Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jeffery Bostwick"'
Autor:
Pancras C Wong, Carol Watson, Jeffery Bostwick, Jacques Banville, Ruth Wexler, Scott Priestley, Anne Marinier, Michel Bouvier, David Gordon, William Schumacher, Jing Yang
Publikováno v:
Stroke. 47
Introduction: BMS-986120 (BMS) is a novel orally-active antagonist of protease-activated receptor-4 (PAR4), a human platelet thrombin receptor, and is in phase I clinical trial. The antithrombotic potential of BMS was studied in models of electricall
Autor:
Robert J. Leadley, Charles Kasiewski, Tara Wentz, Glenda E. Bilder, Jeffery Bostwick, Mark H. Perrone, Saul J. Needle, Betsey O’Conner, Christopher T. Dunwiddie, Lisa Byan, Kenneth Page, Helen Galczenski, Linda Merkel, Persons Paul E, Myers Michael R, Alfred P. Spada, Amin Dilip, Cuong Ly
Publikováno v:
Circulation. 99:3292-3299
Background —Platelet-derived growth factor (PDGF), a purported mediator of arterial response to injury, stimulates proliferation, chemotaxis, and matrix production by activation of its membrane receptor tyrosine kinase. Because these activities und
Autor:
Charles J Kasiewski, Susan Morgan, Ross G. Bentley, Robert J. Leadley, Mark H Perrone, Jeffery Bostwick, Karen Brown, Dennis Colussi, Dunwiddie Christopher T, Yong Gong, Valeria Chu, Alison Zulli, Kevin Richard Guertin, Jingbo Gao, Pauls Henry W
Publikováno v:
Thrombosis research. 103(4)
FXV673 is a novel, potent, and selective factor Xa (FXa) inhibitor. FXV673 inhibited human, dog, and rabbit FXa with a K(i) of 0.52, 1.41, and 0.27 nM, respectively. FXV673 also displayed excellent specificity toward FXa relative to other serine prot