz, James Walford, Chi-Man Tang, Daniel Gibson, Ruud Verrijk, Paul E. Miller, Fiona Cook, Jos Smal
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society
A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9ca6065ba82c3a95211a3152eff24c
https://pubmed.ncbi.nlm.nih.gov/27810558
https://pubmed.ncbi.nlm.nih.gov/27810558
Autor:
Elizabeth Groeber, Joe Palandra, Lori Christine, Jeffery J. Prusakiewicz, Ann D. Wrightstone, Udeni Yapa, Arthur J. Wittwer
Publikováno v:
Analytical Biochemistry. 421:556-565
Fatty acid amide hydrolase (FAAH) is one of the main enzymes responsible for the degradation of the endocannabinoid anandamide (N-arachidonoylethanolamine, AEA). FAAH inhibitors may be useful in treating many disorders involving inflammation and pain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df09005714c2f4906e82b86d5da6ab0
https://doi.org/10.1016/j.ab.2011.10.042
https://doi.org/10.1016/j.ab.2011.10.042
Autor:
Jeffery J. Prusakiewicz, Gwendolyn D. Fate, Richard Voorman, Chrisita Ackermann, Faith M. Williams, Christopher Jewell, N. Ann Payne
Publikováno v:
Toxicology and Applied Pharmacology. 225:221-228
Parabens are esters of 4-hydroxybenzoic acid and used as anti-microbial agents in a wide variety of toiletries, cosmetics and pharmaceuticals. It is of interest to understand the dermal absorption and hydrolysis of parabens, and to evaluate their dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1991aedb97de7eb2e2a458ff3b6c93
https://doi.org/10.1016/j.taap.2007.08.002
https://doi.org/10.1016/j.taap.2007.08.002
Autor:
Christopher Jewell, Jeffery J. Prusakiewicz, N. Ann Payne, Gwendolyn D. Fate, Chrisita Ackermann, Faith M. Williams
Publikováno v:
Toxicology Letters. 173:118-123
Skin esterases serve an important pharmacological function as they can be utilised for activation of topically applied ester prodrugs. Understanding the nature of these enzymes, with respect to their role and local activity, is essential to defining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299e9967fc09fe58d1bf4bbe17d52790
https://doi.org/10.1016/j.toxlet.2007.07.004
https://doi.org/10.1016/j.toxlet.2007.07.004
Autor:
Ahmad H. Al-Mestarihi, Melissa V. Turman, Vincenzo Di Marzo, Andrew Vila, Jeffery J. Prusakiewicz, Heather L. Ball, Lawrence J. Marnett
Publikováno v:
Archives of Biochemistry and Biophysics. 464:260-268
The lipoamino acids and endovanilloids have multiple roles in nociception, pain, and inflammation, yet their biological reactivity has not been fully characterized. Cyclooxygenases (COXs) and lipoxygenases (LOs) oxygenate polyunsaturated fatty acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c5d977d81b476286da9cd2b046c627
https://doi.org/10.1016/j.abb.2007.04.007
https://doi.org/10.1016/j.abb.2007.04.007
Autor:
Jeffery J. Prusakiewicz, Heather M. Harville, Yanhua Zhang, Richard Voorman, Chrisita Ackermann
Publikováno v:
Toxicology. 232:248-256
Parabens ( p -hydroxybenzoate esters) are a group of widely used preservatives in topically applied cosmetic and pharmaceutical products. Parabens display weak associations with the estrogen receptors in vitro or in cell based models, but do exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75073964f56a42156fbc78fad228e57e
https://doi.org/10.1016/j.tox.2007.01.010
https://doi.org/10.1016/j.tox.2007.01.010
Publikováno v:
Current Pharmaceutical Design. 10:659-667
The last decade has witnessed a rapid expansion in our understanding of the mammalian endogenous cannabinoid system. In just a few short years since the discovery of endogenous lipids that serve as cannabinoids in vivo, these molecules have been show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e31c6acacd78f79d6ff1c18a9b1fd1c
https://doi.org/10.2174/1381612043453081
https://doi.org/10.2174/1381612043453081
Autor:
Kevin R. Kozak, Lawrence J. Marnett, Scott W. Rowlinson, Jeffery J. Prusakiewicz, Daniel R. Prudhomme
Publikováno v:
Biochemistry. 42:9041-9049
The endocannabinoid arachidonylethanolamide (AEA, anandamide) is an endogenous ligand for the cannabinoid receptors and has been shown to be oxygenated by cyclooxygenase-2 (COX-2). We examined the structural requirements for COX-mediated, AEA oxygena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a30af63e9f5e30dc2f9f36c764f2896
https://doi.org/10.1021/bi034471k
https://doi.org/10.1021/bi034471k