Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jeffery A Porter"'
Autor:
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Publikováno v:
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://doaj.org/article/740ed0340cbe47708079afcf989db0dd
Autor:
Simone Bonazzi, Eva d’Hennezel, Rohan E.J. Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun C. Bhang, Roxana García Caro, Jennifer S. Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles A. Wartchow, Matthew C. Clifton, Ry R. Forseth, Bethany Hughes Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel M. Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew J. Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine A. Sabatos-Peyton, Natalie A. Dales, Frédéric J. Zécri, Rishi K. Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffery A. Porter, John A. Tallarico, Jeffrey A. Engelman, Glenn Dranoff, James E. Bradner, Michael Visser, Jonathan M. Solomon
Publikováno v:
Cell Chemical Biology. 30:235-247.e12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa86b497ea26c675d8f51551ced46e99
https://doi.org/10.1016/j.chembiol.2023.02.005
https://doi.org/10.1016/j.chembiol.2023.02.005
Autor:
Florian Nigsch, Peter Aspesi, John A. Tallarico, Greg Wendel, Douglas S. Auld, Jeffery A. Porter, Horst Hemmerle, Bushell Simon, Luis Llamas, Gabriel G. Gamber, Labbe-Giguere Nancy, Daniel K. Baeschlin, Maude Patoor, Yuan Wang, Mathias Frederiksen, Felipa A. Mapa, Philip R. Skaanderup, Stephen M. Canham, Jeremy L. Jenkins, Karin Briner, Zhan Deng, Ayako Honda, Rishi K. Jain, Ansgar Schuffenhauer, Allen Cornett, Deborah Rothman, Daniel S. Palacios
Chemogenetic libraries, collections of well-defined chemical probes, provide tremendous value to biomedical research but require substantial effort to ensure diversity as well as quality of the contents. We have assembled a chemogenetic library by da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9142dd606a518f34fda2139182ee13b5
Autor:
D. Randal Kipp, Craig Mickanin, Jeffery A. Porter, Albert Lai, Bing Zheng, Mark Stump, Yan Yan-Neale, John A. Tallarico, Young Shin Cho, Gregory R. Hoffman, Tobias Schmelzle, William R. Sellers, Samuel B. Ho, E. Robert McDonald, Kavitha Venkatesan, Yue Liu, Songping Zhao, Rosalie deBeaumont, Eric Billy, Ying Lin, Francesco Hofmann, Konstantinos J. Mavrakis, Vladimir Capka, Jianjun Yu, Antoine deWeck, Joshua T. McNamara, Emma Lees, Michael R. Schlabach, Hui Gao, Elizabeth R. Sprague, Nicholas Keen, Kristen Hurov, Kenneth Crawford, David A. Ruddy, David N. Ciccone, Guizhi Yang, Fallon Lin, Gregg McAllister, Justin Gu, Raymond Pagliarini, Alberto C. Vitari, Frank Stegmeier, Yingzi Yue, Hong Yin
Publikováno v:
Science. 351:1208-1213
Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities that can be exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90e55c3fe4c3ecfba28cea037cdc9ce
https://doi.org/10.1126/science.aad5944
https://doi.org/10.1126/science.aad5944
Autor:
Owen Wallace, Zhao B. Kang, Jian Ding, Abhishek Dogra, Jeremy L. Jenkins, Joseph Loureiro, Christophe Antczak, Sven Schuierer, John A. Tallarico, Rishi K. Jain, Geoff Boynton, Amy Chen, Scott M. Brittain, Richard I. McDonald, Christy Fryer, Jian Shao, Frederic Sigoillot, Sara Gans, Jeffery A. Porter, Kayla Tyskiewicz, Dominic Hoepfner, Markus Schirle, Erin Nolin, Wilhelm A. Weihofen, Martin Beibel, Jason R. Thomas, Paula Bernasconi-Elias, Elizabeth George, Ning Guo, Guglielmo Roma, Alicia Lindeman, Amy E. Palmer, Yi Yang, Bushell Simon, Luis Llamas, Haibing Guo, Kevin Xie, Stephen M. Canham, Samuel B. Ho, Kyle P. Carter, Nicolette Guthrie, Somnath Bandyopadhyay, John S. Reece-Hoyes
Publikováno v:
Nat Chem Biol
The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations contribute to oncogenic transformation and in targeting the pathway. A phenotypic screen iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf3ead086ac61a242ea003075d48c87
https://pubmed.ncbi.nlm.nih.gov/30643281
https://pubmed.ncbi.nlm.nih.gov/30643281
Autor:
