Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeff Hewitt"'
Publikováno v:
Biotechnology and Bioengineering. 102:644-650
During mineral processing, concentrates of sulfide minerals of economic interest are formed by froth flotation of fine ore particles. The method works well but recovery and selectivity can be poor for ores with complex mineralogy. There is considerab
Autor:
Hélène C. F. Côté, Yili Wang, Ross T. A. MacGillivray, Stephen G. Withers, Jeff Hewitt, Shin Numao, Hung C. Vo, Gary D. Brayer, Gary Sidhu, Edwin H. Rydberg, Christopher M. Overall
Publikováno v:
Protein Science. 8:635-643
Human pancreatic alpha-amylase (HPA) was expressed in the methylotrophic yeast Pichia pastoris and two mutants (D197A and D197N) of a completely conserved active site carboxylic acid were generated. All recombinant proteins were shown by electrospray
Autor:
Mark R. Bleackley, Valerie C. Smith, Jennifer N. M. Ballard, Ross T. A. MacGillivray, Jeff Hewitt, John K. Wu, David G. Huntsman, S. Craven, Frederick A. Ofosu, Louis D. Wadsworth, Lindsay Brown
Publikováno v:
British Journal of Haematology. 140:589-592
Publikováno v:
Biochemistry. 42:9060-9066
Streptomyces griseus trypsin (SGT) was chosen as a model scaffold for the development of serine proteases with enhanced substrate specificity. Recombinant SGT has been produced in a Bacillus subtilis expression system in a soluble active form and pur
Autor:
Valerie C. Smith, Peter J. Halbrooks, Qing-Yu He, Dmitry R. Gumerov, Jeff Hewitt, Anne B. Mason, Ross T. A. MacGillivray, Igor A. Kaltashov, Stephen J. Everse
Publikováno v:
Biochemistry. 41:9448-9454
Attachment of a cleavable hexa His tag is a common strategy for the production of recombinant proteins. Production of two recombinant nonglycosylated human serum transferrins (hTF-NG), containing a factor Xa cleavage site and a hexa His tag at the ca
Autor:
Jeff Hewitt, Jina Song, Edward L.G. Pryzdial, Michael Ho, Kimberley Talbot, Cedric J. Carter, Katherine Serrano, Ross T. A. MacGillivray
Publikováno v:
British Journal of Haematology. 151:198-200
Regulation of granuloma formation via Myd88 and Nox2 in a model of pulmonary sarcoidosis (MPF5P.741)
Publikováno v:
The Journal of Immunology. 194:137.4-137.4
Sarcoidosis is characterized by non-caseating granulomas with an unknown etiology that present primarily in the lung. Propionibacterium acnes, an immunogenic commensal skin bacterium involved in acne vulgaris, has been implicated as a causative agent
Autor:
Karen C. Ung, Sara K. Briggs, Vinh Nguyen, Anne B. Mason, Evelyn M. Teh, Tanya A. M. Griffiths, Jeff Hewitt, Ross T. A. MacGillivray
Publikováno v:
The FEBS journal. 272(24)
The molecular basis of the transferrin (TF)–transferrin receptor (TFR) interaction is not known. The C-lobe of TF is required to facilitate binding to the TFR and both the N- and C-lobes are necessary for maximal binding. Several mAb have been rais
Autor:
Timothy J. Kieffer, Phil J. Schieldrop, Raymond A. Pederson, Jeff Hewitt, Ruan Elliot, Richard W. Gelling, Christopher H.S. McIntosh
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1308:111-113
A 537 base pair cDNA clone for murine GIP has been isolated. The elucidated sequence encodes an open reading frame of 432 base pairs which codes for a 144 amino acid precursor. Murine GIP is predicted to differ from the human hormone by three amino a
Autor:
Jeff Hewitt, Alison M.J. Buchan, York N. Hsiang, Susan B. Curtis, Svetlana Yakubovitz, Alexander Anzarut
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 278(6)
In animal models the somatostatin analog angiopeptin inhibits intimal hyperplasia by acting primarily through somatostatin receptor 2 (SSTR-2). However, the results of clinical trials using angiopeptin have been disappointing. In this study we showed