Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Jeff M. Bronstein"'
Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use
Autor:
Kathie J. Ngo, Kimberly C. Paul, Darice Wong, Cynthia D. J. Kusters, Jeff M. Bronstein, Beate Ritz, Brent L. Fogel
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Parkinson’s disease (PD), the second most common neurodegenerative disorder, develops sporadically, likely through a combination of polygenic and environmental factors. Previous studies associate pesticide exposure and genes involved in ly
Externí odkaz:
https://doaj.org/article/cdd5b0b435334b6db366efb8ca00eb22
Autor:
Dayoon Kwon, Keren Zhang, Kimberly C. Paul, Aline D. Folle, Irish Del Rosario, Jonathan P. Jacobs, Adrienne M. Keener, Jeff M. Bronstein, Beate Ritz
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract It has been suggested that gut microbiota influence Parkinson’s disease (PD) via the gut–brain axis. Here, we examine associations between diet and gut microbiome composition and its predicted functional pathways in patients with PD. We
Externí odkaz:
https://doaj.org/article/84113f7bdfa74f85b1afd7f29a4c6518
Autor:
Keren Zhang, Kimberly Paul, Jonathan P. Jacobs, Myles G. Cockburn, Jeff M. Bronstein, Irish del Rosario, Beate Ritz
Publikováno v:
Environmental Health, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Organophosphorus pesticides (OP) have been associated with various human health conditions. Animal experiments and in-vitro models suggested that OP may also affect the gut microbiota. We examined associations between ambient chro
Externí odkaz:
https://doaj.org/article/18c98581b243464a85c9660d9c7966d4
Autor:
Hash Brown Taha, Simon Hornung, Suman Dutta, Leony Fenwick, Otmane Lahgui, Kathryn Howe, Nour Elabed, Irish del Rosario, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Horacio Kaufmann, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz, Gal Bitan
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/85fb98a9deb841f7a68e9dae119d15cf
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Long-term air pollution (AP) exposure, including diesel exhaust exposure, is increasingly being recognized as a major contributor to the development of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. How AP increa
Externí odkaz:
https://doaj.org/article/f10f7d5d7297421e95f1173b777f60f1
Autor:
Jason A. Chen, Zhongbo Chen, Hyejung Won, Alden Y. Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, Christine Payan, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-Francois Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al-Chalabi, Daniel H. Geschwind, Giovanni Coppola
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease for which the genetic contribution is incompletely understood. Methods We conducted a joint analysis of 5,523,934 imputed SNPs in two newly-genotyped progres
Externí odkaz:
https://doaj.org/article/38fd283c780d47908af18442210dfcca
Autor:
Yu-Hsuan Chuang, Kimberly C. Paul, Jeff M. Bronstein, Yvette Bordelon, Steve Horvath, Beate Ritz
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-12 (2017)
Abstract Background Several articles suggest that DNA methylation levels in blood relate to Parkinson’s disease (PD) but there is a need for a large-scale study that involves suitable population based controls. The purposes of the study were: (1) t
Externí odkaz:
https://doaj.org/article/436944e3c4d3471ca47975a42ae7f42a
Publikováno v:
Biomedicines, Vol 8, Iss 7, p 197 (2020)
Parkinson’s disease is a common neurodegenerative disorder leading to severe disability. The clinical features reflect progressive neuronal loss, especially involving the dopaminergic system. The causes of Parkinson’s disease are slowly being unc
Externí odkaz:
https://doaj.org/article/94be61a932354c38887f8b5c71f66f70
Autor:
Kelley C. O’Donnell, Aaron Lulla, Mark C. Stahl, Nickolas D. Wheat, Jeff M. Bronstein, Alvaro Sagasti
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 5, Pp 571-582 (2014)
α-synuclein (aSyn) expression is implicated in neurodegenerative processes, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In animal models of these diseases, axon pathology often precedes cell death, raising the question
Externí odkaz:
https://doaj.org/article/5494ba12d2304d82a851577e4b68f958
Autor:
Shannon L. Rhodes, Daniel D. Buchanan, Ismaïl Ahmed, Kent D. Taylor, Marie-Anne Loriot, Janet S. Sinsheimer, Jeff M. Bronstein, Alexis Elbaz, George D. Mellick, Jerome I. Rotter, Beate Ritz
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 172-178 (2014)
Pathologic features of Parkinson's disease (PD) include death of dopaminergic neurons in the substantia nigra, presence of α-synuclein containing Lewy bodies, and iron accumulation in PD-related brain regions. The observed iron accumulation may be c
Externí odkaz:
https://doaj.org/article/d6ee28386d92491e81b92b9ea51641ec