Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations

Autor: Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg

Publikováno v: Epigenetics, Vol 19, Iss 1 (2024)

ABSTRACTSystemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understoo

Externí odkaz: https://doaj.org/article/f6942193d47e4a7095b9b17d360571e0

Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans.

Autor: Nora Franceschini, Cara L Carty, Yingchang Lu, Ran Tao, Yun Ju Sung, Ani Manichaikul, Jeff Haessler, Myriam Fornage, Karen Schwander, Niha Zubair, Stephanie Bien, Lucia A Hindorff, Xiuqing Guo, Suzette J Bielinski, Georg Ehret, Joel D Kaufman, Stephen S Rich, Christopher S Carlson, Erwin P Bottinger, Kari E North, D C Rao, Aravinda Chakravarti, Paula Q Barrett, Ruth J F Loos, Steven Buyske, Charles Kooperberg

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164132 (2016)

Despite the substantial burden of hypertension in US minority populations, few genetic studies of blood pressure have been conducted in Hispanics and African Americans, and it is unclear whether many of the established loci identified in European-des

Externí odkaz: https://doaj.org/article/ead936d61b134f7dbf03af417585a1d8

Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.

Autor: Logan Dumitrescu, Cara L Carty, Kira Taylor, Fredrick R Schumacher, Lucia A Hindorff, José L Ambite, Garnet Anderson, Lyle G Best, Kristin Brown-Gentry, Petra Bůžková, Christopher S Carlson, Barbara Cochran, Shelley A Cole, Richard B Devereux, Dave Duggan, Charles B Eaton, Myriam Fornage, Nora Franceschini, Jeff Haessler, Barbara V Howard, Karen C Johnson, Sandra Laston, Laurence N Kolonel, Elisa T Lee, Jean W MacCluer, Teri A Manolio, Sarah A Pendergrass, Miguel Quibrera, Ralph V Shohet, Lynne R Wilkens, Christopher A Haiman, Loïc Le Marchand, Steven Buyske, Charles Kooperberg, Kari E North, Dana C Crawford

Publikováno v: PLoS Genetics, Vol 7, Iss 6, p e1002138 (2011)

For the past five years, genome-wide association studies (GWAS) have identified hundreds of common variants associated with human diseases and traits, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)

