Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jeff T. Hutchins"'
Autor:
Karthik Tiruthani, Carlos Cruz‐Teran, Jasper F. W. Chan, Alice Ma, Morgan McSweeney, Whitney Wolf, Shoufeng Yuan, Vincent K. M. Poon, Chris C. S. Chan, Lakshmi Botta, Brian Farrer, Ian Stewart, Alison Schaefer, Jasmine Edelstein, Priya Kumar, Harendra Arora, Jeff T. Hutchins, Anthony J. Hickey, Kwok‐Yung Yuen, Samuel K. Lai
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Soluble angiotensin‐converting enzyme 2 (ACE2) can act as a decoy molecule that neutralizes severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by blocking spike (S) proteins on virions from binding ACE2 on host cells. Based o
Externí odkaz:
https://doaj.org/article/0194f8a6b25b4295b585d8f6aa9503ad
Autor:
Xianming Huang, Rolf A. Brekken, Jeff T. Hutchins, Alan J. Schroit, Christopher C.W. Hughes, Michaela M.S. Hatch, Shen Yin, Van Nguyen, Michael J. Gray, Dan Ye, Jian Gong, Bruce D. Freimark
Supplementary Figure Legend. Table 1. Antibodies for flow cytometry and immunohistochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa77714153b29c2ed165a218a8dd4219
https://doi.org/10.1158/2326-6066.22538729.v1
https://doi.org/10.1158/2326-6066.22538729.v1
Autor:
Xianming Huang, Rolf A. Brekken, Jeff T. Hutchins, Alan J. Schroit, Christopher C.W. Hughes, Michaela M.S. Hatch, Shen Yin, Van Nguyen, Michael J. Gray, Dan Ye, Jian Gong, Bruce D. Freimark
Supplemental figure 1. Binding of mch1N11 antibody to PS in the presence of mouse beta 2-glycoprotein I. Supplemental Figure 2. Quantitative immunohistochemistry of K1735 tumors following combination therapy of PS-targeting antibody and anti-PD-1 ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21492773f55abb2625e40ec994dd0b4f
https://doi.org/10.1158/2326-6066.22538726
https://doi.org/10.1158/2326-6066.22538726
Autor:
Xianming Huang, Rolf A. Brekken, Jeff T. Hutchins, Alan J. Schroit, Christopher C.W. Hughes, Michaela M.S. Hatch, Shen Yin, Van Nguyen, Michael J. Gray, Dan Ye, Jian Gong, Bruce D. Freimark
In tumor-bearing animals, the membrane phospholipid phosphatidylserine (PS) suppresses immune responses, suggesting that PS signaling could counteract the antitumor effect of antibody-driven immune checkpoint blockade. Here, we show that treating mel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6596fd7fc2cad34e24b3c4012bc84926
https://doi.org/10.1158/2326-6066.c.6548870
https://doi.org/10.1158/2326-6066.c.6548870
Autor:
Jin Wang, Andrea Hall, Geoffrey W. Henson, Brenda Ames, Mohamed Aljarah, Andrea Brancale, Elena Gorovits, Arnaud Gilles, John Vernachio, Karolina Madela, Babita Ganguly, Stanley D. Chamberlain, Jerry Muhammad, Nicola Zonta, Joseph M. Patti, Jeff T. Hutchins, Christopher McGuigan, Alexander A. Kolykhalov
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4850-4854
We herein report a novel double pro-drug approach applied to the anti-HCV agent 2'-beta-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic prodrugs of the monophosphate of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a382b4a36e18f81eb709e0c79135f93
https://doi.org/10.1016/j.bmcl.2010.06.094
https://doi.org/10.1016/j.bmcl.2010.06.094
Autor:
Andrea Hall, Christopher McGuigan, K. Dawn Bryant, Babita Ganguly, Arnaud Gilles, Robin Walters, Jerry Muhammad, John Vernachio, Mohamed Aljarah, Nicholas Raja, Elena Gorovits, Geoffrey W. Henson, Jin Wang, Sabrina Holl, Damound Hunley, Brenda Ames, Alexander A. Kolykhalov, Stanley D. Chamberlain, Karolina Madela, Yule Liu, Sarah Jones, Jeff T. Hutchins
Publikováno v:
Journal of Medicinal Chemistry. 53:4949-4957
Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies. Nucleoside analogues with improved exposure, efficacy, and selectivity are recognized as likely key components of future HCV therapy. 2'-C-Methylgua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2345d90a11a7538923cd94c8e0e77823
https://doi.org/10.1021/jm1003792
https://doi.org/10.1021/jm1003792
Autor:
John Vernachio, Jeff T. Hutchins, Andrea Hall, Paul Domanski, Elena Gorovits, Brenda Ames, Cathy Y. Chang, Joseph M. Patti, Peter J. Syribeys
Publikováno v:
Microbial Pathogenesis. 43:55-66
Enterococci are opportunistic pathogens known to cause numerous clinical infections and complications in humans. Adhesin-mediated binding to extracellular matrix (ECM) proteins of the host is thought to be a crucial step in the pathogenesis of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b0a7a950a94e9627d5821b66caa749
https://doi.org/10.1016/j.micpath.2007.03.003
https://doi.org/10.1016/j.micpath.2007.03.003
Autor:
Andrea Hall, Patel Pratisksha, Jeff T. Hutchins, Michael A. Johnson, Julia M. Ross, John Vernachio, Elena Gorovits, Paul Domanski, Peter J. Syribeys, Joseph M. Patti
Publikováno v:
Infection and Immunity. 71:6864-6870
The Staphylococcus aureus MSCRAMM (microbial surface components recognizing adhesive matrix molecules) protein clumping factor A (ClfA) has been shown to be a critical virulence factor in several experimental models of infection. This report describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367b6aa8c95c9be6c49a417e84773913
https://doi.org/10.1128/iai.71.12.6864-6870.2003
https://doi.org/10.1128/iai.71.12.6864-6870.2003
Autor:
Katherine E. Kilpatrick, Janet H. Parham, Gregory Pahel, J. Patrick Condreay, Jeff T. Hutchins, Eric P. Dixon, Sandy A. Kerner
Publikováno v:
Hybridoma and Hybridomics. 21:237-243
Previously we demonstrated the rapid generation of affinity matured monoclonal antibody (MAb) producing cell lines following gene gun delivery of DNA using a mammalian expression vector (pAlpha/hFc), which enables the expression of human Fc-chimera p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7883583843acdf3cc4c1c1807468dbb
https://doi.org/10.1089/153685902760213840
https://doi.org/10.1089/153685902760213840
Publikováno v:
Cytotechnology. 35:181-187
To support and meet the demand for recombinant proteins early in the drug discovery process, much work has been directed toward improving the methods used for transient gene transfection and expression. A factor which could potentially affect the out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::876e49f45e256e0ad83058a99c3a8e29
https://doi.org/10.1023/a:1013131415382
https://doi.org/10.1023/a:1013131415382