Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jeffery J Anderson"'
Publikováno v:
Otology & Neurotology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b12dc7459ee363c5e9025c85ae9e360
https://doi.org/10.1097/mao.0000000000003886
https://doi.org/10.1097/mao.0000000000003886
Autor:
Alan C. Foster, Stephanie Szobota, Fabrice Piu, Bonnie E. Jacques, David R. Moore, Victoria A. Sanchez, Jeffery J. Anderson
Publikováno v:
The Journal of the Acoustical Society of America. 151(6)
Currently, there are no approved medicines available for the treatment of hearing loss. However, research over the past two decades has contributed to a growing understanding of the pathological mechanisms in the cochlea that result in hearing diffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38adb87d1b7bb082f6d7233567e119e5
https://pubmed.ncbi.nlm.nih.gov/35778165
https://pubmed.ncbi.nlm.nih.gov/35778165
Autor:
Kenneth S. Maxwell, Gordon McMurry, Jeffery J Anderson, Huiying J. Hou, David M. Baguley, Grant D. Searchfield, Ines Hoffmann, Fabrice Piu, James M Robinson
Publikováno v:
Otology & Neurotology
Objective: To evaluate the safety and exploratory efficacy of intratympanic administration of OTO-313 in patients with tinnitus. Study Design: Single intratympanic injection of OTO-313 evaluated in a randomized, double-blind, placebo-controlled Phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d50feae90a93dbc6c01420ea4140490
Autor:
Theodore M, Kamenecka, Céline, Bonnefous, Steven, Govek, Jean-Michel, Vernier, John, Hutchinson, Janice, Chung, Grace, Reyes-Manalo, Jeffery J, Anderson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4350-4353
Modulation of the metabotropic glutamate subtype 5 (mGlu5) receptor may be useful in the treatment of a variety of central nervous system disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amines as small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adaf2149ac25773b2a8c81552c49696
https://doi.org/10.1016/j.bmcl.2005.06.059
https://doi.org/10.1016/j.bmcl.2005.06.059
Autor:
Mark A. Varney, Nicholas D. P. Cosford, Jeffery J. Anderson, Una Campbell, Margaret J. Bradbury, Deborah F. Chapman, Lida R. Tehrani, Darlene R. Giracello, Christopher D. King, A. M. Strack
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:395-402
The metabotropic glutamate receptor subtype mGlu5 modulates central reward pathways. Many transmitter systems within reward pathways affect feeding. We examined the potential role of mGlu5 in body weight regulation using genetic and pharmacological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52454c9bcd6cc70440ef92af9dbd726a
https://doi.org/10.1124/jpet.104.076406
https://doi.org/10.1124/jpet.104.076406
Autor:
David Smith, James Loy, Joseph P. Hendrick, Kevin M. Felsenstein, Barbara J. Robertson, Jeffery J. Anderson, Jason A. Corsa, Ming Zheng, Benito Munoz, Donna M. Barten, Steven Hansel, Todd A Verdoorn, Valerie Guss, Alice T. Loo, Rex Denton, Craig Polson, Kumar Srinivasan, Jian Wang, Susan B. Roberts, Bowei Wang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:635-643
gamma-Secretase inhibitors are one promising approach to the development of a therapeutic for Alzheimer's disease (AD). gamma-Secretase inhibitors reduce brain beta-amyloid peptide (Abeta), which is believed to be a major contributor in the etiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f50afb3966ea42b061f757a2d07f0c3
https://doi.org/10.1124/jpet.104.075408
https://doi.org/10.1124/jpet.104.075408
Autor:
Benito Munoz, Jeffrey Roger Roppe, Jeffery J. Anderson, Edwin J. Schweiger, Janice Chung, Merryl Cramer, Grace Reyes-Manalo, Lida Tehrani, Xiaohui Jiang, Nicholas D. P. Cosford, Bowei Wang, Theodore M. Kamenecka, Jesse Brodkin, Dehua Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:3993-3996
Structure-activity relationship studies leading to the discovery of a new, orally active mGlu5 receptor antagonist are described. The title compound, 5-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine, is highly potent in vitro, has good in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ed6369ce4ac35bdb8054a29f2c002b
https://doi.org/10.1016/j.bmcl.2004.05.037
https://doi.org/10.1016/j.bmcl.2004.05.037
Autor:
Jeffery J. Anderson, Mark A. Varney, Christopher D. King, Margaret J. Bradbury, Deborah F. Chapman, Greg Holtz, Nicholas D. P. Cosford, Jeffrey R. Roppe, Darlene R. Giracello
Publikováno v:
European Journal of Pharmacology. 473:35-40
In vivo receptor occupancy of mGlu5 receptor antagonists was quantified in rat and mouse brain using the mGlu5 receptor selective antagonist [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine) ([3H]methoxy-PEPy). Administration of [3H]methoxy-PEPy (50 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be033af1806d2538cfdab7fc5078019
https://doi.org/10.1016/s0014-2999(03)01935-6
https://doi.org/10.1016/s0014-2999(03)01935-6
Autor:
Linda J. Bristow, Blake A. Rowe, Mark A. Varney, Jean-Michel Vernier, Lucia D Correa, Daniel S. Lorrain, Dana E. Rodriguez, Christopher Baccei, Jeffery J. Anderson, Una Campbell, Hervé Schaffhauser, Anthony B. Pinkerton
Publikováno v:
Neuropsychopharmacology. 28:1622-1632
Group II mGlu receptor agonists (eg LY379268 and LY354740) have been shown to reverse many of the behavioral responses to PCP as well as glutamate release elicited by PCP and ketamine. In the present set of experiments, we used in vivo microdialysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d3b1f9c253ba493db23feeebb2f68c
https://doi.org/10.1038/sj.npp.1300238
https://doi.org/10.1038/sj.npp.1300238
Autor:
Darlene R. Giracello, Blake A. Rowe, Nicholas D. P. Cosford, Mark A. Varney, Deborah F. Chapman, Margaret J. Bradbury, Jeffery J. Anderson, Lida R. Tehrani, Greg Holtz, Sara P. Rao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 303:1044-1051
The binding of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (methoxymethyl-MTEP), a potent and selective antagonist for metabotropic glutamate (mGlu)5 receptors, was characterized in rat brain both in vitro and in vivo. Nonspecifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02261e288431280fa923c3e0993cf6e7
https://doi.org/10.1124/jpet.102.040618
https://doi.org/10.1124/jpet.102.040618