Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jeff Lohman"'
Autor:
Laura Terraneo, Ashok Malavalli, Paola Bianciardi, Eleonora Virgili, Kim D. Vandegriff, Anna Caretti, Jeff Lohman, Michele Samaja, Mark A. Young
Publikováno v:
Transfusion. 54:2045-2054
Background Extracellular hemoglobin (Hb)-based oxygen carriers (HBOCs) are under extensive consideration as oxygen therapeutics. Their effects on cellular mechanisms related to apoptosis are of particular interest, because the onset of proapoptotic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2bb0c9d9b398076bc7fac9afde8e0ba
https://doi.org/10.1111/trf.12643
https://doi.org/10.1111/trf.12643
Publikováno v:
Journal of Cardiothoracic and Vascular Anesthesia. 23:339-347
Objectives Hemospan (Sangart Inc, San Diego, CA) (MP4) is a hemoglobin-based oxygen carrier consisting of human hemoglobin modified with polyethylene glycol. This study evaluated the effects of MP4 on blood volume, hemodynamics, and metabolic stabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29a0ae4836a5086beebf12289ce424b
https://doi.org/10.1053/j.jvca.2008.08.006
https://doi.org/10.1053/j.jvca.2008.08.006
Publikováno v:
Journal of Applied Physiology. 97:1527-1534
We have reported a new polyethylene glycol (PEG)-modified, hemoglobin-based O2 carrier (MP4) with novel properties, including a large molecular excluded volume and low Po2 necessary to obtain 50% O2 (∼6 Torr). To evaluate the ability of MP4 to tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1f2c5a6ef8e791b88a319101daf3d3
https://doi.org/10.1152/japplphysiol.00404.2004
https://doi.org/10.1152/japplphysiol.00404.2004
Publikováno v:
Transfusion. 43:509-516
Background Vasoconstriction has been an obstacle to clinical development of Hb-based O2 carriers. It is proposed that this limitation can be overcome by increasing molecular size and oxygen affinity. Study design and methods Surface-modified Hb (MP4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8adf12cb2ec78aa0c936502d9ecce0
https://doi.org/10.1046/j.1537-2995.2003.00341.x
https://doi.org/10.1046/j.1537-2995.2003.00341.x
Autor:
Kim D, Vandegriff, Ashok, Malavalli, Jeff, Lohman, Mark A, Young, Laura, Terraneo, Eleonora, Virgili, Paola, Bianciardi, Anna, Caretti, Michele, Samaja
Publikováno v:
Transfusion. 54(8)
Extracellular hemoglobin (Hb)-based oxygen carriers (HBOCs) are under extensive consideration as oxygen therapeutics. Their effects on cellular mechanisms related to apoptosis are of particular interest, because the onset of proapoptotic pathways may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a21c06a0fb9b663d1e5d66ecdff2330f
https://pubmed.ncbi.nlm.nih.gov/24673504
https://pubmed.ncbi.nlm.nih.gov/24673504
Autor:
Robert M. Winslow, Ashok Malavalli, Eva Jiang, Kim D. Vandegriff, Jeff Lohman, Michele Samaja, Charles Minn, Mark A. Young
Publikováno v:
The Biochemical journal. 399(3)
Haemoglobin-based oxygen carriers can undergo oxidation of ferrous haemoglobin into a non-functional ferric form with enhanced rates of haem loss. A recently developed human haemoglobin conjugated to maleimide-activated poly(ethylene glycol), termed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1797bff210953c5600ea6dc98b9f1922
https://pubmed.ncbi.nlm.nih.gov/16813564
https://pubmed.ncbi.nlm.nih.gov/16813564
Autor:
Elisabeth Malm, Jeff Lohman, Mark A. Young, B. Thomas Kjellstrom, Robert M. Winslow, Dan Drobin, Ashok Malavalli, Kim D. Vandegriff
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 96(5)
Cell-free Hb increases systemic and pulmonary pressure and resistance and reduces cardiac output and heart rate in animals and humans, effects that have limited their clinical development as “blood substitutes.” The primary aim of this study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885117b732dca40348791067e80a510e
https://pubmed.ncbi.nlm.nih.gov/14729723
https://pubmed.ncbi.nlm.nih.gov/14729723
Autor:
Jeff Lohman, Henry C. Mayer
Publikováno v:
Review of Social Economy. 42:330-338
For almost 10 years, a Memorandum of Unserstanding whose signatories now include seven contractors' associations and eighteen labor union locals (members of the Central Indiana Building and Construction Trades Council) has achieved a unique period of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc32fee43566e6750865889be5bd6345
https://doi.org/10.1080/00346768400000029
https://doi.org/10.1080/00346768400000029