Výsledky vyhledávání - "Jeff Labadie"

Expedient synthesis of secondary amines bound to indole resin and cleavage of resin-bound urea, amide and sulfonamide under mild conditions

Autor: Owen W. Gooding, Sukanta Bhattacharyya, Jeff Labadie

Publikováno v: Tetrahedron Letters. 44:6099-6102

Highly efficient, new protocols for the attachment of primary amines to indole aldehyde resin using Ti(O i Pr) 4 –NaBH 4 and CH(OMe) 3 –NaBH 3 CN–HOAc are reported. Mild cleavage conditions for the release of urea, amide and sulfonamide product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::366508e6bbf4fc0c576aa08f5ece2938
https://doi.org/10.1016/s0040-4039(03)01456-4

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Polymer-Assisted Parallel Solution Phase Synthesis of Substituted Benzimidazoles

Autor: Jeff Labadie, John A. Porco, Young K. Yun

Publikováno v: Synlett. 2002:0739-0742

A small library of benzimidazoles was prepared using polymer-bound reagents and scavengers. Polymer-assisted reaction of diphenyl diamines with carboxylic acids yielded o-amido-diphenylamines in the presence ofPolystyrene-Carbodiimide (PS-Carbodiimid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05acd701e35bab58b6d165b87bd8431d
https://doi.org/10.1055/s-2002-25366

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Titanium(IV) Isopropoxide Mediated Solution Phase Reductive Amination on an Automated Platform: Application in the Generation of Urea and Amide Libraries

Autor: Lanchi Vo, Sukanta Bhattacharyya, Jeff Labadie, Lisa Fan

Publikováno v: Combinatorial Chemistry & High Throughput Screening. 3:117-124

Amine libraries and their derivatives are important targets for high throughput synthesis because of their versatility as medicinal agents and agrochemicals. As a part of our efforts towards automated chemical library synthesis, a titanium(IV) isopro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fd272fc223d19378411f106664d2b3
https://doi.org/10.2174/1386207003331760

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On the Development of New Poly(styrene-oxyethylene) Graft Copolymer Resin Supports for Solid-Phase Organic Synthesis

Autor: Sylvie Baudart, Tracy L. Deegan, Owen W. Gooding, and John A. Porco Jr., Jeff Labadie, William S. Newcomb, Kevin Heisler, Paul van Eikeren

Publikováno v: Journal of Combinatorial Chemistry. 1:113-122

With the aim of creating new, improved solid supports for organic synthesis, a series of poly(styrene-oxyethylene) graft copolymers 6a - d was synthesized by anionic polymerization of ethylene oxide from a polystyrene-supported 1,3-diol 5b. Graft len

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46e4c9e210a04b9b6f2f2313d65529af
https://doi.org/10.1021/cc980016+

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Automated in situ hybridisation using Tecan robotics: a kick-start for Functional Genomics

Autor: Lanchi Vo, Peter Wright, Jeff Labadie, Young K. Yun

Publikováno v: Journal of the Association for Laboratory Automation. 6:59-61

The completion of the Human Genome Project has been hailed as the most important scientific advance of recent times. Some commentators have even predicted that this definitive knowledge of our genetic makeup will eventually transform medicine by lead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::022fc8fae67b90a20193ce2536667d5f
https://doi.org/10.1016/s1535-5535(04)00146-7

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Multistep Solution Phase Synthesis of 1,2-Diarylbenzimidazoles on the TridentTM System

Autor: Juergen Swienty-Busch, Jeff Labadie, Peter Wright, Lanchi Vo, Young K. Yun

Publikováno v: Journal of the Association for Laboratory Automation. 6:56-58

High throughput parallel organic synthesis is now a common practice in discovery chemistry research. Argonaut's modular reaction cassette technology is aimed at parallel synthesis of focused small molecule libraries. The Trident™ automated platform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf1994d6d148202bd352f04e561f6489
https://doi.org/10.1016/s1535-5535(04)00145-5

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Multistep Solution Phase Synthesis of 1,2-Diarylbenzimidazoles on the Trident™System

Autor: Lanchi Vo, Young K. Yun, Peter Wright, Jeff Labadie, Juergen Swienty-Busch

Publikováno v: JALA: Journal of the Association for Laboratory Automation. 6:56-58

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed02f68225e03d528c5aca20cf297947
https://doi.org/10.1016/s1535-5535-04-00145-5

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Copper (II)-mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries

Autor: David L. Selwood, Basil Hartzoulakis, Jeff Labadie, Sharon Rossiter, Lee Stanyer, Grant Wishart, Chi Kit Woo

Publikováno v: Journal of combinatorial chemistry. 6(3)

A N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. Cupric acetate-mediated N-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beaa436496523611785d6fa6cae6ad5f
https://pubmed.ncbi.nlm.nih.gov/15132598

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Polymer-Supported Triacetoxyborohydride: A Novel Reagent of Choice for Reductive Amination

Autor: Owen W. Gooding, Sukanta Bhattacharyya, Sunil Rana, Jeff Labadie

Publikováno v: ChemInform. 34

A novel polymer-supported triacetoxyborohydride reagent for reductive amination of aldehydes and ketones is reported. The bound reagent was found to be shelf-stable and provided broad scope and reactivity in reductive amination reactions under mild r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72433dd337d9dcd576cc8c196c509a6a
https://doi.org/10.1002/chin.200340063

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