Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jeff Rollins"'
Autor:
Julia Bercher, Ralf Dechend, Nadine Haase, Ivo Bendix, Babbette LaMarca, Alexandra Gellhaus, Donald Foster, Stuart Milstein, Sarfraz Shaikh, Kristin Thiele, Michaela Golic, Florian Herse, Hanna Napieczynska, Arnd Heuser, Kristin Kräker, Dominik N. Müller, Jeff Rollins, Tuyen Nguyen, Svetlana Shulga-Morskaya, Mark W. Cunningham, Gerd Wallukat, Meray Serdar
Publikováno v:
J Clin Invest
Preeclampsia, with the hallmark features of new-onset hypertension and proteinuria after 20 weeks of gestation, is a major cause of fetal and maternal morbidity and mortality. Studies have demonstrated a role for the renin-angiotensin system (RAS) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22f12c415e98912c0b0012c7a02daa8
https://doi.org/10.1172/jci99417
https://doi.org/10.1172/jci99417
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
Autor:
Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia I. Anglero-Rodriguez, Lan T. H. Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature biotechnology. 40(10)
Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a036125a57dba90192959ce807480ec6
https://pubmed.ncbi.nlm.nih.gov/35654979
https://pubmed.ncbi.nlm.nih.gov/35654979
Autor:
Ralf Dechend, Mark W. Cunningham, Sarfraz Shaikh, Florian Herse, Nadine Haase, Dominik N. Müller, Tuyen Nguyen, Babbette LaMarca, Svetlana Shulga-Morskaya, Jeff Rollins, Don Foster, Stuart Milstein, Kristin Kräker, Michaela Golic
Publikováno v:
Pregnancy Hypertension. 13:S63
Introduction Preeclampsia is a common and devastating pregnancy disorder, featuring hypertension and proteinuria. Studies have demonstrated that dysregulation of Renin-Angiotensin-System (RAS) is involved in the pathogenesis of the disease; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b922b99e33781eb9b359d19e2df369b3
https://doi.org/10.1016/j.preghy.2018.08.187
https://doi.org/10.1016/j.preghy.2018.08.187