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pro vyhledávání: '"Jeff Bagdanoff"'
Autor:
Chen Liu, Patrick James Sarver, Troy Smith, Huaixiang Hao, Ho Man Chan, Ying-Nan Chen, Robert Koenig, Brant Firestone, Murphy Hentemann, Martin Sendzik, Mitsunori Kato, Hongyun Wang, Eric McNeill, Ping Wang, Jorge Garcia-Fortanet, Jeff Bagdanoff, Zhouliang Chen, Gang Liu, Movarid Mohseni, Michelle Fodor, Mike Acker, Travis Stams, Bing Yu, Chris Towler, Shumei Liu, Michael Dore, Stan Spence, Laura R. La Bonte, Sarah Williams, Matthew J. LaMarche, Rukundo Ntaganda
Publikováno v:
Cancer Research. 79:LB-005
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator due to its role in the programmed cell death PD-L1/PD-1 pathway. Small molecule inhibition of SHP2 has been widely investigated includi