Výsledky vyhledávání - "Jefferson Chin"

Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging

Autor: Neha Surti, Jonathan Lippy, Samuel Gerritz, David G. Harden, Peter Chase, Jefferson Chin, Julia M. Nielsen, Harold N. Weller, R. Michael Lawrence, Wilson Z. Shou, Darshani Weerakoon

Publikováno v: SLAS discovery : advancing life sciences RD. 26(2)

Hits from high-throughput screening (HTS) assays are typically evaluated using cheminformatics and/or empirical approaches before a decision for follow-up (activity confirmation and/or sample resynthesis) is made. However, the compound integrity (i.e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c60028ac212de1108d34666138b183b
https://pubmed.ncbi.nlm.nih.gov/32400264

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Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-Throughput Screening

Autor: Martyn Banks, Ashley M. Hine, Caitlin E. Scott, Jefferson Chin, Litao Zhang, Mike Power, Yu-Hsien Liao, Lisa M. Ogawa, Samuel Gerritz, Edward J. Hunnicutt, Craig J. Dowling, Debra A. Kendall, Neil T. Burford, Andrew Alt, Victoria L. Emerick

Publikováno v: SLAS Discovery. 23:375-383

The endocannabinoid system (ECS) plays a diverse role in human physiology ranging from the regulation of mood and appetite to immune modulation and the response to pain. Drug development that targets the cannabinoid receptors (CB(1) and CB(2)) has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b06cf8c35b129d5cdbd5b9ad655341
https://doi.org/10.1177/2472555217748403

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Acoustic Sample Deposition MALDI-MS (ASD-MALDI-MS): A Novel Process Flow for Quality Control Screening of Compound Libraries

Autor: Elizabeth Wood, Dieter M. Drexler, Jefferson Chin, Grace S. Peters

Publikováno v: SLAS Technology. 21:204-207

In the early stages of drug discovery, high-throughput screening (HTS) of compound libraries against pharmaceutical targets is a common method to identify potential lead molecules. For these HTS campaigns to be efficient and successful, continuous qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc869b825bb1cf76a0393572618ab8a
https://doi.org/10.1177/2211068215594769

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SPEEDY: Spin−Echo Enhanced Diffusion Filtered Spectroscopy. A New Tool for High Resolution MAS NMR

Autor: Jefferson Chin, and Aidi Chen, Michael J. Shapiro

Publikováno v: Journal of Combinatorial Chemistry. 2:293-296

The pulsed field gradient diffusion edited experiment, bipolar LED, has been combined with the Carr-Purcell-Meiboom-Gill (CPMG) spin-echo sequence for the analysis of solid phase resin samples. Spin-echo enhanced diffusion filtered spectroscopy (SPEE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0982a83df93c068c0b7faeca66d432
https://doi.org/10.1021/cc0000038

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Synthesis of Isodehydroilludin M

Autor: Jefferson Chin, Frederick Ray Kinder, Michael J. Shapiro, Kenneth W. Bair

Publikováno v: Synthetic Communications. 28:2541-2548

Isodehydroilludin M was synthesized from carbonyl ylid 1,3-dipolar cycloaddition product that was further elaborated with an unusual PCC-mediated double oxidation reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0535778fee766df96ba2800ddbe25cf
https://doi.org/10.1080/00397919808004305

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HPLC/NMR in Combinatorial Chemistry

Autor: Fell Jay Bradford, Mark A. Jarosinski, Jefferson Chin, James R. Wareing, Michael J. Shapiro

Publikováno v: The Journal of Organic Chemistry. 63:386-390

When sufficient material is available, NMR spectroscopy is unsurpassed for detailed structure determination in solution. However, the application of NMR to the determination of structure in multicomponent organic chemical systems prior to physical se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f7eb11a25fd803b665836d0a416ce8a
https://doi.org/10.1021/jo9713666

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In Vitro Metabolism of N-(5-Chloro-2-methylphenyl)-N‘-(2-methylpropyl)thiourea: Species Comparison and Identification of a Novel Thiocarbamide−Glutathione Adduct

Autor: K. Hitchcock, Michael J. Shapiro, G. M. Coppola, Y. K. Wang, Jefferson Chin, G. J. Stevens, S. Suwanrumpha, B. L. K. Mangold, R. W. Versace

Publikováno v: Chemical Research in Toxicology. 10:733-741

The in vitro metabolism of SDZ HDL 376, a thiocarbamide developed for the treatment of atherosclerosis, was investigated in rat, dog, monkey, and human liver microsomes, as well as in rat and human liver slices. [14C]SDZ HDL 376 was extensively metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94671db215c804e9c3278778e1798ba6
https://doi.org/10.1021/tx9700230

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Synthesis of optically active 6-substituted 2-(aminomethyl)chromans

Autor: Gaetan H. Ladouceur, Bullock William H, Cheng Bi, Mingbao Zhang, Jefferson Chin, Robert Dally, Raymond Reeves

Publikováno v: Tetrahedron Letters. 45:5229-5231

Three novel, optically active, 6-substituted 2-(aminomethyl)chromans were synthesized from readily available chroman 2-carboxylic acid precursors. These chroman-containing primary amines are useful building blocks for the synthesis of chroman-derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5b63668c620cbb61dfefbdc3a57998
https://doi.org/10.1016/j.tetlet.2004.05.037

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