Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jeffery I Everitt"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0292189 (2024)
Mice engineered with a G12D versus Q61R mutation in Kras exhibited differences in tumorigenesis. Namely, the incidence or grade of oral or forestomach squamous epithelial lesions was more prevalent in the KrasG12D background while hematolymphopoietic
Externí odkaz:
https://doaj.org/article/6c125ce0938544da835593d2ab1a6bbe
Autor:
Christine E Crute, Chelsea D Landon, Angela Garner, Samantha M Hall, Jeffery I Everitt, Sharon Zhang, Bevin Blake, Didrik Olofsson, Henry Chen, Heather M Stapleton, Susan K Murphy, Liping Feng
Publikováno v:
Toxicological Sciences. 191:239-252
Perfluorobutanesulfonic acid (PFBS) is a replacement for perfluorooctanesulfonic acid (PFOS) that is increasingly detected in drinking water and human serum. Higher PFBS exposure is associated with risk for preeclampsia, the leading cause of maternal
Publikováno v:
Genes, Chromosomes and Cancer. 38:349-356
Eker rats carry a defect in the Tsc-2 tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely rese
Publikováno v:
Toxicological Sciences. 61:176-186
tert-Butyl alcohol (TBA) has been shown to cause kidney tumors in male rats following chronic administration in drinking water. The objective of the present study was to determine whether TBA induces alpha 2u-globulin (alpha 2u) nephropathy (alpha 2u
Publikováno v:
Molecular Carcinogenesis. 14:28-36
Somatic events leading to the inactivation of tumor suppressor genes often involve chromosomal alterations that can be detected as loss of heterozygosity (LOH). In the Eker rat, spontaneous tumors of the kidney, uterus, and spleen develop as a result