Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Jeff Coller"'
Autor:
Ashley M. Curran, Alexander A. Girgis, Yura Jang, Jonathan D. Crawford, Mekha A. Thomas, Ryan Kawalerski, Jeff Coller, Clifton O. Bingham, Chan Hyun Na, Erika Darrah
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Antibodies directed against citrullinated proteins are commonly found in patients with rheumatoid arthritis. Here, the authors show that citrullination alters the peptide repertoire presented to T cells by altering protease cleavage and inducing prot
Externí odkaz:
https://doaj.org/article/167ebce599e34f1fa373394b0186f854
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Mutations in tRNA processing factors can lead to myelin disorders. This study shows that differentiated oligodendrocytes, cells that make the myelin, are characterized by different tRNA modifications and mRNA decay compared to their precursor cells.
Externí odkaz:
https://doaj.org/article/e3f53db27d6b4c708b911c9c925e4f44
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The relative abundance of specific tRNA can impact protein production rate, folding, and messenger RNA stability. Here the authors describe QuantM-tRNA seq — a method to monitor tRNA abundance and sequence variants — and uncover distinctions in i
Externí odkaz:
https://doaj.org/article/ef707c41b35c4390a78986746ab795bd
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228730 (2020)
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in the cell and is a major control point for modulating gene expression. In yeast and other model organisms, codon identity is a powerful determinant of transcript
Externí odkaz:
https://doaj.org/article/9b0d297e33144ab3b3aae497350dd684
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1704-1712 (2018)
Summary: Tissue-specific mRNA stability is important for cell fate and physiology, but the mechanisms involved are not fully understood. We found that zygotic mRNA stability in Drosophila correlates with codon content: optimal codons are enriched in
Externí odkaz:
https://doaj.org/article/d329f5098bbd4e6a86dd22b54798e8e6
Autor:
Haneui Bae, Jeff Coller
Publikováno v:
Mol Cell
Messenger RNA (mRNA) translation by the ribosome represents the final step on a complicated molecular dance from DNA to protein. Though classically considered a decipherer that translates our 64-word genetic code into a proteome of astonishing comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f64a062bbb415aae0a4b8c37c6f6c18
https://doi.org/10.1016/j.molcel.2022.03.032
https://doi.org/10.1016/j.molcel.2022.03.032
Autor:
Lilei Zhang, Domenick A. Prosdocimo, Xiaodong Bai, Chen Fu, Rongli Zhang, Frank Campbell, Xudong Liao, Jeff Coller, Mukesh K. Jain
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2368-2375 (2015)
Circadian rhythms offer temporal control of anticipatory physiologic adaptations in animals. In the mammalian cardiovascular system, the importance of these rhythms is underscored by increased cardiovascular disease in shift workers, findings recapit
Externí odkaz:
https://doaj.org/article/9e5d7f64870c429b888323f3b449c6a0
Autor:
Jenna E. Smith, Juan R. Alvarez-Dominguez, Nicholas Kline, Nathan J. Huynh, Sarah Geisler, Wenqian Hu, Jeff Coller, Kristian E. Baker
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1858-1866 (2014)
High-throughput gene expression analysis has revealed a plethora of previously undetected transcripts in eukaryotic cells. In this study, we investigate >1,100 unannotated transcripts in yeast predicted to lack protein-coding capacity. We show that a
Externí odkaz:
https://doaj.org/article/7aa099a3fc3b41aabeb2f83b1e44b314
Publikováno v:
eLife, Vol 5 (2016)
MicroRNAs are small (22 nucleotide) regulatory molecules that play important roles in a wide variety of biological processes. These RNAs, which bind to targeted mRNAs via limited base pairing interactions, act to reduce protein production from those
Externí odkaz:
https://doaj.org/article/ef7c047bdb2c4a98b402539d5585f6ff
Publikováno v:
Nature communications. 13(1)
Oligodendrocytes are specialized cells that confer neuronal myelination in the central nervous system. Leukodystrophies associated with oligodendrocyte deficits and hypomyelination are known to result when a number of tRNA metabolism genes are mutate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b9a3b677c4b16e1a223213ce69f0ba
https://pubmed.ncbi.nlm.nih.gov/36008413
https://pubmed.ncbi.nlm.nih.gov/36008413