Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jeff Edwards"'
Autor:
Antony J. Williams, Christopher M. Grulke, Jeff Edwards, Andrew D. McEachran, Kamel Mansouri, Nancy C. Baker, Grace Patlewicz, Imran Shah, John F. Wambaugh, Richard S. Judson, Ann M. Richard
Publikováno v:
Journal of Cheminformatics, Vol 9, Iss 1, Pp 1-27 (2017)
Abstract Despite an abundance of online databases providing access to chemical data, there is increasing demand for high-quality, structure-curated, open data to meet the various needs of the environmental sciences and computational toxicology commun
Externí odkaz:
https://doaj.org/article/423d135086a14b02a4ab55d0ce71708f
Autor:
Lisa Long, Rahul Javaji, Will Nelson, Jeff Edwards, Paul Ziade, Chris Morton, Craig T. Johansen
Publikováno v:
AIAA AVIATION 2022 Forum.
Autor:
Jill Summers, Tony Wright, Heather Benson, Penny Moss, George Tsadilas, Jeff Edwards, Rob Will
Publikováno v:
Rheumatology. 61
Background/Aims Treatment of knee osteoarthritis (OA) focuses on reducing pain and improving function. Transdermal NSAID formulations have been developed as an alternative approach to reduce pain and sensitisation around the OA affected joint whilst
Publikováno v:
ALTEX.
Generalized Read-Across (GenRA) is a data driven approach which makes read-across predictions on the basis of a similarity weighted activity of source analogues (nearest neighbors). GenRA has been described in more detail in the literature (Shah et a
Autor:
Jeff Edwards
Throughout the ages the possession of an unremarkable sword has seemingly been the magic that allowed dynasties to flourish. When a modern tyrant seeks to find the sword and use its power, The Fund find themselves in a race to locate this treasure an
Autor:
William McDowell, Julia Swierkosz, George Badescu, Andrew F. Kyle, Mark Frigerio, Amrita Abhilash, Ji-Won Choi, Estera Jamieson, Matthew P. Baker, XiaoBo Sheng, Matthew Bird, Penny Bryant, Ruslan Grygorash, Katarzyna Kozakowska, Korinna Henseleit, Rita Tommasi, Vimal Parekh, Kosma Jurlewicz, Karolina Peciak, Emmanuelle Laurine, Martin Pabst, Nicolas Camper, Antony Godwin, Anaïs Manin, Jeff Edwards, David Morris
Publikováno v:
Molecular Pharmaceutics. 12:1872-1879
The conjugation of monomethyl auristatin E (MMAE) to trastuzumab using a reduction bis-alkylation approach that is capable of rebridging reduced (native) antibody interchain disulfide bonds has been previously shown to produce a homogeneous and stabl
Autor:
Hussien A. Al-Shamma, Michael Morgan, Ibragim Gaidarov, Huong T. Dang, Joel Gatlin, Marc Decaire, David J. Unett, Karoline Choi, Jeff Edwards, Dawei Yue, Abu J.M. Sadeque, Kevin Whelan, Yifeng Xiong, Lixia Fu, Jayant Thatte, Graeme Semple, Sonja Strah-Pleynet, Sangdon Han, Michelle Solomon, Dominic P. Behan, Jae-Kyu Jung, Sanju Narayanan, Lars Thoresen, Robert M. Jones, Chuan Chen, Xiuwen Zhu, Khawja A. Usmani, Cameron Pride, Ruoping Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:322-326
The design and synthesis of novel 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamide CB2 selective ligands for the potential treatment of pain is described. Compound (R,R)-25 has good balance between CB2 agonist potency and selecti
Autor:
Ben Johnson, Tawfik Gharbaoui, Moody Jeanne, David J. Unett, Kevin Whelan, Ibragim Gaidarov, Michael Morgan, Lars Thoresen, Michelle Kasem, Abu J.M. Sadeque, Robert M. Jones, Chuan Chen, Sun Hee Kim, Hussien A. Al-Shamma, Minh Le, Joel Gatlin, Lorene Calvano, Andrew M. Kawasaki, Lixia Fu, Yinghong Gao, Scott Stirn, Weichao Chen, Jeremy Barden, Dominic P. Behan, Krishnan Ashwin M, Xiuwen Zhu, Graeme Semple, Dipanjan Sengupta, Christopher Ronald J, Jeff Edwards, Luis Lopez, Jayant Thatte, Daniel J. Buzard, Anthony C. Blackburn, Michelle Solomon, Todd Anthony, Thomas O. Schrader, Khawja A. Usmani
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1334-1339
S1P1 is a validated target for treatment of autoimmune disease, and functional antagonists with superior safety and pharmacokinetic properties are being sought as second generation therapeutics. We describe the discovery and optimization of (7-benzyl
Autor:
Weichao Chen, Andrew M. Kawasaki, Dominic P. Behan, Jeff Edwards, You-An Ma, Tawfik Gharbaoui, Sun Hee Kim, Jayant Thatte, Hussien A. Al-Shamma, Carleton R. Sage, Jeremy Barden, Anthony C. Blackburn, Michelle Solomon, Xiuwen Zhu, Christopher Ronald J, David Mills, Ibragim Gaidarov, Antonio Garrido Montalban, Sangdon Han, Luis Lopez, Dipanjan Sengupta, Michael Morgan, Juerg Lehmann, Daniel J. Buzard, Graeme Semple, Kevin Whelan, Yinghong Gao, Joel Gatlin, Moody Jeanne, David J. Unett, Imelda Calderon, Lars Thoresen, Robert M. Jones, Brett Ullman, Todd Anthony, Chuan Chen, Minh Le, Khawja A. Usmani, Scott Stirn, Jaimie Karyn Rueter, Lixia Fu, Lorene Calvano, Abu J.M. Sadeque
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1313-1317
APD334 was discovered as part of our internal effort to identify potent, centrally available, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases. APD3
Autor:
Jeff Edwards
Genocide in the African country of Sontaria causes a surge of escaping refugees to seek sanctuary in neighbouring Namola.In Namola, The Fund uses all its resources to build a state-of-the-art facility and to move the refugees from their disease ridde