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Autor:
Michael O. Alberti, Brian S. White, Sang-hyun Kim, Ryan M. Nunley, Jin Shao, Cara Lunn Shirai, Lynn S. White, Monique Chavez, Jeff Bednarski, Sridhar Nonavinkere Srivatsan, John R. Pehrson, Tanzir Ahmed, Matthew J. Walter
Publikováno v:
Cell reports
SUMMARY Somatic mutations in spliceosome genes are found in ~50% of patients with myelodysplastic syndromes (MDS), a myeloid malignancy associated with low blood counts. Expression of the mutant splicing factor U2AF1(S34F) alters hematopoiesis and mR