Externí odkaz: https://doaj.org/article/68c7d03785fd492ab45f2b112beb3801

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

Autor: Priyadarshini Kachroo, Julian Hecker, Bo L. Chawes, Tarunveer S. Ahluwalia, Michael H. Cho, Dandi Qiao, Rachel S. Kelly, Su H. Chu, Yamini V. Virkud, Mengna Huang, Kathleen C. Barnes, Esteban G. Burchard, Celeste Eng, Donglei Hu, Juan C. Celedón, Michelle Daya, Albert M. Levin, Hongsheng Gui, L. Keoki Williams, Erick Forno, Angel C.Y. Mak, Lydiana Avila, Manuel E. Soto-Quiros, Michelle M. Cloutier, Edna Acosta-Pérez, Glorisa Canino, Klaus Bønnelykke, Hans Bisgaard, Benjamin A. Raby, Christoph Lange, Scott T. Weiss, Jessica A. Lasky-Su, Namiko Abe, Goncalo Abecasis, Christine Albert, Nicholette (Nichole) Palmer Allred, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Dan Arking, Donna K. Arnett, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, John Barnard, Kathleen Barnes, R. Graham Barr, Emily Barron-Casella, Terri Beaty, Diane Becker, Lewis Becker, Rebecca Beer, Ferdouse Begum, Amber Beitelshees, Emelia Benjamin, Marcos Bezerra, Larry Bielak, Joshua Bis, Thomas Blackwell, John Blangero, Eric Boerwinkle, Ingrid Borecki, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Jai Broome, Karen Bunting, Esteban Burchard, Jonathan Cardwell, Cara Carty, Richard Casaburi, James Casella, Mark Chaffin, Christy Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Yii-Der Ida Chen, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Elaine Cornell, Adolfo Correa, Carolyn Crandall, James Crapo, L. Adrienne Cupples, Joanne Curran, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Sayantan Das, Sean David, Colleen Davis, Mariza de Andrade, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Ron Do, Qing Duan, Ravi Duggirala, Peter Durda, Susan Dutcher, Charles Eaton, Lynette Ekunwe, Patrick Ellinor, Leslie Emery, Charles Farber, Leanna Farnam, Tasha Fingerlin, Matthew Flickinger, Myriam Fornage, Nora Franceschini, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Yan Gao, Margery Gass, Bruce Gelb, Xiaoqi (Priscilla) Geng, Soren Germer, Chris Gignoux, Mark Gladwin, David Glahn, Stephanie Gogarten, Da-Wei Gong, Harald Goring, C. Charles Gu, Yue Guan, Xiuqing Guo, Jeff Haessler, Michael Hall, Daniel Harris, Nicola Hawley, Jiang He, Ben Heavner, Susan Heckbert, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, John Hokanson, Kramer Holly, Elliott Hong, Karin Hoth, Chao (Agnes) Hsiung, Haley Huston, Chii Min Hwu, Marguerite Ryan Irvin, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Min A. Jhun, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Robert Kaplan, Sharon Kardia, Sekar Kathiresan, Laura Kaufman, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Greg Kinney, Barbara Konkle, Charles Kooperberg, Stephanie Krauter, Ethan Lange, Leslie Lange, Cathy Laurie, Cecelia Laurie, Meryl LeBoff, Seunggeun Shawn Lee, Wen-Jane Lee, Jonathon LeFaive, David Levine, Dan Levy, Joshua Lewis, Yun Li, Honghuang Lin, Keng Han Lin, Simin Liu, Yongmei Liu, Ruth Loos, Steven Lubitz, Kathryn Lunetta, James Luo, Michael Mahaney, Barry Make, Ani Manichaikul, JoAnn Manson, Lauren Margolin, Lisa Martin, Susan Mathai, Rasika Mathias, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Stephen McGarvey, Hao Mei, Deborah A. Meyers, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L. Minster, Braxton Mitchell, May E. Montasser, Solomon Musani, Stanford Mwasongwe, Josyf C. Mychaleckyj, Girish Nadkarni, Rakhi Naik, Pradeep Natarajan, Sergei Nekhai, Deborah Nickerson, Kari North, Jeff O'Connell, Tim O'Connor, Heather Ochs-Balcom, James Pankow, George Papanicolaou, Margaret Parker, Afshin Parsa, Sara Penchev, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S. Phillips, Sam Phillips, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Dmitry Prokopenko, Bruce Psaty, Pankaj Qasba, Zhaohui Qin, Nicholas Rafaels, Laura Raffield, Vasan Ramachandran, D.C. Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Susan Redline, Robert Reed, Elizabeth Regan, Alex Reiner, Ken Rice, Stephen Rich, Dan Roden, Carolina Roselli, Jerome Rotter, Ingo Ruczinski, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Phuwanat Sakornsakolpat, Shabnam Salimi, Steven Salzberg, Kevin Sandow, Vijay Sankaran, Christopher Scheller, Ellen Schmidt, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Vivien Sheehan, Amol Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, M. Benjamin Shoemaker, Brian Silver, Edwin Silverman, Jennifer Smith, Josh Smith, Nicholas Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Tamar Sofer, Nona Sotoodehnia, Adrienne Stilp, Elizabeth Streeten, Yun Ju Sung, Jessica Su-Lasky, Jody Sylvia, Adam Szpiro, Carole Sztalryd, Daniel Taliun, Hua Tang, Margaret Taub, Kent Taylor, Simeon Taylor, Marilyn Telen, Timothy A. Thornton, Lesley Tinker, David Tirschwell, Hemant Tiwari, Russell Tracy, Michael Tsai, Dhananjay Vaidya, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Emily Wan, Fei Fei Wang, Karol Watson, Daniel E. Weeks, Bruce Weir, Scott Weiss, Lu-Chen Weng, Cristen Willer, Kayleen Williams, Carla Wilson, James Wilson, Quenna Wong, Huichun Xu, Lisa Yanek, Ivana Yang, Rongze Yang, Norann Zaghloul, Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Xiuwen Zheng, Degui Zhi, Xiang Zhou, Michael Zody, Sebastian Zoellner

Publikováno v: Chest

BACKGROUND: Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa84f9efcadaac878e96bdde5e95ac4
https://doi.org/10.1016/j.chest.2019.08.2202

