Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeff W Cramer"'
Autor:
Rongjun He, Jifeng Wang, Zhi-Hong Yu, Julie S. Moyers, M. Dodson Michael, Timothy B. Durham, Jeff W. Cramer, Yuewei Qian, Amy Lin, Li Wu, Nicholas Noinaj, David G. Barrett, Zhong-Yin Zhang
Publikováno v:
J Med Chem
Protein tyrosine phosphatases constitute an important class of drug targets, whose potential has been limited by the paucity of drug-like small molecule inhibitors. We recently described a class of active site-directed, moderately selective and poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c61119301642263decda2d2789be67b
https://doi.org/10.1021/acs.jmedchem.2c01143
https://doi.org/10.1021/acs.jmedchem.2c01143
Autor:
Robert J. Konrad, Jessie L. Bishop, Kristin Hollister, Nicoletta Bivi, Margaret A Gardner, Jeff W. Cramer, Michael E Hodsdon, Huy T Nguyen
Publikováno v:
Bioanalysis. 12:1597-1605
Over the developmental lifetime of a therapeutic protein, the immunogenicity assay validation history can become substantial, frustrating review of clinical immunogenicity within the biologics license application. In our experience, this can lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678477f8007439f8756cf9e3e5c9f9c6
https://doi.org/10.4155/bio-2020-0234
https://doi.org/10.4155/bio-2020-0234
Autor:
Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
Publikováno v:
Journal of Medicinal Chemistry. 62:8711-8732
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a353395d3c6f7ca6dfa78c95a347dd4
https://doi.org/10.1021/acs.jmedchem.9b01234
https://doi.org/10.1021/acs.jmedchem.9b01234
Autor:
Junliang, Hao, James P, Beck, John M, Schaus, Joseph H, Krushinski, Qi, Chen, Christopher D, Beadle, Paloma, Vidal, Matthew R, Reinhard, Bruce A, Dressman, Steven M, Massey, Serge L, Boulet, Michael P, Cohen, Brian M, Watson, David, Tupper, Kevin M, Gardinier, Jason, Myers, Anette M, Johansson, Jeffery, Richardson, Daniel S, Richards, Erik J, Hembre, David M, Remick, David A, Coates, Rajni M, Bhardwaj, Benjamin A, Diseroad, David, Bender, Greg, Stephenson, Craig D, Wolfangel, Nuria, Diaz, Brian G, Getman, Xu-Shan, Wang, Beverly A, Heinz, Jeff W, Cramer, Xin, Zhou, Deanna L, Maren, Julie F, Falcone, Rebecca A, Wright, Stephen N, Mitchell, Guy, Carter, Charles R, Yang, Robert F, Bruns, Kjell A, Svensson
Publikováno v:
Journal of medicinal chemistry. 62(19)
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38771cd6f379be26a1a0dc76826df19b
https://pubmed.ncbi.nlm.nih.gov/31532644
https://pubmed.ncbi.nlm.nih.gov/31532644
Autor:
David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou
Publikováno v:
Drug Metabolism and Disposition. 44:1184-1192
The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic changes resemble human type 2 diabetes associated with obesity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e69d23677d8c4507f2e53434027c9b
https://doi.org/10.1124/dmd.116.070623
https://doi.org/10.1124/dmd.116.070623
Autor:
Maria Angeles, Martinez-Grau, Isabel C Gonzalez, Valcarcel, Julie V, Early, Richard Klaus, Gessner, Candice Soares, de Melo, Eva Maria Martin, de la Nava, Aaron, Korkegian, Yulia, Ovechkina, Lindsay, Flint, Anisa, Gravelle, Jeff W, Cramer, Prashant V, Desai, Leslie J, Street, Joshua, Odingo, Thierry, Masquelin, Kelly, Chibale, Tanya, Parish
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Highlights • We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis. • Improved compounds have sub-micromolar butyrate-specific activity. • Compounds are not cytot
Highlights • We conducted SAR for the aryl-oxadiazole series with anti-bacterial activity against Mycobacterium tuberculosis. • Improved compounds have sub-micromolar butyrate-specific activity. • Compounds are not cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1742c0d1b5dfb73d21a014effa96602e
https://pubmed.ncbi.nlm.nih.gov/29680666
https://pubmed.ncbi.nlm.nih.gov/29680666
Publikováno v:
Pharmacology Biochemistry and Behavior. 112:1-8
Serotonin acts through receptors controlling several physiological functions, including energy homeostasis regulation and food intake. Recent experiments demonstrated that 5-HT1A receptor antagonists reduce food intake. We sought to examine the micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370f1174e19d3f626b953ec342e120f9
https://doi.org/10.1016/j.pbb.2013.09.003
https://doi.org/10.1016/j.pbb.2013.09.003
Autor:
Claire V. Cella, Jenna Hanmer, Michael Hutton, David O. Calligaro, Aaron Simmons, Annalisa Cavallini, Peter Davies, Hugh Nuthall, Laura J. Bloem, Philip G. Szekeres, Michael J. O'Neill, Suchira Bose, Mark A Ward, Helen Sims, Jeff W. Cramer, Tracey K. Murray, Elizabeth Eberle, Lisa Baschirotto, Dan L. Czilli, Ana I. Mateo, Michel Goedert, Sandra Sossick
Publikováno v:
Alzheimer's & Dementia. 8
Background: Neurofibrillary tangles (NFT), one of the hallmarks of Alzheimer’s disease (AD), are composed of paired helical filaments (PHF) of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd9969eb4a5cb1687792eeaf6cea0ba
https://doi.org/10.1016/j.jalz.2012.05.1243
https://doi.org/10.1016/j.jalz.2012.05.1243
Autor:
Calderon, Boris, Reynolds, Nichole A, Swearingen, Craig A, Carter, Quincy L, Bivi, Nicoletta, Cramer, Jeff W, Alexander, Courtney L, Siegel, Robert W, Konrad, Robert J
Publikováno v:
Journal of Applied Laboratory Medicine; Sep2023, Vol. 8 Issue 5, p896-908, 13p