Evaluating a Modified High Purity Polysorbate 20 Designed to Reduce the Risk of Free Fatty Acid Particle Formation

Autor: Steve Russell, Wenqiang Liu, Aadithya Kannan, Tamanna Shobha, Kyle Ritchie, Anthony Tomlinson, Miguel Saggu, Stephen Rumbelow, Jamie Giddings, Rosalynn Taing, Kathrin Gregoritza, Nidhi Doshi, Sandeep Yadav, Victor Nicoulin, Jeff Chu, Si Kai Cai, Lin Luis

Publikováno v: Pharmaceutical research. 38(9)

To evaluate a modified high purity polysorbate 20 (RO HP PS20)—with lower levels of stearate, palmitate and myristate esters than the non-modified HP PS20—as a surfactant in biopharmaceutical drug products (DP). RO HP PS20 was designed to provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a21df0590584752abfffc3de701c783
https://pubmed.ncbi.nlm.nih.gov/34495486

A Comprehensive Assessment of All-Oleate Polysorbate 80: Free Fatty Acid Particle Formation, Interfacial Protection and Oxidative Degradation

Autor: Aadithya Kannan, Ian C. Shieh, Alavattam Sreedhara, Tobias Graf, Arthur Wu, Kyle Ritchie, Mark Hu, Rosalynn Taing, Wayman Chan, Nidhi Doshi, Lin Luis, Pervina Kei, Wenqiang Liu, Jeff Chu, Jamie Giddings

Publikováno v: Pharmaceutical research. 38(3)

Enzymatic polysorbate (PS) degradation and resulting free fatty acid (FFA) particles are detrimental to biopharmaceutical drug product (DP) stability. Different types and grades of polysorbate have varying propensity to form FFA particles. This work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4df16a66086fa1c438897714437e30
https://pubmed.ncbi.nlm.nih.gov/33713012

Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adultC. elegansmuscle

Autor: Ann M. Rose, Dumitru Constantin-Teodosiu, David L. Baillie, Paul L. Greenhaff, Christopher J. Gaffney, Freya Shephard, Nathaniel J. Szewczyk, Jeff Chu

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle. 7:181-192

Background Declines in skeletal muscle structure and function are found in various clinical populations, but the intramuscular proteolytic pathways that govern declines in these individuals remain relatively poorly understood. The nematode Caenorhabd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e092d94be33924981f7b40c983a7c7c
https://doi.org/10.1002/jcsm.12040

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Autor: Jeff Chu, Kirsten N. Kangelaris, Michael A. Matthay, John C. Stein, Carolyn S. Calfee, Erika M. Moseson, Hanjing Zhuo, Kathleen D. Liu

Publikováno v: Critical Care Medicine. 40:1-328

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b2da8d68961e0db6d1e79163aba743b
https://doi.org/10.1097/01.ccm.0000424897.18413.d3

Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study

Autor: Carolyn S. Calfee, Michael A. Matthay, John C. Stein, Hanjing Zhuo, Kirsten N. Kangelaris, Jeff Chu, Erika M. Moseson, Kathleen D. Liu

Publikováno v: Journal of Intensive Care
Moseson, EM; Zhuo, H; Chu, J; Stein, JC; Matthay, MA; Kangelaris, KN; et al.(2014). Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.. Journal of intensive care, 2, 40. doi: 10.1186/2052-0492-2-40. UCSF: Retrieved from: http://www.escholarship.org/uc/item/7bs9b0vv
Journal of intensive care, vol 2, iss 1

Background Multiple scoring systems have been developed for both the intensive care unit (ICU) and the emergency department (ED) to risk stratify patients and predict mortality. However, it remains unclear whether the additional data needed to comput

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc4855811cf9c358416486cbf08779e
https://pubmed.ncbi.nlm.nih.gov/25960880