Výsledky vyhledávání - "Jeff E. Frediani"

An improved synthesis of oligodeoxynucleotide N3'->P5' phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification

Autor: Jeffrey S. Nelson, Karen L. Fearon, Annette M. Raible, Vicky Boyd, Michael F. Foy, Andrzej Okruszek, Jeff E. Frediani, Lawrence A. DeDionisio, Sarah N. McCurdy, Mark Q. Nguyen, E. Neil Cagle, Bernard L. Hirschbein

Publikováno v: Nucleic Acids Research. 26:3813-3824

Oligodeoxynucleotide N3'-->P5' phosphoramidates are promising candidates for antisense therapeutics, as well as for diagnostic applications. We recently reported a new method for the synthesis of these oligonucleotide analogs which makes use of a pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe81ede51584566783eab06febd86a2
https://doi.org/10.1093/nar/26.16.3813

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N3'--P5' Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction

Autor: Jeff E. Frediani, Jeffrey S. Nelson, Mark Q. Nguyen, Michael F. Foy, Karen L. Fearon, Sarah N. McCurdy, Bernard L. Hirschbein

Publikováno v: The Journal of organic chemistry. 62(21)

A new method for the synthesis of N3'--P5' phosphoramidate oligodeoxynucleotides is demonstrated. Described herein is the synthesis of the monomers utilized in the phosphoramidite amine-exchange process and the experimental details pertaining to this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c41c843c0e73ed79f3ec907db1c7e8
https://pubmed.ncbi.nlm.nih.gov/11671841

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