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A phase 1/2 open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of OTX-2002 as a single agent and in combination with standard of care in patients with hepatocellular carcinoma and other solid tumor types known for association with the MYC oncogene (MYCHELANGELO I)

Autor: Ildefonso I Rodriguez-Rivera, Ting-Hui Wu, Rachel Ciotti, William Senapedis, Kaitlyn Sullivan, Jeff Z Gao, Sangeetha Palakurthi, Thomas McCauley, Yan Moore

Publikováno v: Journal of Clinical Oncology. 41:TPS627-TPS627

TPS627 Background: MYC, or c-MYC, is a master regulator of gene expression that controls cell growth and proliferation. Dysregulation of MYC is frequently identified in various cancer types, including hepatocellular carcinoma (HCC), where it is overe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99d5849a17b999e63d14ab96b4994b50
https://doi.org/10.1200/jco.2023.41.4_suppl.tps627

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