Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jefferson Foote"'
Autor:
J. Paul Banga, Jefferson Foote, Carolyn J. Padoa, Christiane S. Hampe, Eva Örtqvist, T. R. Hall, Marinos C. Dalakas, Raghavanpillai Raju
Publikováno v:
The Journal of Immunology. 175:7755-7762
Autoantibodies to the 65-kDa isoform of glutamate decarboxylase GAD65 (GAD65Ab) are strong candidates for a pathological role in Stiff-Person syndrome (SPS). We have analyzed the binding specificity of the GAD65Ab in serum and cerebrospinal fluid (CS
Autor:
David A. Mitchell, Jefferson Foote, Timothy N. Buss, Philip Tan, Margaret A. Holmes, Claudio Anasetti
Publikováno v:
The Journal of Immunology. 169:1119-1125
Humanized Abs are created by combining, at the genetic level, the complementarity-determining regions of a murine mAb with the framework sequences of a human Ab variable domain. This leads to a functional Ab with reduced immunogenic side effects in h
Publikováno v:
The Journal of Immunology. 167:296-301
A humanized version of the mouse anti-lysozyme Ab D1.3 was previously constructed as an Fv fragment and its structure was crystallographically determined in the free form and in complex with lysozyme. Here we report five new crystal structures of sin
Publikováno v:
The Journal of Experimental Medicine
The crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-Å resolution. The structure of the antigen combining site in the complex is nearly identical to that of the
Autor:
Jefferson Foote, Greg Winter
Publikováno v:
Journal of Molecular Biology. 224:487-499
Rodent monoclonal antibodies have been "humanized" or "reshaped" for therapy by transplanting the antigen-binding loops from their variable domains onto the beta-sheet framework regions of human antibodies. However, additional substitutions in the hu
Autor:
Jefferson Foote, Carol O’Hear
Publikováno v:
European journal of haematology. 84(3)
Objective: To assess the ability of an anti-lysozyme antibody to stabilize the plasma pharmacokinetics of lysozyme through a 'buffering' effect. Methods: Hen egg lysozyme was radiolabeled with 14 C and infused with or without the murine anti-lysozyme
Autor:
Carol Elaine O'hear, Jefferson Foote
Publikováno v:
Journal of molecular biology. 364(5)
The efficacy of chemotherapy on brain tumors is often hindered by the presence of the blood brain barrier. This barrier keeps many systemically administered substances from entering the cerebrospinal fluid (CSF), while allowing intrathecally administ
Autor:
Federico Fogolari, Laura Ragona, Jefferson Foote, Maddalena Catalano, Henriette Molinari, Marianna Luppi, Daniel O. Cicero, Tommaso Eliseo, Lucia Zetta
Publikováno v:
The Journal of biological chemistry
281 (2006): 9697–9709. doi:10.1074/jbc.M513003200
info:cnr-pdr/source/autori:Ragona L; Catalano M; Luppi M; Cicero D; Eliseo T; Foote J; Fogolari F; Zetta L; Molinari H/titolo:NMR dynamic studies suggest that allosteric activation regulates ligand binding in chicken liver bile acid-binding protein/doi:10.1074%2Fjbc.M513003200/rivista:The Journal of biological chemistry (Print)/anno:2006/pagina_da:9697/pagina_a:9709/intervallo_pagine:9697–9709/volume:281
281 (2006): 9697–9709. doi:10.1074/jbc.M513003200
info:cnr-pdr/source/autori:Ragona L; Catalano M; Luppi M; Cicero D; Eliseo T; Foote J; Fogolari F; Zetta L; Molinari H/titolo:NMR dynamic studies suggest that allosteric activation regulates ligand binding in chicken liver bile acid-binding protein/doi:10.1074%2Fjbc.M513003200/rivista:The Journal of biological chemistry (Print)/anno:2006/pagina_da:9697/pagina_a:9709/intervallo_pagine:9697–9709/volume:281
Apo chicken liver bile acid-binding protein has been structurally characterized by NMR. The dynamic behavior of the protein in its apo- and holo-forms, complexed with chenodeoxycholate, has been determined via (15)N relaxation and steady state hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6827e60b86f193c3733141a011e6b8bd
http://www.cnr.it/prodotto/i/54290
http://www.cnr.it/prodotto/i/54290
Autor:
Jefferson Foote, Carol Elaine O'hear
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(1)
Clearance is the practical limit on drug action. Here we propose a means of slowing clearance, thereby extending drug lifetimein vivoby “antibody buffering.” In this process, a drug and an anti-drug antibody are coadministered. Most of the drug i
Autor:
Jefferson Foote, William Hwang
Publikováno v:
Methods (San Diego, Calif.). 36(1)
Administration of a therapeutic antibody can lead to an anti-antibody response (AAR). Much effort has been applied to engineering antibodies with as little as possible non-human structure to minimize such responses. Here, we review reported AAR to mu