Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffery Alan Zablocki"'
Autor:
Joseph C. Loftus, Jeffrey W. Smith, Jeffery Alan Zablocki, Carol Halloran, Larry P. Feigen, Mark H. Ginsberg
Publikováno v:
Journal of Biological Chemistry. 271:2033-2039
The integrin alpha subunits play a major role in the regulation of ligand binding specificity. To gain further insight into the regions of the alpha subunits that regulate ligand specificity, we have utilized alpha v / alpha IIb chimeras to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6450afa0684d02e7d0290907dfa1b049
https://doi.org/10.1074/jbc.271.4.2033
https://doi.org/10.1074/jbc.271.4.2033
Autor:
Jeffery Alan Zablocki, Neal F. Haas, Anita K. Salyers, S.G. Panzer-Knodle, Beatrice B. Taite, Larry P. Feigen, Marc Herin, Kay Broschat, Lucy W. King, Phillipe Jacqmin, Bradley T. Keller, V. Wayne Engleman, Nancy S. Nicholson, James A. Szalony
Publikováno v:
Circulation. 91:403-410
Background Intravenous therapy has been shown to be beneficial in the prevention of acute platelet-associated thrombotic events. However, orally active agents would be advantageous for chronic therapy. Fibrinogen receptor antagonists block the fibrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336714372463ad6d39ffad92b62638ee
https://doi.org/10.1161/01.cir.91.2.403
https://doi.org/10.1161/01.cir.91.2.403
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff7ca1e73492c493b88cb344c8d089
https://doi.org/10.1016/s0968-0896(00)82038-6
https://doi.org/10.1016/s0968-0896(00)82038-6
Publikováno v:
Expert Opinion on Investigational Drugs. 3:437-448
Fibrinogen receptor antagonists represent a potential new form of antithrombotic therapy for the treatment or prevention of vascular complications including: myocardial infarct, unstable angina, stroke and complications during percutaneous translumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed98ef05fd0ed987610c6fdd1530a1e5
https://doi.org/10.1517/13543784.3.5.437
https://doi.org/10.1517/13543784.3.5.437
Autor:
Nancy S. Nicholson, Jeffery Alan Zablocki, R. J. Lindmark, D Pireh, Robert Bruce Garland, Beatrice B. Taite, Masateru Miyano, Shashidhar N. Rao, L Schretzman, S.G. Panzer-Knodle
Publikováno v:
Journal of Medicinal Chemistry. 36:1811-1819
Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in inhibitory potency over the natural RGDF ligand. The guanidine residue of the arginine may be involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418001710ed44efdbaa4f9aa830654d
https://doi.org/10.1021/jm00065a003
https://doi.org/10.1021/jm00065a003
Autor:
Larry P. Feigen, S.G. Panzer-Knodle, P. Jacqmin, V. W. Engleman, J. D. Page, Nancy S. Nicholson, Jeffery Alan Zablocki
Publikováno v:
Platelets. 6(5)
In order to compare binding of small peptide mimetics on activated vs resting platelets and with fibrinogen (fgn) on activated platelets, the binding of [(3)H]-SC-52012, a low molecular weight (483) mimetic of the RGDF sequence present in fgn, was ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d2811bc34d9832d3335c7dc3f49dfc
https://pubmed.ncbi.nlm.nih.gov/21043715
https://pubmed.ncbi.nlm.nih.gov/21043715
Autor:
S. G. Panzer-Knodle, Anita K. Salyers, Jeffery Alan Zablocki, Nancy S. Nicholson, Mihaly V. Toth, F. S. Tjoeng, Beatrice B. Taite, Larry P. Feigen
Publikováno v:
Peptides 1994 ISBN: 9789072199218
Peptides 1994
Peptides 1994
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc4a84a1d002cddfb2f1537c91fdccf
https://doi.org/10.1007/978-94-011-1468-4_327
https://doi.org/10.1007/978-94-011-1468-4_327
Autor:
D. E. Mcmackins, Nancy S. Nicholson, Jeffery Alan Zablocki, Thomas E. Rogers, Mihaly V. Toth, Steven Paul Adams, Beatrice B. Taite, Anita K. Salyers, M. Miyano, M. E. Zupec, R. B. Garland, R. J. Lindmark, F. S. Tjoeng, Larry P. Feigen, P. R. Bovy, J. G. Rico, S G Panzer-Knodle
Publikováno v:
Peptides ISBN: 9789401042956
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad2aa1184fb4053127c0246eabcc23b
https://doi.org/10.1007/978-94-011-0683-2_101
https://doi.org/10.1007/978-94-011-0683-2_101
Autor:
Larry P. Feigen, Nancy S. Nicholson, S.G. Panzer-Knodle, Shashidhar N. Rao, Jeffery Alan Zablocki, Masateru Miyano
Publikováno v:
Journal of medicinal chemistry. 35(26)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67b5e0f4ed6b9111edb46cdf7b4225a
https://pubmed.ncbi.nlm.nih.gov/1479591
https://pubmed.ncbi.nlm.nih.gov/1479591
Publikováno v:
Transfusion Science. 15:iv
Novel substituted β amino acid derivatives are provided which inhibit platelet aggregation and intermediates thereof. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d43257bafebd0048e3431e491d69bed8
https://doi.org/10.1016/0955-3886(94)90077-9
https://doi.org/10.1016/0955-3886(94)90077-9