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Autor: Michael Boehnke, Anke R. Hammerschlag, Stavroula Kanoni, Nilesh J. Samani, Stefan Blankenberg, Arpana Agrawal, Ersin Yavas, Chris Hsu, Dominique Arveiler, Giovanni Veronesi, Sarah E. Harris, Guillaume Lettre, Leah Wetherill, Helen R. Warren, M Samuel, Manav Kapoor, Praveen Surendran, Mengzhen Liu, Massimo Mangino, Abdulla Al Shafi Majumder, Chiara Batini, Jeff Haessler, Anton J. M. De Craen, Matt McGue, Laura J. Bierut, Yi Ling Chou, Markku Laakso, Ian J. Deary, Rebecca Rohde, Nhung Le, David Schlessinger, J. Dylan Weissenkampen, Claudia Langenberg, Tim D. Spector, Paul W. Franks, John P. Rice, Philippe M. Frossard, Hanieh Yaghootkar, Janie Corley, Frank Kee, J. Wouter Jukema, Pim van der Harst, Dermot F. Reily, Jenny Chang-Claude, Nicholas G. Martin, Tatiana Foroud, Sune F. Nielsen, Charles Kooperberg, Rudolf A. de Boer, Francesco Cucca, Paul D.P. Pharoah, Alex P. Reiner, Daniel R. Barnes, Anders Mälarstig, Jonathan Marten, Henry Völzke, Yu Jiang, Jukka Kontto, J Danesh, Antonis C. Antoniou, Andrew C. Heath, Nicholas J. Wareham, Joanna M. M. Howson, Alison Goate, Olov Rolandsson, Frida Renström, Chu Chen, Vinicius Tragante, Matt J. Neville, Kathleen Stirrups, Clemens Baumbach, Colin N. A. Palmer, Adam S. Butterworth, William G. Iacono, Naveed Sattar, Ian P. Hall, Daniel O. Stram, Giorgio Pistis, Jan-Håkan Jansson, Jaakko Kaprio, David R. Weir, David P. Strachan, Martin D. Tobin, Folkert W. Asselbergs, John M. Starr, Stefan Weiss, Thomas F. Vogt, Riccardo E. Marioni, Maarten Hoek, Jessica Tyrrell, Hilary A. Tindle, Alison M. Dunning, Anu Loukola, Joe Dennis, Victoria E. Jackson, Louise V. Wain, Eleftheria Zeggini, Weihua Zhang, Yaming Shao, Kari Kuulasmaa, Elisabeth Altmaier, Jean-Claude Tardif, Jian Gong, A. Mesut Erzurumluoglu, Andries R. van der Leij, Kari E. North, Anna F. Dominiczak, Martina Müller-Nurasyid, Scott I. Vrieze, Sarah Bertelsen, Markus Perola, Evangelos Evangelou, Chris J. Packard, Gonçalo R. Abecasis, Robert A. Scott, S. Trompet, Jennifer A. Smith, H. Steven Scholte, Timothy M. Frayling, Danielle Posthuma, Ian Ford, Douglas F. Easton, Børge Grønne Nordestgaard, Michiel L. Bots, Charles B. Eaton, Sharon L.R. Kardia, Dewan S. Alam, Xiaowei Zhan, Sean P. David, Maria Uria-Nickelsen, Dongbing Lai, Ilonca Vaartjes, Mark J. Caulfield, Valérie Turcot, Jean Ferrières, Emanuele Di Angelantonio, Robin Young, Pamela A. F. Madden, Tibor V. Varga, Asif Rasheed, Peter van der Meer, Dajiang J. Liu, Ioanna Tachmazidou, Panos Deloukas, Danish Saleheen, Evelin Mihailov, Caroline Hayward, Patricia B. Munroe, Beenish Qaiser, Jessica D. Faul, John C. Chambers, Matthias Nauck, Niek Verweij, Jordan M. Hughey, Christopher A. Haiman, Hans J. Grabe, Muriel Caslake, Saima Afaq, Jaspal S. Kooner, Tinca J. C. Polderman, Philippe Amouyel, Wei Zhao, Göran Hallmans, Andres Metspalu, Jarmo Virtamo, Carl A. Melbourne, Kaixin Zhou, Christiaan de Leeuw, Peter S. Sever, Eirini Marouli, Neil Poulter, Rajiv Chowdhury, Jian'an Luan, Deborah J. Thompson, F Karpe, Kyriaki Michailidou, David M. Brazel, Heather M. Stringham

