Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jeff Y.K. Tom"'
Autor:
Rami N. Hannoush, Karen Stanger, Lijuan Zhou, Christine Tam, Yingnan Zhang, Irina N. Krylova, Clifford Quan, Micah Steffek, Christine Pozniak, Joseph W. Lewcock, J. Michael Elliott, Yvonne Franke, Jeremy Murray, Jeff Y.K. Tom
Publikováno v:
Nature Chemical Biology. 8:655-660
The caspases are a family of cytosolic proteases with essential roles in inflammation and apoptosis. Drug discovery efforts have focused on developing molecules directed against the active sites of caspases, but this approach has proved challenging a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3807c628237d08016f0435deb077ebdb
https://doi.org/10.1038/nchembio.967
https://doi.org/10.1038/nchembio.967
Publikováno v:
Molecular and Cellular Biochemistry. 178:317-324
Systemic clearance of atrial natriuretic peptide (ANP) is in part due to neutral endopeptidase (NEP) proteolysis and natriuretic peptide receptor-C (NPR-C) mediated endocytosis. Biological responses to ANP are primarily mediated by the membrane guany
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f033b1485f342f384fc33d0d5001ce
https://doi.org/10.1023/a:1006823732336
https://doi.org/10.1023/a:1006823732336
Publikováno v:
FEBS Letters. 414:263-267
Libraries of monovalent display-phage expressing mutant human B-type natriuretic peptide (hBNP) were used to identify variants that preferentially bind natriuretic peptide receptor-A (NPR-A) compared to receptor-C (NPR-C). Position 19 was a significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817143c29fc2bd9dfd6a7027382fd241
https://doi.org/10.1016/s0014-5793(97)00956-3
https://doi.org/10.1016/s0014-5793(97)00956-3
Erratum: Corrigendum: Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
Autor:
Yvonne Franke, Karen Stanger, Jeremy Murray, Christine Pozniak, Lijuan Zhou, Joseph W. Lewcock, Rami N. Hannoush, J. Michael Elliott, Clifford Quan, Christine Tam, Micah Steffek, Yingnan Zhang, Jeff Y.K. Tom
Publikováno v:
Nature Chemical Biology. 9:466-466
Nat. Chem. Biol. 8, 655–660 (2012); published online 10 June 2012; corrected after print 21 May 2013 In the version of this article initially published, Irina Krylova was inadvertently acknowledged rather than included in the author list. The autho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::935a12825a974fc62dac51ea60882f68
https://doi.org/10.1038/nchembio-0613-466b
https://doi.org/10.1038/nchembio-0613-466b
Autor:
Bing Li, Wayne J. Fairbrother, James A. Wells, Brian C. Cunningham, Jeff Y.K. Tom, Randy Yen, David Oare
Publikováno v:
Science (New York, N.Y.). 270(5242)
A stepwise approach for reducing the size of a polypeptide hormone, atrial natriuretic peptide (ANP), from 28 residues to 15 while retaining high biopotency is described. Systematic structural and functional analysis identified a discontinuous functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c847c5968564eaf3a24ff6d68017b6a5
https://pubmed.ncbi.nlm.nih.gov/7502074
https://pubmed.ncbi.nlm.nih.gov/7502074
Autor:
John P. Bumier, Robert S. McDowell, Kenneth J. Paris, Stanley Mark S, Todd C. Somers, Yingchun Xue, Thomas E. Rawson, Dairian T. Wan, Jeff Y.K. Tom, James C. Marsters, David Oare, Daniel J. Burdick, Martin E. Struble, Charles M. Duarte, Mark Reynolds, Kathryn S. Chan
Publikováno v:
Bioorganicmedicinal chemistry. 2(9)
A structural survey of protein Zn 2+ binding geometries was instigated based upon the functional requirement of Ras farnesyltransferase for Zn 2+ . The Cys-X-X-Cys motif found in Zn 2+ -binding proteins such as aspartate transcarbamylase was used as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb07591e765fcb379ea79604317179b
https://pubmed.ncbi.nlm.nih.gov/7712130
https://pubmed.ncbi.nlm.nih.gov/7712130