Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jeff Wallin"'
Autor:
Nicole Blaquiere, Cristina Lewis, Ping Wu, Steven T. Staben, Jeremy Murray, Aleks Kolesnikov, Robert Heald, Richard James Bull, Leslie Lee, Jones Mark, Lan Wang, Timothy P. Heffron, Jeff Wallin, Christian Weismann, Jodie Pang, Binqing Wei, Graham Elgin Jones, Wei Wei Prior, Alan G. Olivero, Daniel C. Gray, Rachel Ord, Kyle A. Edgar, Jim Nonomiya, Danette Dudley, Deepak Sampath, Neville James Mclean, Marcia Belvin, Laurent Salphati, Chudi Ndubaku, Stephen Price, Lionel Rouge, John Lesnick
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(9)
A series of suitable five-membered heterocyclic alternatives to thiophenes within a thienobenzoxepin class of PI3-kinase (PI3K) inhibitors was discovered. Specific thiazolobenzoxepin 8-substitution was identified that increased selectivity over PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5724e89337ad63dc70f387ab6026b1e7
https://pubmed.ncbi.nlm.nih.gov/23540645
https://pubmed.ncbi.nlm.nih.gov/23540645
Autor:
Neil Anthony Pegg, Jim Nonomiya, Jerry Hsu, Neville James Mclean, Richard Goldsmith, Graham B. Jones, Jodie Pang, Marcia Belvin, Wei Wei Prior, Tony Gianetti, Georgette Castanedo, Robert Heald, Ross Francis, Jeremy Murray, Nicole Blaquiere, Steven T. Staben, Xiaolin Zhang, Mika K. Derynck, Aleks Kolesnikov, Alan G. Olivero, Jane Guan, Mark R. Lackner, Deepack Sampath, Jeff Wallin, Erin K. Bradley, Phillip Jackson, Steven Do, Michael Siu, Timothy P. Heffron, Stephen Sideris, Matthew Baumgardner, Michael Mamounas, Leanne Ross, Paul Goldsmith, Danette Dudley, Leslie Lee, Kyle A. Edgar, Mark Ultsch, Trevor Keith Harrison, Chudi Ndubaku, Jennafer Dotson, Adrian Folkes, Lan Wang, Laurent Salphati, John Lesnick, Cristina Lewis, Amy Kim, Christian Wiesmann, Lori Friedman, Daniel P. Sutherlin
Publikováno v:
Cancer Research. 73:DDT02-01
Modifications of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway are frequent in cancer due to multiple mechanisms, including activating mutations of the alpha isoform of PI3K. The dysregulation of this pathway has been implicated in many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8bf145f748f507d32e199857faa73cb
https://doi.org/10.1158/1538-7445.am2013-ddt02-01
https://doi.org/10.1158/1538-7445.am2013-ddt02-01
Autor:
Binqing Wei, Tim Heffron, Georgette Castanedo, Leanne Berry, Laurent Salphati, Jim Nonomiya, Cristina Lewis, Jeff Wallin, Wei Wei Prior, James C. Marsters, Deepak Sampath, Kyle A. Edgar, Megan Berry, Adrian Folkes, Sonal Patel, Marcia Belvin, Alan G. Olivero, Vickie Tsui, Linda Bao, Daniel P. Sutherlin, John Lesnick, Lori Friedman, Jodie Pang, Bing-Yan Zhu, Christian Weismann
Publikováno v:
Cancer Research. 71:2787-2787
PI3 Kinase and mTOR have been identified as promising targets for the treatment of cancer. These enzymes participate in related, but not redundant, signaling networks to transmit cellular growth and survival signals, which are hallmarks of tumor grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ce6d28e3741ec52e1230abee092263
https://doi.org/10.1158/1538-7445.am2011-2787
https://doi.org/10.1158/1538-7445.am2011-2787
Autor:
Bing-Yan Zhu, Laurent Salphati, Lori Friedman, Georgette Castanedo, Wei Wei Prior, Adrian Folkes, Sonal Patel, Cris Lewis, Deepak Sampath, Leanne Berry, Jane Guan, Alan G. Olivero, Tim Heffron, Jeff Wallin, Dan Sutherlin, Jim Nonomiya, Megan Berry, Marcia Belvin, Jodie Pang, Kyle A. Edgar, John Lesnick
Publikováno v:
Molecular Cancer Therapeutics. 8:C201-C201
Introduction: The phosphoinositide-3 kinase (PI3K)/Akt signaling pathway is deregulated in a wide variety of cancers. Somatic activating mutations and amplifications in PI3K are common in multiple cancers including breast, colon, and lung cancer. PTE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728077807bb3b66a217c31c343e38cfa
https://doi.org/10.1158/1535-7163.targ-09-c201
https://doi.org/10.1158/1535-7163.targ-09-c201