Publikováno v: Biological Psychiatry, 85(11), 946-955. Elsevier
Biological Psychiatry, 85(11), 946-955. Elsevier USA
Biological Psychiatry, 85(11), 946-955. ELSEVIER SCIENCE INC
Brazel, D M, Jiang, Y, Hughey, J M, Turcot, V, Zhan, X, Gong, J, Batini, C, Weissenkampen, J D, Liu, M, Barnes, D R, Bertelsen, S, Chou, Y-L, Erzurumluoglu, A M, Faul, J D, Haessler, J, Hammerschlag, A R, Hsu, C, Kapoor, M, Lai, D, Le, N, de Leeuw, C A, Loukola, A, Mangino, M, Melbourne, C A, Pistis, G, Qaiser, B, Rohde, R, Shao, Y, Stringham, H, Wetherill, L, Zhao, W, Agrawal, A, Bierut, L, Chen, C, Eaton, C B, Goate, A, Haiman, C, Heath, A, Iacono, W G, Martin, N G, Polderman, T J, Reiner, A, Rice, J, Schlessinger, D, Scholte, H S, Smith, J A, Tardif, J-C, Tindle, H A, van der Leij, A R, Boehnke, M, Chang-Claude, J, Cucca, F, David, S P, Foroud, T, Howson, J M M, Kardia, S L R, Kooperberg, C, Laakso, M, Lettre, G, Madden, P, Mcgue, M, North, K, Posthuma, D, Spector, T, Stram, D, Tobin, M D, Weir, D R, Kaprio, J, Abecasis, G R, Liu, D J, Vrieze, S, Surendran, P, Young, R, Barnes, D R, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Kontto, J, Perola, M, Caslake, M, de Craen, A J M, Trompet, S, Uria-Nickelsen, M, Malarstig, A, Reily, D F, Hoek, M, Vogt, T, Jukema, J W, Sattar, N, Ford, I, Packard, C J, Alam, D S, Majumder, A A S, Di Ange-Lantonio, E, Chowdhury, R, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrieres, J, Kee, F, Kuulasmaa, K, Mueller-Nurasyid, M, Veronesi, G, Virtamo, J, Frossard, P, Nordestgaard, B G, Saleheen, D, Danesh, J, Butterworth, A S, Howson, J M M, Erzurumluoglu, A M, Jackson, V E, Melbourne, C A, Varga, T V, Warren, H R, Tragante, V, Tachmazidou, I, Harris, S E, Evangelou, E, Marten, J, Zhang, W, Altmaier, E, Luan, J, Langenberg, C, Scott, R A, Yaghootkar, H, Stirrups, K, Kanoni, S, Marouli, E, Karpe, F, Dominiczak, A F, Sever, P, Poulter, N, Rolandsson, O, Baumbach, C, Afaq, S, Chambers, J C, Kooner, J S, Wareham, N J, Renstrom, F, Hallmans, G, Marioni, R E, Corley, J, Starr, J M, Verweij, N, de Boer, R A, van der Meer, P, Yavas, E, Vaartjes, I, Bots, M L, Asselbergs, F W, Grabe, H J, Volzke, H, Nauck, M, Weiss, S, Pharoah, P D P, Dunning, A M, Dennis, J G, Thompson, D J, Michailidou, K, Easton, D F, Antoniou, A C, Tyrrell, J, Mihailov, E, Samani, N J, Zhou, K, Neville, M J, Metspalu, A, Palmer, C N A, Hall, I P, Strachan, D P, Deary, I J, Frayling, T M, Hayward, C, van der Harst, P, Zeggini, E, Munroe, P B, Jansson, J-H, Franks, P W, Deloukas, P, Caulfield, M J, Wain, L V & Tobin, M D 2019, ' Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use ', Biological Psychiatry, vol. 85, no. 11, pp. 946-955 . https://doi.org/10.1016/j.biopsych.2018.11.024
Biological Psychiatry, 85(11), 946. Elsevier USA
Brazel, D M, Jiang, Y, Hughey, J M, Turcot, V, Zhan, X, Gong, J, Batini, C, Weissenkampen, J D, Liu, M, Surendran, P, Young, R, Barnes, D R, Nielsen, S F, Rasheed, A, Samuel, M, Zhao, W, Kontto, J, Perola, M, Caslake, M, de Craen, A J M, Trompet, S, Uria-Nickelsen, M, Malarstig, A, Reily, D F, Hoek, M, Vogt, T, Jukema, J W, Sattar, N, Ford, I, Packard, C J, Alam, D S, Majumder, A A S, di Angelantonio, E, Chowdhury, R, Amouyel, P, Arveiler, D, Blankenberg, S, Ferrières, J, Kee, F, Kuulasmaa, K, Müller-Nurasyid, M, Veronesi, G, Virtamo, J, EPIC-CVD Consortium, Frossard, P, Nordestgaard, B R G, Saleheen, D, Danesh, J, Hammerschlag, A R, Posthuma, D, Spector, T, Stram, D O, Tobin, M D, Weir, D R, Kaprio, J, Abecasis, G R, Liu, D J, Vrieze, S & CHD Exome+ Consortium 2019, ' Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use ', Biological Psychiatry, vol. 85, no. 11, pp. 946-955 . https://doi.org/10.1016/j.biopsych.2018.11.024
Biological psychiatry. Elsevier USA
CHD Exome+ Consortium & Consortium for Genetics of Smoking Behaviour 2019, ' Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use ', Biological Psychiatry, vol. 85, no. 11, pp. 946-955 . https://doi.org/10.1016/j.biopsych.2018.11.024

BackgroundSmoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification of biological mechanisms in substance use. Exome arrays and genotype imputation c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4c6686918e3fb0cec91a0a7423b4f4
https://dare.uva.nl/personal/pure/en/publications/exome-chip-metaanalysis-fine-maps-causal-variants-and-elucidates-the-genetic-architecture-of-rare-coding-variants-in-smoking-and-alcohol-use(5b2dcbfd-0c32-47f3-869f-1ff60f676314).html