Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jeff Y. F. Wong"'
Publikováno v:
Chemical Science
Tetrazoles play a prominent role in medicinal chemistry due to their role as carboxylate bioisosteres but have largely been overlooked as C–H functionalisation substrates. We herein report the development of a high-yielding and general procedure fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83330de405c75bb4da08be644572fbf
https://doi.org/10.1039/d1sc04176b
https://doi.org/10.1039/d1sc04176b
Publikováno v:
Chemistry – A European Journal. 25:12439-12445
1,3,4-Oxadiazoles are a common motif in pharmaceutical chemistry, but few convenient methods for their modification exist. A fast, convenient, high yielding and general α-substitution of 1,3,4-oxadiazoles has been developed using a metalation-electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8440b93238c69f9e02b17c582c26f057
https://doi.org/10.1002/chem.201902917
https://doi.org/10.1002/chem.201902917
Publikováno v:
Organic Letters. 21:7069-7072
1H-Tetrazoles occupy an important role in modern medicinal chemistry, but few methods for their modification exist. Many extant protocols require the use of a difficult to remove N-alkyl-protecting group, precluding the products from use as carboxyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c355a4da9366656ca9b57dd46245398
https://doi.org/10.1021/acs.orglett.9b02633
https://doi.org/10.1021/acs.orglett.9b02633
Autor:
Graeme Barker, Jeff Y. F. Wong
Publikováno v:
Tetrahedron. 76:131704
Aryl and heteroaryl rings are omnipresent in small molecule drugs, and examples bearing multiple substitutions at benzylic positions are ubiquitous across a range of pharmaceutical families. The comparative acidity of α-aryl protons makes organolith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c9ae8e196a075b5d68367ab8254ef26
https://doi.org/10.1016/j.tet.2020.131704
https://doi.org/10.1016/j.tet.2020.131704