Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy

Autor: Jeff E. Angermann, Tong Zhou, Leah E. Burnett, Abigail Bender, Yi Shen, Bradley S. Ferguson, Levi W. Evans, Dante Staten, Luis D. Godoy

Publikováno v: J Nutr Biochem

Pathological cardiac hypertrophy is a classical hallmark of heart failure. At the molecular level, inhibition of histone deacetylase (HDAC) enzymes attenuate pathological cardiac hypertrophy in vitro and in vivo. Emodin is an anthraquinone that has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423a7be9f889169c891b61916bad6037
https://doi.org/10.1016/j.jnutbio.2019.108339

Arsenic Methylation Capacity and Metabolic Syndrome in the 2013-2014 U.S. National Health and Nutrition Examination Survey (NHANES)

Autor: Clare Pace, Julie Smith-Gagen, Jeff E. Angermann

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health; Volume 15; Issue 1; Pages: 168
International Journal of Environmental Research and Public Health, Vol 15, Iss 1, p 168 (2018)

Arsenic methylation capacity is associated with metabolic syndrome and its components among highly exposed populations. However, this association has not been investigated in low to moderately exposed populations. Therefore, we investigated arsenic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e39fd92258a63f82d10656c58bf723
https://pubmed.ncbi.nlm.nih.gov/29361794

Monomethylarsonous Acid, But Not Inorganic Arsenic, is a Mitochondria-Specific Toxicant in Vascular Smooth Muscle Cells

Autor: Tania Das Banerjee, Ruben K. Dagda, Barrett M. Welch, Roxana Khalili, Jeff E. Angermann, Clare Pace

Arsenic exposure has been implicated as a risk factor for cardiovascular diseases, metabolic disorders, and cancer, yet the role mitochondrial dysfunction plays in the cellular mechanisms of pathology is largely unknown. To investigate arsenic-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958da2497e892b6214118c6177d0e49a
https://europepmc.org/articles/PMC4938733/

Enhanced capacitative calcium entry and sarcoplasmic-reticulum calcium storage capacity with advanced age in murine mesenteric arterial smooth muscle cells

Autor: Sean M. Wilson, John N. Buchholz, Jeff E. Angermann, Olga Ostrovskaya, Gregory D. Smith, Ravi Goyal

Publikováno v: Experimental Gerontology. 44:201-207

Intracellular Ca 2+ signaling is important to perfusion pressure related arterial reactivity and to vascular disorders including hypertension, angina and ischemic stroke. We have recently shown that advancing-age leads to calcium signaling adaptation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dbe7c63db1a8aa9f81dfea90efe933
https://doi.org/10.1016/j.exger.2008.10.007

Mechanism of the Inhibition of Ca2+-Activated Cl− Currents by Phosphorylation in Pulmonary Arterial Smooth Muscle Cells

Autor: Jeff E. Angermann, Normand Leblanc, James L. Kenyon, Amy R. Sanguinetti, Iain A. Greenwood

Publikováno v: The Journal of General Physiology

The aim of the present study was to provide a mechanistic insight into how phosphatase activity influences calcium-activated chloride channels in rabbit pulmonary artery myocytes. Calcium-dependent Cl- currents (I(ClCa)) were evoked by pipette soluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2f5aaa377a1e9fe02274d79ce93e6b
https://doi.org/10.1085/jgp.200609507