Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Jeffery B. Press"'
α2 Adrenoceptor Agonists as Potential Analgesic Agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles
Autor:
B Reynolds, Joseph Francis Gardocki, A L Kirifides, Robert E. Boyd, Debra J. Bennett, Jeffery B. Press, Chris Royce Rasmussen, E. E. Codd, Robert B. Raffa, J T Hortenstein, Allen B. Reitz, Charlene D. Connelly
Publikováno v:
Journal of Medicinal Chemistry. 42:5064-5071
A series of (imidazolylmethyl)oxazoles and -thiazoles were prepared and evaluated as alpha(2) adrenoceptor agonists. These compounds were also tested in in vivo paradigms that are predictive of analgesic activity. Variations in both the imidazole and
Publikováno v:
Synthetic Communications. 26:2641-2649
A practical synthetic route to N-Boc protected or Boc-amino acid coupled ω-aminoalkanoic acids is reported and exemplified by the preparation of 8-(t-butoxycarbonylamino)caprylic acid 2 and (N-t-butoxycarbonylphenylalanyl)-8-aminocaprylic acid 3. Th
Publikováno v:
Synthetic Communications. 25:1045-1051
A convenient regiospecific preparation of unsymmetrical α-bromoketones, commencing from Meldrum's acid, has been developed. This procedure allows for preparation of α-bromoketones which are unobtainable in a pure state by other bromination methods
Publikováno v:
Life Sciences. 56:63-74
Autor:
Mary Pat Bonner, Kathleen A. Durkin, Kevin H. Mayo, Dennis C. Liotta, Patricia Keane, Patricia Andrade-Gordon, Hoekstra William J, Jeffery B. Press
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1361-1364
1,3-Adamantanediamine and nipecotic acid were used as scaffolds in designing β-turn peptide mimetic derivatives 3 and 5 , respectively, targeted as fibrinogen-GPIIB/IIIA antagonists. The design focused on the 406–409 KQAG region of the γ-chain of
Autor:
Robert B Raffa, Jeffery B. Press
Publikováno v:
Expert Opinion on Therapeutic Patents. 4:379-393
Publikováno v:
Analgesia. 1:15-25
Publikováno v:
The Journal of Organic Chemistry. 58:4629-4633
Thienopyrans 3, 4, and 5 were synthesized and found to have remarkable differences in stability. Systems 3 and 5 undergo electrocyclic ring-opening to 8 and 18, respectively. In acid milieu at room temperature, system 5 exist in an equilibrium with r
Autor:
Lawrence B. Katz, Jeffery B. Press, James J. McNally, Edward C. Giardino, Robert Falotico, Pauline J. Sanfilippo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1385-1388
The synthesis and antihypertensive activity of novel 7-(subsituted benzamido)-6-hydroxy-5,5- dimethylthieno[3,2-b]pyrans are described. Acetyl substitution on the thiophene significantly increases potency of these benzamides in contrast to the nitro
Autor:
Ramesh M. Kanojia, H. M. Werblood, L. Williams, Robert Falotico, Jeffery B. Press, A. J. Tobia, O. W. Jun. Lever, J. M. Moore
Publikováno v:
ChemInform. 22