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pro vyhledávání: '"Jeffery C. Mihaichuk"'
Autor:
and David P. Sebesta, Randall S. Smith, Wolfgang Pieken, Gretchen M. Pratt, Kurt Vagle, Christopher J. Tompkins, T. Brian Hurley, John Yegge, Jeffery C. Mihaichuk
Publikováno v:
Organic Process Research & Development. 4:214-224
Presented is a conceptually novel approach to oligonucleotide synthesis referred to herein as dimethoxytrityl resin product anchored sequential synthesis (DMT PASS). The DMT PASS process is characterized by the reaction of a 3‘-protected nucleoside
Publikováno v:
Analytical chemistry. 74(6)
The application of Fourier transform infrared (FT-IR) spectroscopy to the quantitation of effective nucleoside loading on a solid support, via detection of a reaction intermediate, was developed. 4,5-Dicyanoimidazole (DCI) activator is reacted with a