Iron chelators in cancer therapy

Autor: Ola Ibrahim, Jeff O'Sullivan

Publikováno v: BioMetals. 33:201-215

Iron chelators have long been a target of interest as anticancer agents. Iron is an important cellular resource involved in cell replication, metabolism and growth. Iron metabolism is modulated in cancer cells reflecting their increased replicative d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53d8bf2c0dfbec820aee07023173be1
https://doi.org/10.1007/s10534-020-00243-3

Salivary N-glycosylation as a biomarker of oral cancer: A pilot study

Autor: Gavin P. Davey, Jeff O'Sullivan, Stefan Mittermayr, Nicoleta Sinevici, Jonathan Bones

Publikováno v: Glycobiology. 29:726-734

Reliable biomarkers for oral cancer (OC) remain scarce, and routine tests for the detection of precancerous lesions are not routine in the clinical setting. This study addresses a current unmet need for more sensitive and quantitative tools for the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af7e7ae59c548c658eda2a05f33022d
https://doi.org/10.1093/glycob/cwz046

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Autor: Francesca Vanni, Niamh H McCabe, Stefania Lamponi, Cristina Ulivieri, Federica Sarno, Fulvio Saccoccia, Sandra Gemma, Giulia Chemi, David W. Christianson, Ola Ibrahim, Margherita Brindisi, Simone Brogi, Giovina Ruberti, Stefano Federico, Manfred Jung, Giuseppe Campiani, Nicola Relitti, Vincent P. Kelly, Daniela M. Zisterer, Stefania Butini, Richard C. Turkington, Antonella Di Costanzo, Patricia Hannon Barroeta, Rebecca Amet, Lucia Altucci, Magda Ghanim, Jeff O'Sullivan, Alessandro Grillo, Jeremy D. Osko, A Prasanth Saraswati, Daniel Herp

Publikováno v: Saraswati, A P, Relitti, N, Brindisi, M, Osko, J D, Chemi, G, Federico, S, Grillo, A, Brogi, S, McCabe, N H, Turkington, R C, Ibrahim, O, O'Sullivan, J, Lamponi, S, Ghanim, M, Kelly, V P, Zisterer, D, Amet, R, Hannon Barroeta, P, Vanni, F, Ulivieri, C, Herp, D, Sarno, F, Di Costanzo, A, Saccoccia, F, Ruberti, G, Jung, M, Altucci, L, Gemma, S, Butini, S, Christianson, D W & Campiani, G 2020, ' Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation ', ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 11, pp. 2268-2276 . https://doi.org/10.1021/acsmedchemlett.0c00395
ACS Med Chem Lett
ACS medicinal chemistry letters (2020). doi:10.1021/acsmedchemlett.0c00395
info:cnr-pdr/source/autori:A Prasanth Saraswati 1, Nicola Relitti 1, Margherita Brindisi 1, Jeremy D Osko 2, Giulia Chemi 1, Stefano Federico 1, Alessandro Grillo 1, Simone Brogi 3, Niamh H McCabe 4, Richard C Turkington 4, Ola Ibrahim 5, Jeffrey O'Sullivan 5, Stefania Lamponi 1, Magda Ghanim 6, Vincent P Kelly 6, Daniela Zisterer 6, Rebecca Amet 6, Patricia Hannon Barroeta 6, Francesca Vanni 7, Cristina Ulivieri 7, Daniel Herp 8, Federica Sarno 9, Antonella Di Costanzo 9, Fulvio Saccoccia 10, Giovina Ruberti 10, Manfred Jung 8, Lucia Altucci 9, Sandra Gemma 1, Stefania Butini 1, David W Christianson 2, Giuseppe Campiani/titolo:Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation/doi:10.1021%2Facsmedchemlett.0c00395/rivista:ACS medicinal chemistry letters/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
ACS Medicinal Chemistry Letters

[Image: see text] Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-sel

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https://pure.qub.ac.uk/en/publications/spiroindolinecapped-selective-hdac6-inhibitors-design-synthesis-structural-analysis-and-biological-evaluation(5bed77f3-2eb8-4bef-8802-360242d740c1).html

Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue

Autor: Barry J. Ryan, Jean-Louis Grolleau, Christian Carpéné, Gary T. M. Henehan, Jessica Fontaine, Jeff O'Sullivan, Cécile Peiro, Gemma K. Kinsella, Wiem Haj Ahmed

Publikováno v: Medicines
Articles
Medicines, Vol 7, Iss 18, p 18 (2020)
Volume 7
Issue 4

Background: Methylxanthines including caffeine and theobromine are widely consumed compounds and were recently shown to interact with bovine copper-containing amine oxidase. To the best of our knowledge, no direct demonstration of any interplay betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca82d36668cfc690f6fbe6b57697f664
http://europepmc.org/articles/PMC7235778

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Autor: Grégory Menchon, Lucia Altucci, Giulia Chemi, Simone Brogi, Michel O. Steinmetz, Angela Nebbioso, Natacha Olieric, Daniela M. Zisterer, Francisco de Asís Balaguer, Stefania Butini, Rebecca Amet, Cristina Ulivieri, Alessandro Grillo, Jeff O'Sullivan, Isabel Barasoain, Margherita Brindisi, J. Fernando Díaz, Ettore Novellino, Roberta Spaccapelo, Daniel Lucena-Agell, Ludovica Lopresti, Andrea E. Prota, Sandra Gemma, Mariarosaria Conte, Stefania Magnano, Cosima T. Baldari, Gloria Alfano, Giuseppe Campiani, Paula Kinsella, Tuhina Khan, Lucia Morbidelli, Ola Ibrahim

Publikováno v: European Journal of Medicinal Chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname

Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. Benzoxazepines were recent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac07af3e053396026a7fa9fca0f7aa6
http://hdl.handle.net/11391/1447652