An Ethical Framework for Research Using Genetic Ancestry.

Autor: Lewis ACF, Molina SJ, Appelbaum PS, Dauda B, Fuentes A, Fullerton SM, Garrison NA, Ghosh N, Green RC, Hammonds EM, Jeff JM, Jones DS, Kenny EE, Kraft P, Mauro M, Ori APS, Panofsky A, Sohail M, Neale BM, Allen DS

Publikováno v: Perspectives in biology and medicine [Perspect Biol Med] 2023; Vol. 66 (2), pp. 225-248.

A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans.

Autor: Pendergrass SA; Genentech, Inc., South San Francisco, California, United States of America., Buyske S; Department of Statistics, Rutgers University, Piscataway, New Jersey, United States of America.; Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America., Jeff JM; Illumina, Inc., San Diego, California, United States of America., Frase A; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Dudek S; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Bradford Y; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Ambite JL; Information Sciences Institute; University of Southern California, Marina del Rey, California, United States of America., Avery CL; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America., Buzkova P; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Deelman E; Information Sciences Institute; University of Southern California, Marina del Rey, California, United States of America., Fesinmeyer MD; Amgen, Thousand Oaks, California, United States of America., Haiman C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America., Heiss G; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America., Hindorff LA; National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Hsu CN; Center for Research in Biological Systems, Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America., Jackson RD; The Ohio State University, Columbus, Ohio, United States of America., Lin Y; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America., Matise TC; Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America., Monroe KR; Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America., Moreland L; University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America., Park SL; Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America., Reiner A; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America., Wallace R; Departments of Epidemiology and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Ritchie MD; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Crawford DC; Cleveland Institute for Computational Biology, Cleveland, Ohio, United States of America.; Departments of Population and Quantitative Health Sciences and Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America.

Publikováno v: PloS one [PLoS One] 2019 Dec 31; Vol. 14 (12), pp. e0226771. Date of Electronic Publication: 2019 Dec 31 (Print Publication: 2019).

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.

Autor: Fernández-Rhodes L; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Malinowski JR; Write InSciTe, LLC, Hebron, Connecticut, United States of America., Wang Y; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America., Jeff JM; Genotyping Arrays Division, Illumina, Inc., San Diego, California, United States of America., Yoneyama S; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Carty CL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Setiawan VW; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America., Haiman C; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America., Corbett S; Kansas Health Institute, Topeka, Kansas, United States of America., Demerath E; Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America., Heiss G; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America., Buzkova P; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, United States of America., Crawford DC; Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America., Hunt SC; Department of Genetic Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar., Rao DC; Division of Biostatistics, Washington University in St. Louis, St. Louis, Michigan, United States of America., Schwander K; Division of Biostatistics, Washington University in St. Louis, St. Louis, Michigan, United States of America., Chakravarti A; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America., Gottesman O; Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Abul-Husn NS; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Raffel LJ; Division of Genetic and Genomic Medicine, University of California-Irvine, Irvine, California, United States of America., Yao J; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of America., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of America., Bielinski SJ; College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of America., Vaidya D; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America., Chen YI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, California, United States of America., Castañeda SF; South Bay Latino Research Center, Graduate School of Public Health, San Diego State University, San Diego, California, United States of America., Daviglus M; Institute of Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America., Talavera GA; South Bay Latino Research Center, Graduate School of Public Health, San Diego State University, San Diego, California, United States of America., Ryckman KK; Departments of Epidemiology and Pediatrics, University of Iowa, Iowa City, Iowa, United States of America., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Ambite JL; Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America., Buyske S; Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America., Hindorff L; Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Matise T; Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America., Franceschini N; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

Publikováno v: PloS one [PLoS One] 2018 Jul 25; Vol. 13 (7), pp. e0200486. Date of Electronic Publication: 2018 Jul 25 (Print Publication: 2018).

A multi-stage genome-wide association study of uterine fibroids in African Americans.

Autor: Hellwege JN; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA., Jeff JM; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wise LA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Slone Epidemiology Center at Boston University, Boston, MA, USA., Gallagher CS; Department of Genetics, Harvard Medical School, Boston, MA, USA., Wellons M; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA., Hartmann KE; Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA., Jones SF; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA., Torstenson ES; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Dickinson S; Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA., Ruiz-Narváez EA; Slone Epidemiology Center at Boston University, Boston, MA, USA., Rohland N; Department of Genetics, Harvard Medical School, Boston, MA, USA., Allen A; Department of Genetics, Harvard Medical School, Boston, MA, USA., Reich D; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tandon A; Department of Genetics, Harvard Medical School, Boston, MA, USA., Pasaniuc B; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Mancuso N; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Im HK; Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA., Hinds DA; 23andMe, Inc., Mountain View, CA, USA., Palmer JR; Slone Epidemiology Center at Boston University, Boston, MA, USA., Rosenberg L; Slone Epidemiology Center at Boston University, Boston, MA, USA., Denny JC; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Roden DM; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA., Stewart EA; Departments of Obstetrics and Gynecology and Surgery, Mayo Clinic and Mayo Clinic School of Medicine, Rochester, MN, USA., Morton CC; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; University of Manchester Academic Health Science Centre, Manchester, England, UK.; Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kenny EE; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA., Velez Edwards DR; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. digna.r.velez.edwards@vanderbilt.edu.; Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. digna.r.velez.edwards@vanderbilt.edu.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA. digna.r.velez.edwards@vanderbilt.edu.

Publikováno v: Human genetics [Hum Genet] 2017 Oct; Vol. 136 (10), pp. 1363-1373. Date of Electronic Publication: 2017 Aug 23.

Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.

Autor: Avery CL; Department of Epidemiology; Carolina Population Center. Electronic address: christy_avery@unc.edu., Wassel CL; Department of Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, Vermont., Richard MA; Institute of Molecular Medicine and; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas., Highland HM; Department of Epidemiology., Bien S; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Zubair N; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Soliman EZ; Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center and; Department of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston Salem, North Carolina., Fornage M; Institute of Molecular Medicine and; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas., Bielinski SJ; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota., Tao R; Department of Biostatistics., Seyerle AA; Department of Epidemiology., Shah SJ; Department of Preventive Medicine and; Department of Medicine, Northwestern University Feinberg School of Medicine and., Lloyd-Jones DM; Department of Preventive Medicine and; Department of Medicine, Northwestern University Feinberg School of Medicine and., Buyske S; Department of Statistics and Biostatistics and; Department of Genetics, Rutgers University, Piscataway, New Jersey., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California., Post WS; Department of Medicine and; Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia., Hindorff LA; National Institutes of Health, National Human Genome Research Institute, Office of Population Genomics, Bethesda, Maryland., Jeff JM; Genetics and Genomic Sciences, The Charles Bronfman Institute for Personalized Medicine, The Center for Statistical Genetics, and The Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York., Shohet RV; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington., Lin DY; Department of Biostatistics., Whitsel EA; Department of Epidemiology; Department of Medicine., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Haiman CA; Department of Preventive Medicine, Keck School of Medicine and; Norris Comprehensive Cancer Center, University of Southern California, Pasadena, California., Crawford DC; Department of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., North KE; Department of Epidemiology; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Publikováno v: Heart rhythm [Heart Rhythm] 2017 Apr; Vol. 14 (4), pp. 572-580. Date of Electronic Publication: 2016 Dec 14.