Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Jeff Skinner"'
Autor:
Carolina M Andrade, Manuela Carrasquilla, Usama Dabbas, Jessica Briggs, Hannah van Dijk, Nikolay Sergeev, Awa Sissoko, Moussa Niangaly, Christina Ntalla, Emily LaVerriere, Jeff Skinner, Klara Golob, Jeremy Richter, Hamidou Cisse, Shanping Li, Jason A Hendry, Muhammad Asghar, Didier Doumtabe, Anna Farnert, Thomas Ruppert, Daniel E Neafsey, Kassoum Kayentao, Safiatou Doumbo, Aissata Ongoiba, Peter D Crompton, Boubacar Traore, Bryan Greenhouse, Silvia Portugal
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2349-2375 (2024)
Abstract Persistence of malaria parasites in asymptomatic hosts is crucial in areas of seasonally-interrupted transmission, where P. falciparum bridges wet seasons months apart. During the dry season, infected erythrocytes exhibit extended circulatio
Externí odkaz:
https://doaj.org/article/9b3ff732567a4f43bf41822cfe3ec2fd
Autor:
Triniti C. Turner, Charles Arama, Aissata Ongoiba, Safiatou Doumbo, Didier Doumtabé, Kassoum Kayentao, Jeff Skinner, Shanping Li, Boubacar Traore, Peter D. Crompton, Anton Götz
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-13 (2021)
Abstract Background Plasmodium falciparum causes the majority of malaria cases worldwide and children in sub-Saharan Africa are the most vulnerable group affected. Non-sterile clinical immunity that protects from symptoms develops slowly and is relat
Externí odkaz:
https://doaj.org/article/f4c72f0bae1242f1a9377a1569d3d7d4
Autor:
Rajan Guha, Anna Mathioudaki, Safiatou Doumbo, Didier Doumtabe, Jeff Skinner, Gunjan Arora, Shafiuddin Siddiqui, Shanping Li, Kassoum Kayentao, Aissata Ongoiba, Judith Zaugg, Boubacar Traore, Peter D Crompton
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009430 (2021)
In malaria-naïve children and adults, Plasmodium falciparum-infected red blood cells (Pf-iRBCs) trigger fever and other symptoms of systemic inflammation. However, in endemic areas where individuals experience repeated Pf infections over many years,
Externí odkaz:
https://doaj.org/article/86ed53875a52418bb875339a289caf1c
Autor:
Nyamekye Obeng-Adjei, Silvia Portugal, Tuan M. Tran, Takele B. Yazew, Jeff Skinner, Shanping Li, Aarti Jain, Philip L. Felgner, Ogobara K. Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter D. Crompton
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 425-439 (2015)
Malaria-specific antibody responses are short lived in children, leaving them susceptible to repeated bouts of febrile malaria. The cellular and molecular mechanisms underlying this apparent immune deficiency are poorly understood. Recently, T follic
Externí odkaz:
https://doaj.org/article/dd9cdef30a4e49f78bee0a1b9d6a7700
Autor:
Nyamekye Obeng-Adjei, Silvia Portugal, Prasida Holla, Shanping Li, Haewon Sohn, Abhijit Ambegaonkar, Jeff Skinner, Georgina Bowyer, Ogobara K Doumbo, Boubacar Traore, Susan K Pierce, Peter D Crompton
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006576 (2017)
Many chronic infections, including malaria and HIV, are associated with a large expansion of CD21-CD27- 'atypical' memory B cells (MBCs) that exhibit reduced B cell receptor (BCR) signaling and effector functions. Little is known about the conditions
Externí odkaz:
https://doaj.org/article/97edc17bad894c08b725b2f75264ffc6
Autor:
Kaveh Abdi, Tsute Chen, Brian A Klein, Albert K Tai, Jill Coursen, Xiangdong Liu, Jeff Skinner, Saravanan Periasamy, Youngnim Choi, Benedikt M Kessler, Robert J Palmer, Apostolos Gittis, Polly Matzinger, Margaret J Duncan, Nevil J Singh
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182164 (2017)
The oral cavity is home to unique resident microbial communities whose interactions with host immunity are less frequently studied than those of the intestinal microbiome. We examined the stimulatory capacity and the interactions of two oral bacteria
Externí odkaz:
https://doaj.org/article/36a174eb71514f4389dda76bff7d88b4
Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria
Autor:
Emile B. Gordon, Geoffrey T. Hart, Tuan M. Tran, Michael Waisberg, Munir Akkaya, Jeff Skinner, Severin Zinöcker, Mirna Pena, Takele Yazew, Chen-Feng Qi, Louis H. Miller, Susan K. Pierce
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) is a common form of severe malaria resulting in nearly 700,000 deaths each year in Africa alone. At present, there is no adjunctive therapy
Externí odkaz:
https://doaj.org/article/d9d29f731e7d438284e52153462fb045
Autor:
Silvia Portugal, Christopher M Tipton, Haewon Sohn, Younoussou Kone, Jing Wang, Shanping Li, Jeff Skinner, Kimmo Virtaneva, Daniel E Sturdevant, Stephen F Porcella, Ogobara K Doumbo, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Inaki Sanz, Susan K Pierce, Peter D Crompton
Publikováno v:
eLife, Vol 4 (2015)
Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a large increase in atypical memory B cells (MBCs) that resemble B cells expanded in a variety of
Externí odkaz:
https://doaj.org/article/dbe216d62e4143a0ae31dc065f9d4c30
Autor:
Krishanthi S Subramaniam, Jeff Skinner, Emil Ivan, Eugene Mutimura, Ryung S Kim, Catherine M Feintuch, Silvia Portugal, Kathryn Anastos, Peter D Crompton, Johanna P Daily
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124412 (2015)
HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens; ho
Externí odkaz:
https://doaj.org/article/592a4f22b779452588563fe1e7b7b805
Autor:
Silvia Portugal, Jacqueline Moebius, Jeff Skinner, Safiatou Doumbo, Didier Doumtabe, Younoussou Kone, Seydou Dia, Kishore Kanakabandi, Daniel E Sturdevant, Kimmo Virtaneva, Stephen F Porcella, Shanping Li, Ogobara K Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter D Crompton
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004079 (2014)
In malaria-naïve individuals, Plasmodium falciparum infection results in high levels of parasite-infected red blood cells (iRBCs) that trigger systemic inflammation and fever. Conversely, individuals in endemic areas who are repeatedly infected are
Externí odkaz:
https://doaj.org/article/e4e9b922a4e742aba4bc1050044c01c3