Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jeff Jerman"'
Autor:
Rachel Forfar, Mashal Hussain, Puneet Khurana, Jennifer Cook, Steve Lewis, Dillon Popat, David Jackson, Ed McIver, Jeff Jerman, Debra Taylor, Adrian JL Clark, Li F Chan
Publikováno v:
Endocrine Connections, Vol 11, Iss 12, Pp 1-8 (2022)
The overproduction of adrenocorticotropic hormone (ACTH), in conditions such as Cushing’s disease and congenital adrenal hyperplasia (CAH), leads to significant morbidity. Current treatment with glucocorticoids does not adequately suppress plasma A
Externí odkaz:
https://doaj.org/article/a3421e3c0a9b4225a1499774c9548e05
Autor:
Conor McCloskey, Cara Rada, Elizabeth Bailey, Samantha McCavera, Hugo A van den Berg, Jolene Atia, David A Rand, Anatoly Shmygol, Yi‐Wah Chan, Siobhan Quenby, Jan J Brosens, Manu Vatish, Jie Zhang, Jerod S Denton, Michael J Taggart, Catherine Kettleborough, David Tickle, Jeff Jerman, Paul Wright, Timothy Dale, Srinivasan Kanumilli, Derek J Trezise, Steve Thornton, Pamela Brown, Roberto Catalano, Nan Lin, Sarah K England, Andrew M Blanks
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 9, Pp 1161-1174 (2014)
Abstract Abnormal uterine activity in pregnancy causes a range of important clinical disorders, including preterm birth, dysfunctional labour and post‐partum haemorrhage. Uterine contractile patterns are controlled by the generation of complex elec
Externí odkaz:
https://doaj.org/article/71bb4ab0b03e42c5af65876d7a37e163
Publikováno v:
Neuropeptides. 98:102311
Neuropathic pain is a chronic and debilitating condition characterised by episodes of hyperalgesia and allodynia. It occurs following nerve damage from disease, inflammation or injury and currently impacts up to 17% of the UK population. Existing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3147c0503bfe344054e0442262bcb31f
https://doi.org/10.1016/j.npep.2022.102311
https://doi.org/10.1016/j.npep.2022.102311
Autor:
Adrian John Clark, Li Chan, Mashal Hussain, Rachel Forfar, Jeff Jerman, Ed McIver, Debra Taylor
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
ACTH acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R) is unusual in that it is absolutely dependent
Externí odkaz:
https://doaj.org/article/35b0cae6d7124a54b04e4c5b7100430e
Autor:
Lewis Byrom, Jeff Jerman, Egle Gaurilcikaite, Alistair Mathie, Paul D. Wright, David McCoull, Jonathan M. Large, Barbara W. Hadrys, Yvonne Walsh, Emma L. Veale
Publikováno v:
Biochemical and Biophysical Research Communications. 520:35-40
TREK2 (KCNK10, K2P10.1) is a two-pore domain potassium (K2P) channel and a potential target for the treatment of pain. Like the majority of the K2P superfamily, there is currently a lack of useful pharmacological tools to study TREK2. Here we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162e9e2b1e010dc8a05809a0b03da63e
https://doi.org/10.1016/j.bbrc.2019.09.093
https://doi.org/10.1016/j.bbrc.2019.09.093
Autor:
Jeff Jerman, Catherine A. Kettleborough, Gregory Weir, David Tickle, Jamie Cartland, M. Zameel Cader, Paul D. Wright
TRESK is a two-pore domain potassium channel. Loss of function mutations have been linked to typical migraine with aura and due to TRESK's expression pattern and role in neuronal excitability it represents a promising therapeutic target. We developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033bb38dc5dc9bc13aee2a2c1356bc1b
https://doi.org/10.1016/j.bbrc.2013.10.090
https://doi.org/10.1016/j.bbrc.2013.10.090
Autor:
Edward G. McIver, Jeff Jerman, Nicholas Harries, Amanda E. Mackenzie, Graeme Milligan, Craig Southern, Debra L. Taylor, Zaynab Neetoo-Isseljee
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 344:568-578
Drugs targeting the orphan receptor GPR35 have potential therapeutic application in a number of disease areas, including inflammation, metabolic disorders, nociception, and cardiovascular disease. Currently available surrogate GPR35 agonists identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64acac71a63a98d498f42a5553dc04ad
https://doi.org/10.1124/jpet.112.201798
https://doi.org/10.1124/jpet.112.201798
Publikováno v:
Progress in molecular biology and translational science. 115
Label-free is a broad term used to describe a number of cutting-edge biosensor technologies that have attracted considerable attention in the area of drug discovery for seven-transmembrane G protein-coupled receptors (GPCRs). Label-free biosensors re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::867cd137e5813420804d06fcd7dc6e39
https://pubmed.ncbi.nlm.nih.gov/23415093
https://pubmed.ncbi.nlm.nih.gov/23415093
Publikováno v:
European journal of pharmacology. 314(3)
The novel compound SB 204269 ( trans -(+)-6-acetyl-4 S -(4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-2 H -benzo[ b ]pyran-3 R -ol,hemihydrate) shows potent anticonvulsant activity in the mouse maximal electroshock seizure threshold test. The bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6789ba4d7b8a232397dc6864810bcb9
https://pubmed.ncbi.nlm.nih.gov/8957267
https://pubmed.ncbi.nlm.nih.gov/8957267
Autor:
Marx, Vivien1
Publikováno v:
Nature Methods. Jan2014, Vol. 11 Issue 1, p33-38. 6p. 6 Color Photographs.