Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Autor: Horby, Peter W, Mafham, Marion, Bell, Jennifer L, Linsell, Louise, Staplin, Natalie, Emberson, Jonathan, Palfreeman, Adrian, Raw, Jason, Elmahi, Einas, Prudon, Benjamin, Green, Christopher, Carley, Simon, Chadwick, David, Davies, Matthew, Wise, Matthew P, Baillie, J Kenneth, Chappell, Lucy C, Faust, Saul N, Jaki, Thomas, Jefferey, Katie, Lim, Wei Shen, Montgomery, Alan, Rowan, Kathryn, Juszczak, Edmund, Haynes, Richard, Landray, Martin J, The Recovery Collaborative Group

SummaryBackground Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity,preclinical studies, and observational studies. Here, we report the results of a randomised trial to assess whether lopinavir–ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::753a1f76e72e1a8fea538fa408ca1013

Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel.

Autor: Adams ER; Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK., Ainsworth M; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Anand R; NHS Blood and Transplant Birmingham, Vincent Drive, Birmingham, B15 2SG, UK., Andersson MI; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Auckland K; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Baillie JK; Roslin Institute, University of Edinburgh, Edinburgh, EH25 9RJ, UK., Barnes E; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Beer S; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Bell JI; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Berry T; Department of Health and Social Care, UK Government, London, UK., Bibi S; Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, OX3 7LE, UK., Carroll M; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK.; Public Health England, Porton Down, Salisbury, SP4 0JG, UK., Chinnakannan SK; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Clutterbuck E; Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, OX3 7LE, UK., Cornall RJ; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Crook DW; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., de Silva T; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Dejnirattisai W; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Dingle KE; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Dold C; Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, OX3 7LE, UK., Espinosa A; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Eyre DW; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Farmer H; Department of Health and Social Care, UK Government, London, UK., Fernandez Mendoza M; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Georgiou D; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Hoosdally SJ; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Hunter A; NHS Blood and Transplant Basildon, Burnt Mills Industrial Estate, Basildon, SS13 1FH, UK., Jefferey K; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Kelly DF; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, OX3 7LE, UK., Klenerman P; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Knight J; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Knowles C; Department of Health and Social Care, UK Government, London, UK., Kwok AJ; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Leuschner U; NHS Blood and Transplant Oxford, John Radcliffe Hospital, Oxford, UK., Levin R; Worthing Hospital, Worthing, BN11 2DH, UK., Liu C; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., López-Camacho C; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Martinez J; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Matthews PC; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., McGivern H; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK., Mentzer AJ; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Milton J; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK., Mongkolsapaya J; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Moore SC; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK., Oliveira MS; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK., Pereira F; Imperial College London, London, SW7 2AZ, UK., Perez E; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Peto T; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Ploeg RJ; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK., Pollard A; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, OX3 7LE, UK., Prince T; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK., Roberts DJ; NHS Blood and Transplant Oxford, John Radcliffe Hospital, Oxford, UK., Rudkin JK; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Sanchez V; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Screaton GR; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Semple MG; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.; Alder Hey Children's Hospital, Liverpool, UK., Slon-Campos J; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Skelly DT; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., Smith EN; Department of Health and Social Care, UK Government, London, UK., Sobrinodiaz A; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Staves J; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Stuart DI; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 ODE, UK., Supasa P; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Surik T; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK., Thraves H; Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK., Tsang P; NHS Blood and Transplant Oxford, John Radcliffe Hospital, Oxford, UK., Turtle L; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.; Tropical & Infectious Disease Unit, Royal Liverpool University Hospital (member of Liverpool Health Partners), Liverpool, L7 8XP, UK., Walker AS; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Wang B; Nuffield Department of Medicine and NIHR Oxford Biomedical Research Centre,, University of Oxford, Oxford, OX3 9DU, UK., Washington C; NHS Blood and Transplant Birmingham, Vincent Drive, Birmingham, B15 2SG, UK., Watkins N; NHS Blood and Transplant Cambridge, Long Road, Cambridge, CB2 0PT, UK., Whitehouse J; Department of Health and Social Care, UK Government, London, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2020 Jun 11; Vol. 5, pp. 139. Date of Electronic Publication: 2020 Jun 11 (Print Publication: 2020).