Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation

Autor: Charles E. Hendrick, Jeff R. Jorgensen, Charu Chaudhry, Iulia I. Strambeanu, Jean-Francois Brazeau, Jamie Schiffer, Zhicai Shi, Jennifer D. Venable, Scott E. Wolkenberg

Publikováno v: ACS Medicinal Chemistry Letters. 13:1182-1190

A platform to accelerate optimization of proteolysis targeting chimeras (PROTACs) has been developed using a direct-to-biology (D2B) approach with a focus on linker effects. A large number of linker analogs-with varying length, polarity, and rigidity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c50fdf861b4d5a7137237ad829f62b
https://doi.org/10.1021/acsmedchemlett.2c00124

ESCRT-III and ER–PM contacts maintain lipid homeostasis

Autor: Jeremy M. Baskin, Scott D. Emr, Jeff R Jorgensen, Benoît Kornmann, Agnès H. Michel, Reika Tei

Publikováno v: Molecular Biology of the Cell

Eukaryotic cells are compartmentalized into organelles by intracellular membranes. While the organelles are distinct, many of them make intimate contact with one another. These contacts were first observed in the 1950s, but only recently have the fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91c990425c87cf29a6a1ba655a06720
http://europepmc.org/articles/PMC7353149

The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites

Autor: Arash Bashirullah, Scott D. Emr, Jeremy T. Smyth, Sarah D. Neuman, Jeff R Jorgensen, Amy T. Cavanagh, Jane E. Selegue

Publikováno v: J Cell Sci

Membrane contact sites are critical junctures for organelle signaling and communication. Endoplasmic reticulum–plasma membrane (ER–PM) contact sites were the first membrane contact sites to be described; however, the protein composition and molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfaf416be3292229ae9b89a3fde5fc54
https://pubmed.ncbi.nlm.nih.gov/34415038

Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention

Autor: Jeff R Jorgensen, Douglas B. Gould, Marion Jeanne

Publikováno v: Circulation, vol 131, iss 18
Jeanne, M; Jorgensen, J; & Gould, DB. (2015). Molecular and genetic analyses of collagen type IV mutant mouse models of spontaneous intracerebral hemorrhage identify mechanisms for stroke prevention. Circulation, 131(18), 1555-1565. doi: 10.1161/CIRCULATIONAHA.114.013395. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4bk9t8jp

Background— Collagen type IV alpha1 (COL4A1) and alpha2 (COL4A2) form heterotrimers critical for vascular basement membrane stability and function. Patients with COL4A1 or COL4A2 mutations suffer from diverse cerebrovascular diseases, including cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e079b9de357ab99f5614ef5dcca8527
https://doi.org/10.1161/circulationaha.114.013395

COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke

Autor: Valerie Valant, Steven M. Greenberg, Jack Favor, Jeff R Jorgensen, W. Berkeley Kauffman, Marion Jeanne, Cassandre Labelle-Dumais, Jonathan Rosand, Douglas B. Gould, Grazia M.S. Mancini

Publikováno v: Am. J. Hum. Genet. 90, 91-101 (2012)
American Journal of Human Genetics, 90(1), 91-101. Cell Press

Collagen, type IV, alpha 1 (COL4A1) and alpha 2 (COL4A2) form heterotrimers and are abundant components of basement membranes, including those of the cerebral vasculature. COL4A1 mutations are an increasingly recognized cause of multisystem disorders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d44fde65c81a7249281047fd63f1b0b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=7105