Xiaolu Zhang, Jeffery A. Porter, Atwood K. Cheung, Vic E. Myer, Mark C. Fishman, Caroline Gubser Keller, Rajeev Sivasankaran, John A. Tallarico, Marc Hild, Sven Schuierer, Michael McLellan, Frada Berenshteyn, William F. Dietrich, Cecile Blaustein, Youngah Shin, Lei Shu, Michael Salcius, Monish Jain, Mailin Van Hoosear, Donovan N. Chin, Arnaud Lacoste, Martin Beibel, James Palacino, Nicole A. Renaud, Leo Murphy, Marcel J. J. Blommers, Lawrence G. Hamann, Caroline Bullock, Xiaoying Shi, Lin Deng, Jason R. Thomas, Daniel Curtis, Thomas M. Smith, Susanne E. Swalley, Gregory A. Michaud, Cheng Song, Brian Tseng, Guglielmo Roma, Natalie Dales, Rebecca Servais
Publikováno v:
Nature Chemical Biology. 11:511-517
Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric mortality. A duplicate copy (SMN2) is inefficiently spliced, producing a tru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d75ec4fdc6df87f6744ae079777065c
https://doi.org/10.1038/nchembio.1837
https://doi.org/10.1038/nchembio.1837
Autor:
Stephen B. Helliwell, Ayako Honda, Jane Nagel, Xiaohong Mao, Debra Burdick, Julie Bastien, Henry Wang, Suchithra Menon, Hong Lei, Robert Elling, William E. Dowdle, Dirksen E. Bussiere, Mary Ellen Digan, Lawrence G. Hamann, Ivan Cornella-Taracido, Beat Nyfeler, David Schwalb, Dmitri Wiederschain, Savuth Ugwonali, Fred Harbinski, Markus Schirle, Peter Fekkes, Christine D. Wilson, Shanming Liu, Thomas B. Nicholson, Edmund Harrington, Jason R. Thomas, Reginald Valdez, Vic E. Myer, Brendan D. Manning, Erin P. Keaney, John A. Tallarico, Peter Finan, Mark Labow, Gwynn Pardee, Simon D’Aquin, Andrew F. Powers, John Cantwell, Philip Bergman, Qing Fang, Leon Murphy, Zuncai Wang, Mark Knapp, Jenny Kuerth, Ellen Triantafellow, Catherine Luu, Jeffery A. Porter
Publikováno v:
Nature Cell Biology. 16:1069-1079
Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for autophagy substrates. PIK-III is a selective inhibitor of VPS34 that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2f917aae57e431c829762b739d3143
https://doi.org/10.1038/ncb3053
https://doi.org/10.1038/ncb3053
Autor:
Craig Mickanin, Linda Bagdasarian, Gregory R. Hoffman, Jeffery A. Porter, Kay Xiang, Huili Zhai, Zainab Jagani, Matthew J. Meyer, Frank Buxton, Vic E. Myer, Nadire Ramadan, Rami Rahal, Elizabeth Frias, Charles W. M. Roberts, Janina Huber, Frank Stegmeier, Kristy Haas, Gregory McAllister, Tanushree Phadke, Mariela Jaskelioff, Rodrigo Romero, Veronica Saenz-Vash, Alicia Lindeman, Dongshu Chen, Boris G. Wilson, Margaret E. McLaughlin, Nicholas Keen
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3128-3133
Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic candidates. We therefore set out to systematically interrogate epigenetic cancer dependenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7b9048773c54b470f77944d734533b
https://doi.org/10.1073/pnas.1316793111
https://doi.org/10.1073/pnas.1316793111
Autor:
Jeffery A. Porter, Olga Charlat, Mindy H. Hsieh, Linda Bagdasarian, Monika Avello, Jun Liu, Timothy R. Smith, Yang Xie, Bo Lu, Margaret E. McLaughlin, Huaixiang Hao, Xiaomo Jiang, Joseph D. Growney, Cindy Bottiglio, Ng Nicholas, Steve Woolfenden, Feng Cong, Ronald Meyer, Shifeng Pan
Publikováno v:
Proceedings of the National Academy of Sciences. 110:12649-12654
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However, clinical development of these molecules is challenging because of the lack of a genetic strategy to identify human tumors de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734e3e3206f20017a2553ba56ac59d92
https://doi.org/10.1073/pnas.1307218110
https://doi.org/10.1073/pnas.1307218110
Autor:
Zuncai Wang, Walter Carbone, Jennifer Kelliher, Rowena DeJesus, Guglielmo Roma, John S. Reece-Hoyes, Aylwin Ng, Francesca Moretti, Craig Mickanin, Phil Bergman, Alicia Lindeman, Shanming Liu, Gregory R. Hoffman, John Alford, Martin Beibel, Beat Nyfeler, Leon Murphy, Carsten Russ, John A. Tallarico, Gregory McAllister, Judith Knehr, Ramnik J. Xavier, Elizabeth Frias, Jeffery A. Porter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969d0bf3b951cb089bc956ceb830f70e
https://doi.org/10.7554/elife.17290.014
https://doi.org/10.7554/elife.17290.014