Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jeff S. Piotrowski"'
Autor:
Fabián A. Cornejo, Claudia Muñoz-Villagrán, Roberto A. Luraschi, María P. Sandoval-Díaz, Camila A. Cancino, Benoit Pugin, Eduardo H. Morales, Jeff S. Piotrowski, Juan M. Sandoval, Claudio C. Vásquez, Felipe A. Arenas
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Metal(loid) salts were used to treat infectious diseases in the past due to their exceptional biocidal properties at low concentrations. However, the mechanism of their toxicity has yet to be fully elucidated. The production of reactive oxygen specie
Externí odkaz:
https://doaj.org/article/0b500d21e68b42f0b9b89b5040a582df
Autor:
Shinsuke Ohnuki, Itsuki Ogawa, Kaori Itto-Nakama, Fachuang Lu, Ashish Ranjan, Mehdi Kabbage, Abraham Abera Gebre, Masao Yamashita, Sheena C. Li, Yoko Yashiroda, Satoshi Yoshida, Takeo Usui, Jeff S. Piotrowski, Brenda J. Andrews, Charles Boone, Grant W. Brown, John Ralph, Yoshikazu Ohya
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Morphological profiling is an omics-based approach for predicting intracellular targets of chemical compounds in which the dose-dependent morphological changes induced by the compound are systematically compared to the morphological changes
Externí odkaz:
https://doaj.org/article/6b96edf748304f4c8e87ae0445938766
Autor:
Scott Bottoms, Quinn Dickinson, Mick McGee, Li Hinchman, Alan Higbee, Alex Hebert, Jose Serate, Dan Xie, Yaoping Zhang, Joshua J. Coon, Chad L. Myers, Robert Landick, Jeff S. Piotrowski
Publikováno v:
Microbial Cell Factories, Vol 17, Iss 1, Pp 1-12 (2018)
Abstract Background Gamma valerolactone (GVL) treatment of lignocellulosic bomass is a promising technology for degradation of biomass for biofuel production; however, GVL is toxic to fermentative microbes. Using a combination of chemical genomics wi
Externí odkaz:
https://doaj.org/article/3e5cf6c6a7584b62ba3efc72f00e0cc1
Autor:
Eduardo H. Morales, Camilo A. Pinto, Roberto Luraschi, Claudia M. Muñoz-Villagrán, Fabián A. Cornejo, Scott W. Simpkins, Justin Nelson, Felipe A. Arenas, Jeff S. Piotrowski, Chad L. Myers, Hirotada Mori, Claudio C. Vásquez
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE. coli, and that the heme precursor 5-aminolevu
Externí odkaz:
https://doaj.org/article/fdd5a80f0c384b64abef9129985eb409
Autor:
Benjamin M. Vincent, Daniel F. Tardiff, Jeff S. Piotrowski, Rebecca Aron, Matthew C. Lucas, Chee Yeun Chung, Helene Bacherman, YiQun Chen, Michelle Pires, Radha Subramaniam, Dimple B. Doshi, Heather Sadlish, Waseem K. Raja, Eric J. Solís, Vikram Khurana, Bertrand Le Bourdonnec, Robert H. Scannevin, Kenneth J. Rhodes
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2742-2754.e31 (2018)
Summary: The lack of disease-modifying treatments for neurodegenerative disease stems in part from our rudimentary understanding of disease mechanisms and the paucity of targets for therapeutic intervention. Here we used an integrated discovery parad
Externí odkaz:
https://doaj.org/article/b5e6241913a94966ac7db88b4002e1b5
Autor:
Kimberly C. Lemmer, Weiping Zhang, Samantha J. Langer, Alice C. Dohnalkova, Dehong Hu, Rachelle A. Lemke, Jeff S. Piotrowski, Galya Orr, Daniel R. Noguera, Timothy J. Donohue
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Lipids from microbes offer a promising source of renewable alternatives to petroleum-derived compounds. In particular, oleaginous microbes are of interest because they accumulate a large fraction of their biomass as lipids. In this study, we
Externí odkaz:
https://doaj.org/article/c291e532b948447ebf35d48997c96929
Autor:
Mami Yoshimura, Yoko Yashiroda, Hiroyuki Osada, Scott W. Simpkins, Chad L. Myers, Minoru Yoshida, Jeff S. Piotrowski, Charles Boone, Hamid Safizadeh, Justin Nelson, Sheena C. Li, Hiroyuki Hirano
Publikováno v:
Journal of Chemical Information and Modeling
A common strategy for identifying molecules likely to possess a desired biological activity is to search large databases of compounds for high structural similarity to a query molecule that demonstrates this activity, under the assumption that struct
Autor:
Mehdi Kabbage, E. Thill, Kurt Hockemeyer, Jeff S. Piotrowski, Paul L. Koch, John Ralph, Nathaniel M. Westrick
Publikováno v:
Plant Pathology. 69:112-119
Plant‐based antifungal agents offer an alternative to synthetic fungicides in amenity turfgrass disease management. Poacic acid is a by‐product of the biofuel production process that has exhibited antifungal activity, and the objective of this re
Autor:
Keisuke Tomita, Kazunori Okada, Makoto Kawamukai, Reika Okamoto, Hideaki Nojiri, Yoko Yashiroda, Mami Yoshimura, Minoru Yoshida, Sheena C. Li, Yasuhiro Matsuo, Yumi Kawamura, Charles Boone, Hiromi Kimura, Jeff S. Piotrowski
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Momilactone B is a natural product with dual biological activities, including antimicrobial and allelopathic properties, and plays a major role in plant chemical defense against competitive plants and pathogens. The pharmacological effects of momilac
Autor:
Logan Stiegman, Manish Ranjan, Ashish Ranjan, Nathaniel M. Westrick, Jeff S. Piotrowski, Craig R. Grau, Mehdi Kabbage, Shawn P. Conley, Ryan Kessens, Sachin Jain, Damon L. Smith
Publikováno v:
Plant Biotechnology Journal
Summary Sclerotinia sclerotiorum, a predominately necrotrophic fungal pathogen with a broad host range, causes a significant yield‐limiting disease of soybean called Sclerotinia stem rot. Resistance mechanisms against this pathogen in soybean are p