Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jefferson Ray Mccowan"'
Autor:
Jan E. Gillespie, Robert J. Foglesong, Catherine C. Redick, Donetta S. Gifford-Moore, Gerald F. Smith, Daniel Jon Sall, Michael P. Lynch, Mary George Johnson, Jefferson Ray Mccowan, Kyomi Kalter, Duane D. Bronson
Publikováno v:
Tetrahedron. 55:11641-11652
A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de07f03f7797de0d91312b4c62d501f6
https://doi.org/10.1016/s0040-4020(99)00684-5
https://doi.org/10.1016/s0040-4020(99)00684-5
Autor:
Sau-Chi B. Yan, Michael L. Denney, Valentine J. Klimkowski, Amy J. Smith, Lea M. Johnson, Michael Enrico Richett, Minsheng Zhang, Jefferson Ray Mccowan, Kumiko Takeuchi, Todd J. Kohn, Nickolay Y. Chirgadze, Jolie Anne Bastian, Dianna L. Bailey, Donetta S. Gifford-Moore, Barbara G. Utterback, Gerald F. Smith, Daniel Jon Sall, David K. Clawson, Richard Waltz Harper, David W. Snyder, Stephen L. Briggs, Ho-Shen Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:775-780
Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[b]thiophene-based small organic entities 2 and 3 and through SAR additivity studies of the new structural elements identified. X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe7d35a63ca810bf308f9e6a8bf352
https://doi.org/10.1016/s0960-894x(99)00074-8
https://doi.org/10.1016/s0960-894x(99)00074-8
Autor:
Valentine J. Klimkowski, David K. Clawson, Jefferson Ray Mccowan, Daniel Jon Sall, James H. Wikel, Smith Gf, Nickolay Y. Chirgadze, Donetta S. Gifford-Moore, Stephen L. Briggs
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ac3d828c8af680c84a5a1d09806e67
https://doi.org/10.1002/chin.199902106
https://doi.org/10.1002/chin.199902106
Autor:
Todd J. Kohn, Jefferson Ray Mccowan, Kumiko Takeuchi, Smith Gf, Michael L. Denney, Donetta S. Gifford-Moore, Daniel Jon Sall
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee54c1abcc81a50fde052ab190eaef8
https://doi.org/10.1002/chin.199926110
https://doi.org/10.1002/chin.199926110
Autor:
Richard A. Hahn, Robert J. Boyd, William T. Jackson, Terry D. Lindstrom, Lee A. Phebus, Anthony T. Murphy, Alan Breau, Richard D. Towner, Yu Melvin Joseph, G. Donald Pollock, Phillip J. Ertel, Kenneth J. Ruterbories, Mitchell I. Steinberg, Peter P.K. Ho, Jefferson Ray Mccowan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1121-1126
We report a structurally novel series of quinazolines with in vivo antiarrhythmic and/or in vitro iron-dependent lipid peroxidation inhibitory activity. Two analogues, 7 and 12, were evaluated in a canine model of regional myocardial ischemia and rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a5404ca210be1babfacfa1440559c6e
https://doi.org/10.1016/s0960-894x(00)80631-9
https://doi.org/10.1016/s0960-894x(00)80631-9
Autor:
Peter P.K. Ho, Lee A. Phebus, Barbara Bertsch, Paul J. Simpson, Kenneth J. Ruterbories, Terry D. Lindstrom, Jefferson Ray Mccowan, Yu Melvin Joseph, Jeffrey K. Smallwood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:59-62
A series of phenothiazine and phenoxazine analogs of nafazatrom were prepared and evaluated as 5-lipoxygenase and iron-dependent lipid peroxidation inhibitors (rabbit brain homogenate) in vitro. Nafazatrom and two representatives from the described s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32697d2217eee6990bcdcb00fbb70444
https://doi.org/10.1016/s0960-894x(00)80655-1
https://doi.org/10.1016/s0960-894x(00)80655-1
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:107-110
A series of phenoxazines was evaluated as in vitro inhibitors of 5-lipoxygenase (5-LO) and iron-dependent lipid peroxidation. A linear relationship (r2 = 0.91, n = 10) was found for the ester, hydroxamic acid and C-1 carboxylic acid representatives s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0522b460d51d68fe6f24427c1ea7eb00
https://doi.org/10.1016/s0960-894x(00)80241-3
https://doi.org/10.1016/s0960-894x(00)80241-3
Publikováno v:
Drug Development Research. 23:237-252
Prazosin stimulated 125l-rANP(102–126) binding to bovine adrenal zona glomerulosa membranes (BAZGM) allosterically by converting the lower-affinity state binding sites into the higher-affinity state. The modulatory effect could be mimicked by guana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c4df357d7713a7b5075112043942b6
https://doi.org/10.1002/ddr.430230306
https://doi.org/10.1002/ddr.430230306
Autor:
Jeffrey T. Mullaney, Matthew J. Fisher, Suzane L. Um, Terry D. Lindstrom, Michael Paal, Joseph A. Jakubowski, Ulrich Giese, Michael Dean Kinnick, Theo Schotten, Robert M. Scarborough, Ken J. Ruterbories, John Michael Morin, Virginia L. Wyss, Richard D. Towner, Gerd Ruhter, Jefferson Ray Mccowan, Achim Rapp, Wolfgang Stenzel, Hans-Jürgen Mest, Cathy S. Harms, Daniel Jon Sall, Barbara G. Utterback
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(4)
6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement with a heteroaryl amidine was tolerated in this series. Use of an acyl-linked 4-alkyl piperi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708f4b432facf3a7b5ee1420ba768d94
https://pubmed.ncbi.nlm.nih.gov/10714506
https://pubmed.ncbi.nlm.nih.gov/10714506
Autor:
Gerald F. Smith, Matthew J. Fisher, John E. Toth, Nickolay Y. Chirgadze, Deborah D. Giera, Dianna L. Bailey, John A. Buben, Amy Clemens-Smith, Michael L. Denney, Michael Enrico Richett, Richard Waltz Harper, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Valentine J. Klimkowski, Todd J. Kohn, Jefferson Ray Mccowan, Kumiko Takeuchi, Ho-Shen Lin, Daniel Jon Sall, Donetta S. Gifford-Moore, Lea M. Johnson, David W. Snyder
Publikováno v:
Journal of medicinal chemistry. 43(4)
A systematic investigation of the structure-activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent thrombin inhibitors 23c, 28c, and 31c. Their activities (1240, 903, and 1271 x 10(6) L/mol, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b65bb93c4bac89d1ca25c10915de94
https://pubmed.ncbi.nlm.nih.gov/10691691
https://pubmed.ncbi.nlm.nih.gov/10691691