Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jeff Wickens"'
Autor:
Gail Tripp, Jeff Wickens
Publikováno v:
Personality Neuroscience, Vol 7 (2024)
An altered behavioral response to positive reinforcement has been proposed to be a core deficit in attention deficit hyperactivity disorder (ADHD). The spontaneously hypertensive rat (SHR), a congenic animal strain, displays a similarly altered respo
Externí odkaz:
https://doaj.org/article/440faacda2d14fa0b5cc9322ec558732
Autor:
Adam Ponzi, Jeff Wickens
Publikováno v:
Frontiers in Computational Neuroscience, Vol 16 (2022)
Control of the timing of behavior is thought to require the basal ganglia (BG) and BG pathologies impair performance in timing tasks. Temporal interval discrimination depends on the ramping activity of medium spiny neurons (MSN) in the main BG input
Externí odkaz:
https://doaj.org/article/de4095f85aa5468bb9cd486a185e0ecf
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Adeno-associated viral (AAV) vectors, used as vehicles for gene transfer into the brain, are a versatile and powerful tool of modern neuroscience that allow identifying specific neuronal populations, monitoring and modulating their activity. For cons
Externí odkaz:
https://doaj.org/article/929b174d658a488aba05af84669ab049
Autor:
Masakazu Igarashi, Jeff Wickens
Publikováno v:
Journal of Neurophysiology. 121(2):490-499
Bimanual coordination, in which both hands work together to achieve a goal, is crucial for the basic needs of life, such as gathering and feeding. Such coordinated motor skill is highly developed in primates, where it has been most extensively studie
Autor:
Paulo Mattos, Myriam Monteiro, Jorge Moll, Emi Furukawa, Patricia Bado, Jeff Wickens, Sebastian Hoefle, Raquel Quimas Molina da Costa, Gail Tripp, Paula Vigne
Publikováno v:
Neuropharmacology. 162:107833
Attention deficit hyperactivity disorder (ADHD) has been associated with neural hyposensitivity to reward-predicting cues. Methylphenidate is widely used in the management of the disorder's symptoms, but its effects on reward sensitivity in ADHD are
Publikováno v:
The European journal of neuroscience. 47(10)
Autor:
Gail Tripp, Jeff Wickens
Publikováno v:
Neurotherapeutics
Attention deficit hyperactivity disorder (ADHD) presents special challenges for drug development. Current treatment with psychostimulants and nonstimulants is effective, but their mechanism of action beyond the cellular level is incompletely understo
Autor:
John N. J. Reynolds, Koreen M. Clements, Ad Aertsen, Carsten Mehring, Peter Redgrave, Jan M. Schulz, Jeff Wickens
Publikováno v:
The Journal of Neuroscience. 29:6336-6347
The striatum is a site of integration of neural pathways involved in reinforcement learning. Traditionally, inputs from cerebral cortex are thought to be reinforced by dopaminergic afferents signaling the occurrence of biologically salient sensory ev
Publikováno v:
Neurotransmitter.
Neurotransmission is a key process for communication between neurons. Mimicking neurotransmitter release with precise control in timing and dosage would provide a powerful tool to investigate brain functions and mechanisms. We developed a novel metho
Publikováno v:
The Journal of Neuroscience. 24:9870-9877
Striatal cholinergic interneurons, also known as tonically active neurons (TANs), acquire a pause in firing during learning of stimulus-reward associations. This pause response to a sensory stimulus emerges after repeated pairing with a reward. The c