Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jeff D. Colbert"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface. This allows CD8 T cells to identify pathological cells that are synt
Externí odkaz:
https://doaj.org/article/3f652a5bfbb04887a7bb8d6c894cf43e
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(42)
MHC molecules are not randomly distributed on the plasma membrane but instead are present in discrete nanoclusters. The mechanisms that control formation of MHC I nanoclusters and the importance of such structures are incompletely understood. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2874d1836ef5195201397213ded8d59d
https://pubmed.ncbi.nlm.nih.gov/36215490
https://pubmed.ncbi.nlm.nih.gov/36215490
Publikováno v:
Curr Opin Immunol
In order to get recognized by CD8 T cells, most cells present peptides from endogenously expressed self or foreign proteins on MHC class I molecules. However, specialized antigen-presenting cells, such as DCs and macrophages, can present exogenous an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d3ac5c2ceb0d3a824cc52994aadd61
https://doi.org/10.1016/j.coi.2019.12.005
https://doi.org/10.1016/j.coi.2019.12.005
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface. This allows CD8 T cells to identify pathological cells that are synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb0ba43391caea6e96919894152100a
https://www.frontiersin.org/articles/10.3389/fimmu.2021.636568/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.636568/full
Publikováno v:
EMBO J
For CD8 T lymphocytes to mount responses to cancer and virally-infected cells, dendritic cells must capture antigens present in tissues and display them as peptides bound to MHC-I molecules. This is most often accomplished through a pathway called an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff21141f802d61af7ea58cfd733375a
https://europepmc.org/articles/PMC6960445/
https://europepmc.org/articles/PMC6960445/
The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules
Publikováno v:
Annual Review of Immunology. 35:149-176
To monitor the health of cells, the immune system tasks antigen-presenting cells with gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides bound to MHC-I molecules. Most cells would be unable to perform this fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f80e0e5b8bb0a75dc094fcc392c2665
https://doi.org/10.1146/annurev-immunol-041015-055254
https://doi.org/10.1146/annurev-immunol-041015-055254
Autor:
Kenneth L. Rock, Jeff D. Colbert
Publikováno v:
J Biol Chem
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims antigenic peptide precursors to generate mature antigenic peptides for presentation by major histocompatibility complex class I (MHCI) molecules and regulates adaptive immune responses. ERAP1 has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf42f872c99fb167a522b18d895de86
https://doi.org/10.1074/jbc.h120.013868
https://doi.org/10.1074/jbc.h120.013868
Autor:
Hiroshi Kataoka, Jeff D. Colbert, Matthew Bogyo, Gregory M. Orlowski, Shruti Sharma, Francis Ka-Ming Chan, Stephanie A. Robertson, Kenneth L. Rock
Sterile particles cause several chronic, inflammatory diseases, characterized by repeating cycles of particle phagocytosis and inflammatory cell death. Recent studies have proposed that these processes are driven by the NLRP3 inflammasome, a platform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b62101e49c6e140683f17a2bb254df
https://europepmc.org/articles/PMC6608057/
https://europepmc.org/articles/PMC6608057/
Publikováno v:
ACS Chemical Biology
Proteases constitute a major class of drug targets. Endosomal compartments harbor several protease families whose attenuation may be beneficial to a number of biological processes, including inflammation, cancer metastasis, antigen presentation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6307abeb10e13edd336caaee084ba041
https://doi.org/10.1021/cb200292c
https://doi.org/10.1021/cb200292c
Publikováno v:
Traffic (Copenhagen, Denmark)
Cystatin F is a cysteine protease inhibitor that is selectively expressed in immune cells and unlike other cystatin family members is targeted to a significant extent to intracellular compartments. Initially made as an inactive glycosylated disulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f946c48b72786f5f863254c99c14519
http://europepmc.org/articles/PMC2691902
http://europepmc.org/articles/PMC2691902